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Jan Rehwinkel


Nucleic acid sensing by innate immune receptors

Current Position:

Since 2012  Associate Professor of Innate Immunology

Group leader, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK

Research Experience:

2007-2012   

Postdoctoral Research Fellow with Dr Caetano Reis         e Sousa, Immunobiology Laboratory, Cancer Research UK, London Research Institute, London, UK 

2003-2007   

Doctoral Training with Dr Elisa Izaurralde, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany

Qualifications:

2007 PhD, European Molecular Biology Laboratory (EMBL)  Heidelberg, Germany

2003 Diploma in Biology, Ruprecht-Karls University, Heidelberg, Germany (equivalent to MSc degree)

                                  

Selected Publications:  

Maelfait J, Bridgeman A, Benlahrech A, Cursi C, Rehwinkel J. Restriction by SAMHD1 limits cGAS/STING-dependent innate and adaptive immune responses to HIV-1. Cell Reports. 2016; 6:1492–1501 

Bridgeman A, Maelfait J, Davenne T, Partridge T, Peng Y, Mayer A, Dong T, Kaever V, Borrow P, Rehwinkel J. Viruses transfer the antiviral second messenger cGAMP between cells. Science. 2015; 349:1228-1232

Rehwinkel J1, Maelfait J, Bridgeman A, Rigby R, Hayward B, Liberatore RA, Bieniasz PD, Towers GJ, Moita LF, Crow YJ, Bonthron DT, and Reis e Sousa C1. SAMHD1-dependent retroviral control and escape in mice. The EMBO Journal. 2013; 32:2454-2462

1 corresponding authors

Rehwinkel J1, Tan CP1, Goubau D, Schulz O, Pichlmair A, Bier K, Robb N, Vreede F, Barclay W, Fodor E, Reis e Sousa C. RIG-I detects viral genomic RNA during negative-strand RNA virus infection. Cell. 2010; 140:397-408.

1 with equal contribution

Eulalio A1, Rehwinkel J1, Stricker M, Huntzinger E, Yang SF, Doerks T, Dorner S, Bork P, Boutros M, Izaurralde E. Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev. 2007; 21:2558-2570.

1 with equal contribution