Websites

British Heart Foundation
Funding body
Oxford Heart Vessels and Fat (ox-HVF) cohort
Prospective translational programme
Cardiovascular Research
Journal
Reuters video on FAI technology
Press
British Atherosclerosis Society
National Society
The Lancet 2024
Video

Charalambos Antoniades

British Heart Foundation Chair of Cardiovascular Medicine

Director, Acute Multidisciplinary Imaging and Interventional Centre (AMIIC)
Deputy Head, Division of Cardiovascular Medicine
Professor of Cardiovascular Medicine
Honorary Consultant Cardiologist
Chair of the British Atherosclerosis Society

Crosstalk between adipose tissue and the cardiovascular system: From target discovery to advanced imaging and risk prediction

Adipose tissue is now considered to be a “biochemical factory” in the human body, producing a wide range of bioactive molecules, such as adipokines. These molecules exert local autocrine effects, but they also have paracrine and endocrine properties, and may play a critical role in the regulation of redox state and signalling in various tissues, such as the vascular wall and myocardium. Our group studies the mechanisms by which different adipose tissue depots in the human body affect vascular and myocardial redox state in atherosclerosis. We also search for novel therapeutic strategies targeting vascular and myocardial redox signalling directly or through changes in the crosstalk between adipose tissue and cardiovascular system.

Our group undertakes translational research, moving from bench to bedside and vice versa. We use various clinical research tools, such as non-invasive imaging and others, for the evaluation of vascular / myocardial function. This includes studies on human tissues; we have developed a number of ex vivo models of human tissue (vessels, myocardium and adipose tissue) for translational research, which are complemented by tissue and cell culture techniques. We have also established a large bioresource of human vascular, myocardial and adipose tissue in collaboration with other academic institutions across the world (The Oxford Heart Vessels & Fat (ox-HVF) cohort) and this is currently being used to support hypothesis driven research in the field of vascular and myocardial redox state regulation.

In our lab state-of-the-art techniques are used to visualise and quantify vascular and myocardial free radical production.

Using genetic tools to identify patients with pre-specified genetic traits, enables us to apply a “recruit-by-genotype” approach to address biological questions related to the cross-talk between adipose tissue and vascular/myocardial redox signalling in human cardiovascular disease.

We are also using state-of-the-art non-invasive imaging techniques (advanced ultrasound and CT imaging techniques) to study the structure and function of the cardiovascular system and explore its interactions with the adipose tissue. This programme of work led to the recent discovery of the "inside-to-outside" signals from the human cardiovascular system to the adipose tissue, and allowed the development of new clinical applications of cardiovascular imaging.

Since 2015, the group runs the Oxford Cardiovascular Computed Tomography programme, in partnership with the Manor Hospital, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. The group is using artificial intellience and machine learning approaches to analyse radiotranscriptomic signatures that lead to the develpment of new imaging biomarkers. A recent example is that of the develpment of Fat Attenuation Index (FAI), a new biomarker that detects inflammation in the human coronary arteries by analysing the changes of weighed CT attenuation of perivascular adipose tissue (Science Transl Med 2017). FAI has striking predictive value for cardiac mortality and acute coronary events, as demonstrated in a large prospective clinical study (CRISP-CT) organised together with Erlangen University (Germany) and Cleveland Clinic (USA) (Lancet 2018).

Since 2015, the group runs the Oxford Academic cardiovascular Computed Tomography (OXACCT) programme, in partnership with the Manor Hospital, supporting the use of state-of-the-art cardiovascular CT imaging by groups within the University of Oxford. Within the group, we run the OXACCT Core Lab, peforming advanced analysis of cardiovascular CT images with specific focus on analysis of coronary plaques and perivascular adipose tissue.

Our group also organises small-scale randomised clinical trials that include extensive cardiovascular phenotyping, testing the effects of treatments (statins, folates etc) on the biology of the human vascular wall, myocardium and adipose tissue.

Key publications

Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study

Chan K. et al, (2024), Lancet, 403, 2606 - 2618

Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers

Antoniades C. et al, (2023), European Heart Journal, 44, 3827 - 3844

Role of Human Epicardial Adipose Tissue–Derived miR-92a-3p in Myocardial Redox State

Carena MC. et al, (2023), Journal of the American College of Cardiology, 82, 317 - 332

Using artificial intelligence to study atherosclerosis, predict risk and guide treatments in clinical practice

Antoniades C. et al, (2023), European Heart Journal, 44, 437 - 439

Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications

Akoumianakis I. et al, (2022), Nature Reviews Cardiology, 19, 783 - 797

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

Kotanidis CP. et al, (2022), The Lancet Digital Health, 4, e705 - e716

Effects of canagliflozin on human myocardial redox signalling: Clinical implications

