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News

A close up of gloved medical hands holding a vaccination needle and pressing a cotton pad against an elderly woman's arm.

New shingles vaccine linked to lower risk of coronary heart disease, stroke and heart failure – major study indicates

The shingles vaccine currently in use, called ‘Shingrix’, is associated with a reduced risk of cardiovascular events – including heart attacks, heart failure and stroke – compared to the previous shingles vaccine, according to a major new study published in Nature Medicine.

Photo of a person holding a vape

Vapes help more people quit smoking than other methods, Oxford-led Cochrane review finds

An updated Cochrane review led by Oxford researchers finds nicotine e-cigarettes help more people quit smoking than nicotine patches and gum, behavioural support or no support. The living review now includes 80 trials and nearly 30,000 participants.

Brain imaging to identify the brain circuits

Brain imaging study reveals how we decide whether we are in control

A brain imaging and stimulation study led by the University of Oxford has identified the brain mechanisms that help us work out whether the consequences we experience are caused by our own actions or by circumstances beyond our control.

A close up of semaglutide injections

Semaglutide associated with fewer cognitive problems in people with mental illness

Semaglutide, widely used to treat diabetes and obesity, was associated with fewer cognitive signs and symptoms in people with psychiatric disorders, according to a new study led by researchers at the University of Oxford.

Matt Costa and Rachel Kuo

Oxford researchers win prestigious national leadership prizes

Professor of Orthopaedic Trauma Matthew Costa and NIHR Doctoral Research Fellow Rachel Kuo, both from the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, were announced among the winners of the NIHR20 Research Leaders Prizes in recognition of their outstanding contributions to health and care research.

Degradation of NUDT5 (Artistic representation)

A new layer of control for a decades-old leukemia drug

How cells respond to the leukemia drug 6-thioguanine still holds surprises: A new study, led jointly by researchers from the Research Center for Molecular Medicine of the Austrian Academy of Sciences (CeMM) and the University of Oxford identifies NUDT5 as an unexpected regulator of drug sensitivity and reveals that its role has nothing to do with its enzymatic activity.

A group of young children watches unrecognizable yoga teacher to learn how to breathe properly.

Study of 3,400 children links London's Ultra Low Emission Zone with improved lung growth

The proportion of London children with clinically impaired lung function fell from around one in seven to one in 11 over five years following the introduction of London’s Ultra Low Emission Zone (ULEZ), according to a major five-year study jointly led by researchers from the Nuffield Department of Primary Care Health Sciences, University of Oxford.

Two male scientists working, with one of them pointing at a screen.

New open-source tool helps researchers test robustness of findings

Oxford researchers launch RobustiPy, a new open-source tool designed to ensure research is robust and reliable.

Fingers pointing towards each other as in the Creation of Adam.

Arthritis origins may begin before birth, study finds

Researchers at the Kennedy Institute (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) have discovered that some joints may be more susceptible to inflammatory arthritis before birth, offering new insight into why rheumatoid arthritis attacks particular joints while sparing others.

Health care professional

100th patient enrolled in PARTNERS trial to identify the first effective treatments for Bundibugyo ebolavirus disease

This milestone, reached just 12 weeks after the announcement of the outbreak, makes PARTNERS the fastest-ever randomised controlled trial of treatments for Ebola.

A nurse measures an older man's blood pressure during a healthcare appointment.

Statins reduce hospital admissions but increase overall healthcare use

Study finds statins reduce healthcare use initially, but longer lives mean greater overall demand for health services over time

A person's hands can be seen typing on a keyboard with an AI chatbot screen superimposed over the top

New audit system maps how mental health risks emerge in AI chatbot conversations

Scientists have developed a framework for stress-testing how AI chatbots respond to vulnerable users, helping researchers identify weaknesses and test ways of making mental-health interactions safer.

A person serving a bowl of salad

Expert Comment: Climate-friendly food procurement and advertising: what are local authorities in England doing?

Professor Mike Rayner (Nuffield Department of Population Health), Dr Jessica Renzella (Nuffield Department of Primary Care Health Sciences) and Dr Hannah Forde (Nuffield Department of Primary Care Health Sciences) argue that local authorities could play a significant role in steering UK diets to become healthier and more sustainable.

Dopaminergic neurons with tiny aggregates

Oxford researchers uncover how Parkinson's disease protein damages brain cells

A new study reveals a key mechanism by which the protein alpha-synuclein, the hallmark of Parkinson's disease, damages neurons (brain cells) by blocking a vital cellular gateway. The results of the study, published in Nature Communications, help to explain how the disease begins and highlights a potential new target for treatment.

Smoking prohibited sign

Combination of tobacco control policies needed to further reduce smoking deaths

Studies have shown that long‑term quitters who haven’t smoked for 10 years or more get back almost all of the lost life. Saving more lives needs combined measures.

World map

The Global Health Network joins the Nuffield Department of Primary Care Health Sciences

The Global Health Network, a WHO Collaborating Centre with more than one million members worldwide, has joined the Nuffield Department of Primary Care Health Sciences, strengthening the department's work to advance global primary health care.

A healthcare professional uses a stethoscope to examine an older woman during a consultation in a clinical setting.

New study highlights importance of heart disease treatments targeting both cholesterol and inflammation

The study identifies 12 proteins that could lead to new heart disease treatments targeting both cholesterol and inflammation.

Tommys 10 year anniversary event

Tommy’s National Centre for Miscarriage Research celebrates ten years of progress

Tommy's National Centre for Miscarriage Research marks ten years of pioneering research, with the Nuffield Department of Women's & Reproductive Health now leading the next phase of its work to improve miscarriage care and prevention.

Psoriatic arthritis in elbow

Trial exploring effects of drug on liver in psoriasis patients recruits first UK patient

The first patient in the UK has been recruited to a clinical trial investigating how a new drug affects liver inflammation and scarring in people with psoriatic disease using a new non-invasive MRI scanning technique.

Vaccine glass vial

First volunteer vaccinated in the world's first Bundibugyo ebolavirus vaccine trial

The University of Oxford’s Oxford Vaccine Group has today successfully vaccinated the first volunteer in the world’s first clinical trial of a vaccine designed to protect against Bundibugyo ebolavirus (BDBV).

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