MRCPCH FRCPath PhD
Associate Professor of Paediatric Haematology
- Wellcome Trust Clinical Research Career Development Fellow
- Honorary Clinical Lecturer in Paediatric Haematology, Great Ormond Street Hospital, London
Main research interest: understanding the origins and biology of childhood leukaemia.
The main focus of my research is to study prenatal B lymphopoiesis in order to understand the origins of childhood leukaemia, in particular infant acute lymphoblastic leukaemia (ALL). Prenatal B lymphopoiesis is different from adult B cell development; and developmentally-regulated characteristics of fetal B-progenitors are likely to provide the 'oncogenic' cellular context necessary to co-operate with MLL rearrangements to induce infant ALL. We have recently defined the B lymphoid developmental hierarchy before birth, and my research aims to identify the target cell population for leukaemia initiation in infant ALL. Characterisation of the target cell by molecular and functional assays, including developmental differences when compared to postnatal cells, will allow us to identify specific pathways that can be targeted for future therapies. I am also a member of Prof Irene Roberts’ team investigating how trisomy 21 perturbs haematopoiesis before birth and its implications for Down syndrome associated leukaemias in children.
Previous academic placements: LLR Clinical Training Fellowship (2007-2011) and NIHR Academic Clinical Lectureship in Paediatric Haematology (2011-2015) at Imperial College London. During my placement at Imperial College, I worked primarily on characterising fetal haematopoiesis and understanding how it is perturbed by trisomy 21. Bloodwise Clinician Scientist (2015-2020) at University of Oxford.