Kondo H. et al, (2021), European Heart Journal, 42, 4947 - 4960

Standardized measurement of coronary inflammation using cardiovascular computed tomography: Integration in clinical care as a prognostic medical device

Oikonomou EK. et al, (2021), Cardiovascular Research, 117, 2677 - 2690

Fat-Secreted Ceramides Regulate Vascular Redox State and Influence Outcomes in Patients With Cardiovascular Disease

Akawi N. et al, (2021), Journal of the American College of Cardiology, 77, 2494 - 2513

Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease

Oikonomou EK. et al, (2020), Cardiovascular Research, 116, 2040 - 2054

Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study

Oikonomou EK. et al, (2020), Journal of the American College of Cardiology, 76, 755 - 757

Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

Meakin PJ. et al, (2020), Journal of Clinical Investigation, 140, 4104 - 4117

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition

Akoumianakis I. et al, (2020), Science Translational Medicine, 12

Imaging residual inflammatory cardiovascular risk

Antoniades C. et al, (2020), European Heart Journal, 41, 748 - 758

A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CTangiography

Oikonomou EK. et al, (2019), European Heart Journal, 40, 3529 - 3543

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

Akoumianakis I. et al, (2019), Science Translational Medicine, 11

Association of Biologic Therapy with Coronary Inflammation in Patients with Psoriasis as Assessed by Perivascular Fat Attenuation Index

Elnabawi YA. et al, (2019), JAMA Cardiology, 4, 885 - 891

Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data

Oikonomou EK. et al, (2018), The Lancet, 392, 929 - 939

Detecting human coronary inflammation by imaging perivascular fat

Antonopoulos AS. et al, (2017), Science Translational Medicine, 9

Mutual regulation of epicardial adipose tissue and myocardial redox state by PPAR-γ/adiponectin signalling

Antonopoulos AS. et al, (2016), Circulation Research, 118, 842 - 855

Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: The regulatory role of perivascular adipose tissue

Antonopoulos AS. et al, (2015), Diabetes, 64, 2207 - 2219

Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels

Margaritis M. et al, (2013), Circulation, 127, 2209 - 2221

Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery: Effects of short-term pre-operative statin treatment

Antoniades C. et al, (2012), Journal of the American College of Cardiology, 59, 60 - 70

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis

Antoniades C. et al, (2011), Circulation, 124, 1860 - 1870

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling

Antoniades C. et al, (2011), Circulation

Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity

Antoniades C. et al, (2010), Circulation, 122

The CD40/CD40 Ligand System. Linking Inflammation With Atherothrombosis

Antoniades C. et al, (2009), Journal of the American College of Cardiology, 54, 669 - 677

Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation

Antoniades C. et al, (2007), Circulation, 116, 2851 - 2859

Global improvement of vascular function and redox state with low-dose folic acid: Implications for folate therapy in patients with coronary artery disease

Shirodaria C. et al, (2007), Circulation, 115, 2262 - 2270

Genetic Polymorphisms of Platelet Glycoprotein Ia and the Risk for Premature Myocardial Infarction. Effects on the Release of sCD40L During the Acute Phase of Premature Myocardial Infarction

Antoniades C. et al, (2006), Journal of the American College of Cardiology, 47, 1959 - 1966

Recent publications

Coronary Inflammation Is Associated With Plaque Progression in Men With HIV.

Nasrallah N. et al, (2026), Circ Cardiovasc Imaging

Pathophysiology, prevention, and management of coronary microvascular obstruction: A clinical consensus statement of the ESC Working Group on Coronary Pathophysiology & Microcirculation, the ESC Working Group on Thrombosis, and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC

Cenko E. et al, (2026), European Heart Journal, 47, 4215 - 4241

Early Prediction of Heart Failure From Routine Cardiac CT Using Radiomic Phenotyping of Epicardial Fat

Oikonomou EK. et al, (2026), Journal of the American College of Cardiology, 87, 3539 - 3555

Sex and gender differences in coronary pathophysiology and ischaemic heart disease: A Scientific Statement of the ESC Working Group on Coronary Pathophysiology & Microcirculation, the Association for Acute CardioVascular Care, and the European Association of Percutaneous Cardiovascular Interventions of the ESC

Manfrini O. et al, (2026), European Heart Journal, 47, 2727 - 2749

Reimagining Thomas Lewis's perspective: using artificial intelligence tools to predict cardiovascular risk from computed tomography.

