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David Greaves

Inflammation biology – identifying novel pathways that reduce macrophage activation in chronic inflammation

Work in my laboratory at the Dunn School of Pathology in Oxford aims to understand the role of macrophages and chemokines in acute and chronic inflammation including the development of atherosclerotic lesions. We are also interested in the role monocyte recruitment and macrophage differentiation play in tissue repair following myocardial infarction.

My laboratory has developed methods to follow monocyte / macrophage chemotaxis in vitro using real-time methodologies (Iqbal AJ et al. PLoS One. 2013; 8:e58744; Taylor L et al. Sci Rep. 2015; 5:10682) and in vivo using hCD68-Gfp transgenic reporter mice (Iqbal AJ, McNeill E et al. Blood. 2014; 124: e33-44).

Recently we developed a novel live cell imaging platform to quantify macrophage phagocytosis of opsonised and unopsonised microbial bioparticles (Kapellos T et al. Biochemical Pharmacology. 2016;  in press).

Working with Prof Keith Channon we have optimized hydrodynamic gene delivery methods to study the effect of CC chemokine binding proteins in pre-clinical models of vascular inflammation (McNeill E et al Sci Rep. 2015; 5:17404).