LOCATION
Botnar Research Centre, Old Road, Headington, Oxford OX3 7LD
Colleges
Claire Edwards
Professor of Bone Oncology
- Director of Graduate Studies for NDS
Professor Claire Edwards (née Shipman) obtained a first class honours degree and Ph.D. from the University of Sheffield, where she began her career in cancer-induced bone disease.
Following postdoctoral studies at the University of Sheffield and the University of Oxford, Professor Edwards moved to the United States in 2004 to take up assistant professor positions at the University of Texas Health Science Center at San Antonio and subsequently at Vanderbilt University.
Professor Edwards is the recipient of multiple awards and fellowships, including most recently, the Iain T. Boyle Award from the European Calcified Tissue Society.
Professor Edwards relocated her lab to the University of Oxford in 2010 as a University Lecturer in Bone Oncology, with a joint appointment in the Nuffield Department of Surgical Sciences (NDS) and the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), and a fellowship at St. Edmund Hall.
Research interests are focused upon the pathogenesis of cancer-induced bone disease, including the contributions of the host bone marrow microenvironment and the role of obesity, adipocytes and adipokines.
Key publications
Metabolic profiling of prostate cancer in skeletal microenvironments identifies G6PD as a key mediator of growth and survival
Journal article
Whitburn J. et al, (2022), Science Advances, 8
Myeloma Cells Down-Regulate Adiponectin in Bone Marrow Adipocytes Via TNF-Alpha
Journal article
Morris EV. et al, (2020), Journal of Bone and Mineral Research, 35, 942 - 955
Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease
Journal article
Gooding S. et al, (2019), Nature Communications, 10
Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer
Journal article
Rao SR. et al, (2017), British Journal of Cancer, 116, 227 - 236
Diet-induced obesity promotes a myeloma-like condition in vivo
Journal article
Lwin ST. et al, (2015), Leukemia, 29, 507 - 510
Recent publications
Metabolism in Tumour-Induced Bone Disease
Journal article
Ormsby RT. and Edwards CM., (2026), Current Osteoporosis Reports, 24
High-cholesterol diet fuels myeloma progression, dysregulates adipokine expression in vivo, and impairs treatment response ex vivo.
Journal article
Gámez B. et al, (2026), Haematologica
Circulating tumour cells as a window into lethality in prostate cancer
Journal article
Abusamra SM. et al, (2026), Nature Reviews Urology
Biochemical bone biomarkers in plasma cell dyscrasias for the British Journal of Haematology
Journal article
Nador G. et al, (2026), British Journal of Haematology
Medical Students’ Observations of High Value and Potentially Wasteful Care Behaviors Modeled During Clinical Rotations
Journal article
Wade A. et al, (2025), Journal of General Internal Medicine