Kotronias RA. et al, (2026), Heart

Imaging and Quantification of Perivascular Adipose Tissue

Foran D. et al, (2026), Arteriosclerosis Thrombosis and Vascular Biology, 46

Anatomical, physiological and inflammatory characterization of nonculprit vessels in patients undergoing primary PCI for ST-elevation myocardial infarction in the presence of multivessel disease: Rationale and design of the PICNIC study

Mahmoudi M. et al, (2026), American Heart Journal, 292

A novel deep learning model for enhanced segmentation of internal mammary artery, aorta and their perivascular regions

Sobirov I. et al, (2026), European Heart Journal – Digital Health, 7

Fully automated plaque quantification with human-level performance and validation in large-scale cardiac CT cohort

Sobirov I. et al, (2026), European Heart Journal – Digital Health, 7

Lipoprotein(a) and Vascular Redox State in Patients With Advanced Coronary Atherosclerosis

Polkinghorne MD. et al, (2026), Arteriosclerosis Thrombosis and Vascular Biology, 46, 232 - 247

Non-invasive assessment of coronary inflammation improves the diagnostic accuracy of coronary death in post-mortem CT angiography

Xie C. et al, (2026), Journal of Cardiovascular Computed Tomography

Effectiveness of a novel intervention (Super Rehab) in overweight patients with atrial fibrillation (SuRe AF): protocol for a randomised controlled trial

Murphy D. et al, (2025), BMJ Open, 15

From lipids and inflammation to artificial intelligence-driven therapeutics: the 93rd European atherosclerosis society (EAS) congress 2025 in focus

Gurgone D. et al, (2025), Cardiovascular Research, 121, 1302 - 1305

Pericoronary Adipose Tissue Imaging and the Need for Standardized Measurement of Coronary Inflammation: Translating PCAT Attenuation Gradients Into FAI Score for Clinical Use

Antoniades C. and Chan K., (2025), Jacc Cardiovascular Imaging, 18, 895 - 898

Coronary inflammation and cardiovascular risk in breast cancer after radiotherapy

Kotanidis CP. et al, (2025), European Heart Journal, 46, 2924 - 2927

Scalable screening for structural heart disease: promises from artificial intelligence-electrocardiogram tools

Antoniades C. and Chan K., (2025), European Heart Journal Digital Health, 6, 521 - 523

Cost-effectiveness of a novel AI technology to quantify coronary inflammation and cardiovascular risk in patients undergoing routine coronary computed tomography angiography

Tsiachristas A. et al, (2025), European Heart Journal Quality of Care Clinical Outcomes, 11, 434 - 444

Benchmarking Photon-Counting Computed Tomography Angiography Against Invasive Assessment of Coronary Stenosis: Implications for Severely Calcified Coronaries

Kotronias RA. et al, (2025), Jacc Cardiovascular Imaging, 18, 572 - 585

Using artificial intelligence to spot heart failure from ECGs: is it prime time?

Antoniades C. and Chan K., (2025), European heart journal, 46, 1054 - 1056

Assessing the impact of COmorbidities and Sociodemographic factors on Multiorgan Injury following COVID-19: rationale and protocol design of COSMIC, a UK multicentre observational study of COVID-negative controls

Shergill S. et al, (2025), BMJ open, 15

Obesity and cardiovascular disease: an ESC clinical consensus statement

Koskinas KC. et al, (2025), European Journal of Preventive Cardiology, 32, 184 - 220

Expression of Concern: Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction (J Clin Invest (2020) 130:8 (4104–4117) DOI: 10.1172/JCI122237)

Meakin PJ. et al, (2025), Journal of Clinical Investigation, 135

Evaluating Acute Ischemic Myocardial Injury With Photon-Counting Computed Tomography

Kotronias RA. et al, (2025), Jacc Cardiovascular Imaging

Intra-operative and post-operative management of conduits for coronary artery bypass grafting: a clinical consensus statement of the European Society of Cardiology Working Group on Cardiovascular Surgery and the European Association for Cardio-Thoracic Surgery Coronary Task Force

Sandner S. et al, (2025), European Heart Journal, 46, 19 - 34

CT coronary angiography in the lipid clinic: a pilot study and lipidologist survey

Graby J. et al, (2025), International Journal of Cardiovascular Imaging

Using artificial intelligence to study atherosclerosis from computed tomography imaging: A state-of-the-art review of the current literature

Klüner LV. et al, (2024), Atherosclerosis, 398

Artificial intelligence in cardiovascular medicine: clinical applications

Lüscher TF. et al, (2024), European Heart Journal, 45, 4291 - 4304

Obesity and cardiovascular disease: an ESC clinical consensus statement

Koskinas KC. et al, (2024), European Heart Journal, 45, 4063 - 4098

Calcification vs Inflammation: The Modern Toolkit for Cardiovascular Risk Assessment

