Scientist working in Oxford have made major contributions to this field. Robert Gwynne Macfarlane was instrumental in identifying the clotting cascade. George Brownlee first cloned the Factor IX gene, leading to the production of recombinant Factor IX now used to treat patients with haemophilia B. Sir David Weatherall pioneered research into the inherited basis of blood disorders, particularly thalassaemia, culminated in a prestigious Lasker Award in 2010.
Research in haematology is concentrated in the MRC Molecular Haematology Unit housed in the Weatherall Institute of Molecular Medicine and the Nuffield Department of Clinical Laboratory Sciences. Areas of strength include the mechanisms regulating globin gene expression, leukemia and lymphomas.