Her research focuses on understanding early infection events that define the cellular and tissue tropism of clinically important human viruses. Jane’s work has identified pathways that define hepatitis C virus entry into hepatocytes and routes of dissemination in the liver.
Our current focus is on hepatitis B and C viruses (HBV/HCV), the leading drivers for hepatocellular carcinoma, and includes studies on: (1) the role of hypoxia in HIV/HCV or HBV co-infection; (2) the molecular pathways defining HBV transmission and impact on innate immune responses; (3) circadian clock control of HBV and HCV replication and (4) bio-active lysophosphatidic acid lipid signalling in viral replication and associated hepatocellular carcinogenesis.
Her current work seeks to translate findings from in vitro model systems to understand viral-associated pathology and hepatocellular carcinoma in order to design improved anti-viral therapies.
Jane holds a Hans Fischer Senior Fellowship and visiting Professorship at Technical University Munich and was awarded the Founders Award for Research Excellence at University of Birmingham in 2015.
Microbiology, Infection and Tropical Medicine