Antoniades C. and Chan K., (2024), JACC: Cardiovascular Imaging, 17, 1225 - 1228

Inflammatory risk and cardiovascular events in patients without obstructive coronary artery disease: the ORFAN multicentre, longitudinal cohort study

Chan K. et al, (2024), Lancet, 403, 2606 - 2618

Photon-counting computed tomography: ‘one-stop shop’ for coronary stenosis, inflammation, and myocardial assessment in ST-segment elevation acute coronary syndrome

Kotronias RA. et al, (2024), European Heart Journal Cardiovascular Imaging, 25

Artificial intelligence in cardiovascular imaging—principles, expectations, and limitations

Antoniades C. and Oikonomou EK., (2024), European Heart Journal, 45, 1322 - 1326

Seeing Is Believing: Photon Counting Computed Tomography Clearly Images Directional Deep Brain Stimulation Lead Segments and Markers After Implantation

Manfield J. et al, (2024), Neuromodulation, 27, 557 - 564

Adipose Tissue in Cardiovascular Disease: From Basic Science to Clinical Translation

Polkinghorne MD. et al, (2024), Annual Review of Physiology, 86, 175 - 198

Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers

Antoniades C. et al, (2023), European Heart Journal, 44, 3827 - 3844

Assessment of Myocardial 18F-FDG Uptake at PET/CT in Asymptomatic SARS-CoV-2-vaccinated and Nonvaccinated Patients

Nakahara T. et al, (2023), Radiology, 308

High resolution photon counting CT permits direct visualisation of directional deep brain stimulation lead segments and markers

Manfield J. et al, (2023), Brain Stimulation, 16, 1276 - 1277

Role of Human Epicardial Adipose Tissue–Derived miR-92a-3p in Myocardial Redox State

Carena MC. et al, (2023), Journal of the American College of Cardiology, 82, 317 - 332

LegoNet: alternating model blocks for medical image segmentation

Sobirov I. et al, (2023)

Deep-Learning for Epicardial Adipose Tissue Assessment With Computed Tomography: Implications for Cardiovascular Risk Prediction

West HW. et al, (2023), JACC: Cardiovascular Imaging, 16, 800 - 816

Assessment of Cardiac Energy Metabolism, Function, and Physiology in Patients With Heart Failure Taking Empagliflozin: The Randomized, Controlled EMPA-VISION Trial

Hundertmark MJ. et al, (2023), Circulation, 147, 1654 - 1669

Using artificial intelligence to study atherosclerosis, predict risk and guide treatments in clinical practice

Antoniades C. et al, (2023), European Heart Journal, 44, 437 - 439

Lectin-Like Oxidized Low-Density Lipoprotein Receptor 1 Inhibition in Type 2 Diabetes: Phase 1 Results

Vavere AL. et al, (2023), Journal of the American Heart Association, 12

PHACTR1 modulates vascular compliance but not endothelial function: a translational study

Wood A. et al, (2023), Cardiovascular Research, 119, 599 - 610

Genetic variability of lipoprotein(a) controls vascular inflammation/redox signalling and predicts adverse cardiovascular outcomes in coronary artery disease N.

Polkinghorne MD. et al, (2023), EUROPEAN HEART JOURNAL, 44

Human epicardial adipose tissue-secreted miR-92a-3p regulates myocardial redox state via paracrine signalling: implications for cardiovascular clinical outcomes

Badi I. et al, (2023), EUROPEAN HEART JOURNAL, 44

Lipoprotein(a) Regulates Vascular Redox State and Predicts Adverse Cardiovascular Outcomes in Coronary Artery Disease

Polkinghorne MD. et al, (2023), CIRCULATION, 148

The Role of Perivascular Fat in the Diagnosis and Prognosis of Atherosclerosis

Polkinghorne M. et al, (2023), CardioMetabolic Syndrome Journal, 3, 8 - 8

Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications

Akoumianakis I. et al, (2022), Nature Reviews Cardiology, 19, 783 - 797

Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation

Tousoulis D. et al, (2022), Cardiovascular Research, 118, 3171 - 3182

Noninvasive Plaque Imaging to Accelerate Coronary Artery Disease Drug Development

Figtree GA. et al, (2022), Circulation, 146, 1712 - 1727

Pericardial adiposity is independently linked to adverse cardiovascular phenotypes: a CMR study of 42 598 UK Biobank participants

Ardissino M. et al, (2022), European Heart Journal Cardiovascular Imaging, 23, 1471 - 1481

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

Kotanidis CP. et al, (2022), The Lancet Digital Health, 4, e705 - e716

Novel Biomarkers for Risk Stratification in NSTE-ACS: Is There a Place for Cathepsin S?

