Infection Immunology and Translational Medicine
|Professor Keith Gull|
|Professor Fiona Powrie|
Structure of the Infection, Immunology and Translational Medicine programme
The course is integrated around three themes: Immunology; Infection; and Translational Medicine. In the first year, students undertake three short research projects and a series of seminars within each theme, tailored to their interests and background. Students can then make an informed choice about their main thesis research project, which starts at the beginning of the second year.
The first year of the IITM Programme would typically include:
- Three 10 week 'rotation' projects
- A short dissertation
- Taught courses, in the form of lectures and seminars
- Problem based learning sessions
- Further training and other events organised through the Medical Sciences Doctoral Training Centre
Students have the opportunity to work in a laboratory abroad, with supervisors from the Tropical Medicine unit of the Nuffield Department of Clinical Medicine who are associated with this programme.
Background to the research field
Infectious and non-communicable diseases including chronic inflammatory disease and cancer represent significant global health problems. Basic research in infection and immunity has brought important advances in the understanding of the molecular and cellular control of the immune response and the pathogenesis of disease. The key challenge is to translate this information into the clinic in the form of improved diagnosis and treatments for immune mediated diseases.
This programme provides opportunities for research in the basic biomedical science of infectious diseases caused by bacteria, viruses and parasites plus the innate and acquired immune system, together with the development and use of therapeutic drugs and vaccines. Students' personal basic science research will be deeply influenced by the clinical context. The programme is run from the Sir William Dunn School of Pathology but involves Departments and Institutes across the Medical Sciences Division and overseas, providing interdisciplinary training and fostering communication between researchers engaged in basic and more applied research.
The following supervisors are affiliated to this programme. Supervisors are linked to one of the three programme themes: Infection, Immunology or Translational Medicine. Students will undertake a short 'rotation' project in each of the three themes in their first year.
The biochemical basis of signal initiation and propogation, its fine tuning and stabilization that imparts during phenotypic changes.
Immunobiology of dendritic cells
Immunity to and pathogenesis of Malaria
Vaccination, cancer immunology and NKT cell function
Autoimmunity and Immune Regulation Group
T-cell Biology Group
Mahidol-Oxford Tropical Medicine Research Unit
The immunological synapse and integrating this into the 3D tissue context
Influenza virus replication at the molecular level.
Cell biology of Leishmania; role of the flagellum in host-parasite interactions
Paediatric HIV T cell immunology
Structural cell biology of virus infection
Aspects of the pathogenicity of African trypanosomes and inherited ciliary diseases of humans.
Jenner Institute / Infectious Diseases / Malaria Vaccine Trials
Genetics of nematode immunity and development
HIV-Macrophage interactions and stem cell technology
Receptor Structure Research Group
Functional genomics of inflammation and immunity
Genomics and Global Health
Host-pathogen interactions including the Complement system, bacterial adhesion, type III and tat secretion systems and picornaviral-receptor interactions.
Drosophila as a model to study innate immunity
The interaction of molecular epidemiology, population biology and public health for bacterial pathogens
Host-pathogen interactions in the intestine and their impact on intestinal inflammation
KEMRI Wellcome Collaborative Research programme
Cellular Immunology and Vaccine Development
Cutaneous Immunology, Allergy, Dermatology, Viral infections and the skin, Innate and adaptive immune responses, Role of epithelium in immunity.
Antiviral Immunity, HIV
Adult and Paediatric Vaccinology and Paediatric Infection and Immunity
Innate and adaptive immune pathways that control intestinal homeostasis and their breakdown in inflammatory bowel disease.
Nucleic Acid Sensing by Innate Immune Receptors
Immunity to HIV infection
Innate immunity in infectious and inflammatory disease
Pathogenesis and Prevention of Bacterial Meningitis
Molecular analysis of T and NK cell recognition.
Regulatory T-cells, nutrient sensing, mTOR, proteomics of regulatory T-cells
Tropical Medicine, Infectious Disease and Drug Discovery
Transplant rejection and tolerance
Hepatitis - Development of Antiviral Strategies
- It is possible to apply from 1 September 2013 for entry to the Infection Immunology and Translational Medicine DPhil programme in October 2014.
- The application deadline is 10 January 2014.
- Applications will be considered by a short-listing panel and applicants will be notified of the outcome by email, as soon as possible after the deadline.
- Short-listed candidates will be invited to interview. Interviews are expected to be held on 23 and 24 January 2014.
- Home/EU & Overseas candidates are eligible to apply
- Please see the University application guide for details of required qualifications.
How to apply
- Applications for the Programmes must be received by 10 January 2014. Please refer to the University application guide. Applications should be made using the online application form.
- If candidates are unable to submit an online application they should contact us well before the deadline, by email to firstname.lastname@example.org.
When completing the application form, please note the following:
1. Programme of Study
- 003920 – D.Phil. in Infection, Immunology and Translational Medicine
2. Proposed field, title of research project and supervisor details.
There is no need to enter a proposed field or research project title, or to identify supervisors. Please enter the name of the doctoral programme to which you are applying. You will not be required to submit a research project proposal.
3. College choice
Candidates are encouraged to identify a college when applying, rather than using the Open College option.
It is suggested that applicants to the Infection, Immunology and Translational Medicine programme select St Edmund Hall as their college choice.
Please click here for information on which colleges accept applicants to this programme.
4. Department or Faculty
Please enter ‘Medical Sciences Doctoral Training Centre’
5. Language Skills
Please review the English language requirements for applicants whose first language is not English. This programme requires applicants to meet the higher level scores.
6. Proposed Funding Arrangements:
Please enter 'Wellcome Trust' as the Funding Source, ‘£40,000' (as an approximate figure) for the Amount of Funding per year, '4 years' as Period Covered and 'Applied to' for Funding Status. Please leave the Departmental Studentship Applications section blank.
The Wellcome Trust studentships include:
- College fees and University fees at the Home/EU rate
- a stipend for the four years of study
- travel and training allowances
Overseas applicants who apply by the deadline of 10 January 2014 and who are successful in their application will be nominated for additional funding from within the University, to cover the overseas fee rate.
7. Supporting Materials
a personal statement
transcripts for your University level education
There is no need to write a research proposal - please submit a personal statement instead. Your personal statement should be a maximum of one page and should focus on your interest in, and experience of this research field rather than personal achievements, interests or aspirations.
You are advised to keep the size of uploaded documents (e.g. CV, transcripts) to a minimum, for administrative purposes.
If shortlisted, candidates will be interviewed in Oxford. Candidates from outside Europe are normally interviewed by phone unless they are in Europe at the time of interview.