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NNRCO will be composed of multiple research departments, as well as a strategic and business operations department, led by Suzie Markin. As of February 2018 NNRCO has several research departments established.

 

Department of Discovery Bioinformatics  

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Led by Dr. Jan Nygaard Jensen, this department aims to go beyond data analysis services to direct and drive Type 2 diabetes target discovery using multiple bioinformatics approaches. The goal is to closely link wet lab experimental findings to provide a feedback loop of result prioritization and hypothesis generation. Our bioinformatic work will be anchored in strong biology, target networks and the druggable genome.

 

 

The Department of Advanced Genomics

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Led by Dr. Quin Wills, this department aims to discover and validate modifiers of nutrient flux, with a focus on the relationship between fatty liver disease and insulin resistance. They do this using cellular genomics methods such as single-cell sequencing and CRISPR, both for screening and building spatiotemporal models of liver function at a cellular resolution.

 

 

 

THE DEPARTMENT OF STEM CELL ENGINEERING

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Led by Dr. Nicola Beer, this department aims to discover novel secreted factors and corresponding signalling pathways which modify beta-cell function, health, and viability. It combines in vitro-differentiated human stem cell-derived models with CRISPR and other genomic targeting techniques to assay beta-cell function from a single gene up to a genome-wide scale. Understanding the genes and pathways underlying beta-cell function (and dysfunction) highlights potential targets for new Type 2 Diabetes therapeutics. 

 

 THE DEPARTMENT OF HIGH-THROUGHPUT IMAGING

Led by Dr. Jan Nygaard Jensen, this department seeks to identify novel secreted proteins and peptides that modulate anti-diabetic in vitro based assays using robotic live-cell microscopy and other high-throughput cell physiology approaches. 

 

Page updated 15/02/2018