Antoniades C. and Polkinghorne MD., (2022), Journal of the American College of Cardiology, 80, 1011 - 1013

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study

Evans RA. et al, (2022), The Lancet Respiratory Medicine, 10, 761 - 775

MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity

Katsouda A. et al, (2022), Journal of Experimental Medicine, 219

Non-canonical WNT signalling in cardiovascular disease: mechanisms and therapeutic implications

Akoumianakis I. et al, (2022), Nature Reviews Cardiology, 19, 783 - 797

Erratum: Uncovering the skeleton in the heart: an unusual case of mitral annular calcification extending to the left ventricular myocardium (European Heart Journal - Cardiovascular Imaging (2020) 21:11 (1301) DOI: 10.1093/ehjci/jeaa121)

Nikolaidou C. et al, (2022), European Heart Journal Cardiovascular Imaging, 23

Visceral adipose tissue phenotype and hypoadiponectinemia are associated with aortic Fluorine-18 fluorodeoxyglucose uptake in patients with familial dyslipidemias

Toutouzas K. et al, (2022), Journal of Nuclear Cardiology, 29, 1405 - 1414

Graft flow assessment and early coronary artery bypass graft failure: A computed tomography analysis

Dalessio A. et al, (2022), Interactive Cardiovascular and Thoracic Surgery, 34, 974 - 981

Erratum: Uncovering the skeleton in the heart: an unusual case of mitral annular calcification extending to the left ventricular myocardium (European Heart Journal - Cardiovascular Imaging (2020) 21:11 (1301) DOI: 10.1093/ehjci/jeaa121)

Nikolaidou C. et al, (2022), European Heart Journal Cardiovascular Imaging, 23

Cardiovascular risk stratification by coronary computed tomography angiography imaging: Current state-of-The-Art

Antonopoulos AS. et al, (2022), European Journal of Preventive Cardiology, 29, 608 - 624

Biomarkers of Vascular Inflammation for Cardiovascular Risk Prognostication: A Meta-Analysis

Antonopoulos AS. et al, (2022), JACC: Cardiovascular Imaging, 15, 460 - 471

ESC CVD Prevention Guidelines 2021: Improvements, controversies, and opportunities

Antoniades C. and West HW., (2022), Cardiovascular Research, 118, E17 - E19

Effects of canagliflozin on human myocardial redox signalling: Clinical implications

Kondo H. et al, (2021), European Heart Journal, 42, 4947 - 4960

Standardized measurement of coronary inflammation using cardiovascular computed tomography: Integration in clinical care as a prognostic medical device

Oikonomou EK. et al, (2021), Cardiovascular Research, 117, 2677 - 2690

Molecular imaging—The first visual themed issue published in the British Journal of Pharmacology

Maffia P. et al, (2021), British Journal of Pharmacology, 178, 4213 - 4215

CT coronary angiography-guided cardiovascular risk screening in asymptomatic patients: is it time?

(2021), Clinical Radiology, 76, 801 - 811

Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study

Evans RA. et al, (2021), The Lancet Respiratory Medicine, 9, 1275 - 1287

Perivascular fat imaging by computed tomography (CT): a virtual guide

Kotanidis CP. and Antoniades C., (2021), British Journal of Pharmacology, 178, 4270 - 4290

Acute exposure to diesel affects inflammation and vascular function

Tousoulis D. et al, (2021), European Journal of Preventive Cardiology, 28, 1192 - 1200

Coronary CT angiography as an 'one-stop shop' to detect the high-risk plaque and the vulnerable patient

Antoniades C. and West HW., (2021), European Heart Journal, 42, 3853 - 3855

Acute exposure to diesel affects inflammation and vascular function.

Tousoulis D. et al, (2021), Eur J Prev Cardiol, 28, 1192 - 1200

A phenomapping-derived tool to personalize the selection of anatomical vs. functional testing in evaluating chest pain (ASSIST)

Oikonomou EK. et al, (2021), European Heart Journal, 42, 2536 - 2548

Inflammatory mechanisms in covid-19 and atherosclerosis: Current pharmaceutical perspectives

Sagris M. et al, (2021), International Journal of Molecular Sciences, 22

Cardiac magnetic resonance to detect the underlying substrate in patients with frequent idiopathic ventricular arrhythmias

Nikolaidou C. et al, (2021), Diagnostics, 11

Reply to: Quantification of perivascular inflammation does not provide incremental prognostic value over myocardial perfusion imaging and calcium scoring

Antonopoulos AS. and Antoniades C., (2021), European Journal of Nuclear Medicine and Molecular Imaging, 48, 1707 - 1708

Development, validation, and implementation of biomarker testing in cardiovascular medicine state-of-the-art: Proceedings of the European Society of Cardiology-Cardiovascular Round Table

