Bloodwise Clinician Scientist in Paediatric Haematology
- Honorary Clinical Lecturer in Paediatric Haematology, Great Ormond Street Hospital, London
Main research interest: understanding the origins and biology of childhood leukaemia.
I initially followed a career pathway in paediatrics with a special interest in paediatric haemato-oncology. My original research at Imperial College London involved the characterisation of trisomy 21 associated perturbation of human fetal haematopoiesis (LLR Clinical Training Fellowship 2007-2011). This PhD project gave rise to several exciting questions regarding the origins and biology of childhood leukaemia and I subsequently worked further on understanding the ontogeny of human fetal B lymphoid development as an NIHR funded Academic Clinical Lecturer in Paediatric Haematology (2011-2015) at Imperial College, London. The results of this research point to a link between fetal lymphopoiesis and infant ALL that may be key to understanding the origins of this biologically unique leukaemia.
Current research: I am currently funded by Bloodwise as a Clinician Scientist in Paediatric Haematology and the main focus of my research is to study human fetal B lymphopoiesis in order to elucidate the origins of childhood leukaemia, in particular infant ALL. More specifically, my research aims to identify and characterise the target fetal cell population for leukaemia initiation in infant ALL. I am also a member of Prof Irene Roberts’ team trying to understand how trisomy 21 perturbs fetal haematopoiesis and its implications for Down syndrome associated and other leukaemias in children.