Elliott P. et al, (2021), Cardiovascular Research, 117, 1248 - 1256

Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

Raman B. et al, (2021), Eclinicalmedicine, 31

The year in cardiovascular medicine 2020: Digital health and innovation

Antoniades C. et al, (2021), Russian Journal of Cardiology, 26, 114 - 124

Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease

Oikonomou EK. et al, (2020), Cardiovascular Research, 116, 2040 - 2054

Uncovering the skeleton in the heart: An unusual case of mitral annular calcification extending to the left ventricular myocardium

Nikolaidou C. et al, (2020), European Heart Journal Cardiovascular Imaging, 21

A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications

Oikonomou E. et al, (2020), Atherosclerosis, 309, 16 - 26

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition

Akoumianakis I. et al, (2020), Science Translational Medicine, 12

Preventing treatment failures in coronary artery disease: What can we learn from the biology of in-stent restenosis, vein graft failure, and internal thoracic arteries?

Spadaccio C. et al, (2020), Cardiovascular Research, 116, 505 - 519

Imaging residual inflammatory cardiovascular risk

Antoniades C. et al, (2020), European Heart Journal, 41, 748 - 758

Selfies in cardiovascular medicine: Welcome to a new era of medical diagnostics

Kotanidis CP. and Antoniades C., (2020), European Heart Journal, 41, 4412 - 4414

Plasma signature of apoptotic microvesicles is associated with endothelial dysfunction and plaque rupture in acute coronary syndromes

Zacharia E. et al, (2020), Journal of Molecular and Cellular Cardiology, 138, 110 - 114

Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge

Raman B. et al, (2020)

Very low calorie diets are associated with transient ventricular impairment before reversal of diastolic dysfunction in obesity

Rayner JJ. et al, (2019), International Journal of Obesity, 43, 2536 - 2544

Scientists on the Spot: Non-coding RNAs and heart failure

Antoniades C. and Condorelli G., (2019), Cardiovascular Research, 115, e164 - e165

A novel machine learning-derived radiotranscriptomic signature of perivascular fat improves cardiac risk prediction using coronary CTangiography

Oikonomou EK. et al, (2019), European Heart Journal, 40, 3529 - 3543

Cardiac Computed Tomography: Assessment of Coronary Inflammation and Other Plaque Features

Oikonomou EK. et al, (2019), Arteriosclerosis Thrombosis and Vascular Biology, 39, 2207 - 2219

Arterial Grafts for Coronary Bypass: A Critical Review After the Publication of ART and RADIAL

Gaudino M. et al, (2019), Circulation, 140, 1273 - 1284

Detecting Coronary Inflammation With Perivascular Fat Attenuation Imaging: Making Sense From Perivascular Attenuation Maps

Antoniades C. and Shirodaria C., (2019), Jacc Cardiovascular Imaging, 12, 2011 - 2014

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

Akoumianakis I. et al, (2019), Science Translational Medicine, 11

Association of Biologic Therapy with Coronary Inflammation in Patients with Psoriasis as Assessed by Perivascular Fat Attenuation Index

Elnabawi YA. et al, (2019), JAMA Cardiology, 4, 885 - 891

State-of-the-art review article. Atherosclerosis affecting fat: What can we learn by imaging perivascular adipose tissue?

Antoniades C. et al, (2019), Journal of Cardiovascular Computed Tomography, 13, 288 - 296

Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data

Oikonomou EK. et al, (2018), The Lancet, 392, 929 - 939

Cardiac Magnetic Resonance Imaging of Epicardial and Intramyocardial Adiposity as an Early Sign of Myocardial Disease

Antonopoulos AS. and Antoniades C., (2018), Circulation. Cardiovascular imaging, 11

Comparison of graft patency following coronary artery bypass grafting in the left versus the right coronary artery systems: A systematic review and meta-analysis

Pinho-Gomes AC. et al, (2018), European Journal of Cardio-thoracic Surgery, 54, 221 - 228

Off-pump coronary artery bypass grafting: 30 years of debate

Gaudino M. et al, (2018), Journal of the American Heart Association, 7

Development and Validation of a Clinical Score for Cardiovascular Risk Stratification of Long-Term Childhood Cancer Survivors

Oikonomou EK. et al, (2018), Oncologist, 23, 965 - 973

Immunometabolic Regulation of Vascular Redox State: The Role of Adipose Tissue

Oikonomou EK. and Antoniades C., (2018), Antioxidants and Redox Signaling, 29, 313 - 336

Mechanisms of testosterone deficiency-related endothelial dysfunction: Invited commentary for the Hellenic Journal of Cardiology on: Tsikas et al. “Associations between asymmetric dimethylarginine, nitrite-dependent renal carbonic anhydrase activity and plasma testosterone levels in hypogonadal men”

Antonopoulos AS. and Antoniades C., (2018), Hellenic Journal of Cardiology, 59, 207 - 208

Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia

Toutouzas K. et al, (2018), Journal of Clinical Lipidology, 12, 33 - 43

Predictive value of telomere length on outcome following acute myocardial infarction: Evidence for contrasting effects of vascular vs. blood oxidative stress

Margaritis M. et al, (2017), European Heart Journal, 38, 3094 - 3104

A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption

Lee R. et al, (2017), Clinical Proteomics, 14

Scientists of tomorrow at the frontiers of cardiovascular biology 2016 in florence: Translating basic science into clinical practice is the next frontier

Antoniades C. and Vilahur G., (2016), Cardiovascular Research, 111, 120 - 122

Expert consensus document: Defining the major health modifiers causing atrial fibrillation: A roadmap to underpin personalized prevention and treatment

Fabritz L. et al, (2016), Nature Reviews Cardiology, 13, 230 - 237

Differences in arterial stiffness and target organ damage between native Greek patients and immigrants from Eastern European countries with essential hypertension

Katsi V. et al, (2015), International Angiology, 34, 407 - 412

Adiponectin as a link between type 2 diabetes and vascular NADPH oxidase activity in the human arterial wall: The regulatory role of perivascular adipose tissue

Antonopoulos AS. et al, (2015), Diabetes, 64, 2207 - 2219

Statins as Pleiotropic Modifiers of Vascular Oxidative Stress and Inflammation

Psarros C. et al, (2015), Journal of Critical Care Medicine, 1, 43 - 54

Impact of folic acid administration in homocysteine levels, inflammation and in atherosclerotic plaque area in apoE deficient mice

Tousoulis D. et al, (2014), International Journal of Cardiology, 177, 696 - 697

Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease

Antonopoulos AS. et al, (2014), Arteriosclerosis, Thrombosis, and Vascular Biology

Combined effects of smoking and interleukin-6 and C-reactive protein genetic variants on endothelial function, inflammation, thrombosis and incidence of coronary artery disease

Hatzis G. et al, (2014), International Journal of Cardiology, 176, 254 - 257

Combined effects of smoking and interleukin-6 and C-reactive protein genetic variants on endothelial function, inflammation, thrombosis and incidence of coronary artery disease

Hatzis G. et al, (2014), International Journal of Cardiology

Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease

Antonopoulos AS. et al, (2014), Arteriosclerosis Thrombosis and Vascular Biology, 34, 2151 - 2159

Combined effects of fibrinogen genetic variability on atherosclerosis in patients with or without stable angina pectoris: Focus on the coagulation cascade and endothelial function

Papageorgiou N. et al, (2013), International Journal of Cardiology, 168, 4602 - 4607

Inflammation and right ventricle: The hunting of the missing link

Papageorgiou N. et al, (2013), International Journal of Cardiology, 168, 3152 - 3154

The role of C-reactive protein genetic variability in the onset of carotid artery disease and renal function impairment in patients with diabetes mellitus type 2

Papaoikonomou S. et al, (2013), International Journal of Cardiology, 168, 4331 - 4332

Artifactual elevation of plasma sCD40L by residual platelets in patients with coronary artery disease

Lee R. et al, (2013), International Journal of Cardiology, 168, 1648 - 1650

The impact of G5665T polymorphismof endothelin-1 gene, on endothelin-1 levels and left ventricular function in ischemic heart disease

Tousoulis D. et al, (2013), International Journal of Cardiology, 168, 1568 - 1569

Genetic variability on adiponectin gene affects myocardial infarction risk: The role of endothelial dysfunction

Antonopoulos AS. et al, (2013), International Journal of Cardiology, 168, 326 - 330

Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels

Margaritis M. et al, (2013), Circulation, 127, 2209 - 2221

Improved limb perfusion and neoangiogenesis after intramuscular erythropoietin infusion in experimental model of limb ischemia

Tousoulis D. et al, (2013), International Journal of Cardiology, 165, 195 - 197

Flow mediated dilation and carotid intima media thickness: Clinical markers or just research tools?

Tousoulis D. et al, (2013), International Journal of Cardiology, 163, 226 - 228

Heparin administration leads to rapid decrease in plasma matrix metalloproteinase-9

Lee R. et al, (2013), International Journal of Cardiology, 163, 212 - 213

Combined effects of fibrinogen genetic variability on atherosclerosis in patients with or without stable angina pectoris: Focus on the coagulation cascade and endothelial function

Papageorgiou N. et al, (2013), International Journal of Cardiology

The impact of G5665T polymorphism of endothelin-1 gene, on endothelin-1 levels and left ventricular function in ischemic heart disease

Tousoulis D. et al, (2013), International Journal of Cardiology

The role of C-reactive protein genetic variability in the onset of carotid artery disease and renal function impairment in patients with diabetes mellitus type 2

Papaoikonomou S. et al, (2013), International Journal of Cardiology

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

Cunnington C. et al, (2012), Circulation, 125, 1356 - 1366

Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta

Brili S. et al, (2012), Heart, 98, 325 - 329

Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery: Effects of short-term pre-operative statin treatment

Antoniades C. et al, (2012), Journal of the American College of Cardiology, 59, 60 - 70

Systemic and vascular oxidation limits efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

Cunnington C. et al, (2012), Circulation

Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease

Cunnington C. et al, (2012), Circulation, 125, 1356 - 1366

Improved limb perfusion and neoangiogenesis after intramuscular erythropoietin infusion in experimental model of limb ischemia

Tousoulis D. et al, (2012), International Journal of Cardiology

Early diagnosis of perioperative myocardial infarction after coronary bypass grafting: A study using biomarkers and cardiac magnetic resonance imaging

Lim CCS. et al, (2011), Annals of Thoracic Surgery, 92, 2046 - 2053

Fibrinogen and cardiovascular disease: Genetics and biomarkers

Tousoulis D. et al, (2011), Blood Reviews, 25, 239 - 245

Response to asymmetrical dimethylarginine, oxidative stress, and atherosclerosis

Antoniades C. et al, (2011), Hypertension, 58

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis

Antoniades C. et al, (2011), Circulation, 124, 1860 - 1870

Effects of the Ala379Val polymorphism of lipoprotein-associated phospholipase A2 on thrombosis and inflammation in hypertensive patients

Kardara D. et al, (2011), International Journal of Cardiology, 152, 247 - 249

Do endothelial progenitor cells modify our strategy to treat risk factors?

Tousoulis D. et al, (2011), International Journal of Cardiology, 152, 95 - 97

C-reactive protein and endothelial dysfunction: Gazing at the coronaries

Tousoulis D. et al, (2011), International Journal of Cardiology, 152, 1 - 3

Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: Implications for the antiarrhythmic effect of statins

Reilly SN. et al, (2011), Circulation, 124, 1107 - 1117

Atrial sources of reactive oxygen species vary with the duration and substrate of atrial fibrillation: implications for the antiarrhythmic effect of statins.

Reilly SN. et al, (2011), Circulation, 124, 1107 - 1117

Methionine-induced homocysteinemia impairs endothelial function in hypertensives: The role of asymmetrical dimethylarginine and antioxidant vitamins

Tousoulis D. et al, (2011), American Journal of Hypertension, 24, 936 - 942

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin- mediated endothelial nitric oxide synthase coupling

Antoniades C. et al, (2011), Circulation, 124, 335 - 345

Role of asymmetrical dimethylarginine in inflammation-induced endothelial dysfunction in human atherosclerosis

Antoniades C. et al, (2011), Hypertension, 58, 93 - 98

Endothelial nitric oxide synthase in the vascular wall: Mechanisms regulating its expression and enzymatic function

Demosthenous M. et al, (2011), Artery Research, 5, 37 - 49

Combined effects of atorvastatin and metformin on glucose-induced variations of inflammatory process in patients with diabetes mellitus

Tousoulis D. et al, (2011), International Journal of Cardiology, 149, 46 - 49

Novel methodology for the detection of exercise-induced myocardial wall motion abnormalities by surface electrocardiogram during exercise test

Michaelides AP. et al, (2011), Journal of Electrocardiology, 44, 377 - 382

With the "universal definition," measurement of creatine kinase-myocardial band rather than troponin allows more accurate diagnosis of periprocedural necrosis and infarction after coronary intervention

Lim CCS. et al, (2011), Journal of the American College of Cardiology, 57, 653 - 661

The significance of right-sided chest leads in exercise testing for the detection of right ventricular dysfunction post myocardial infarction of the inferior wall

Michaelides A. et al, (2011), International Journal of Cardiology, 146, 330 - 333

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis

Antoniades C. et al, (2011), Circulation

Effects of atorvastatin on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young subjects with successfully repaired coarctation of aorta

Brili S. et al, (2011), Heart

Effects of the Ala379Val polymorphism of lipoprotein-associated phospholipase A2 on thrombosis and inflammation in hypertensive patients

Kardara D. et al, (2011), International Journal of Cardiology

Treatment of recurrent vein graft "stent-in-stent" re-stenosis guided by optical coherence tomography

Lee R. et al, (2011), International Journal of Cardiology

OCT characteristics of saphenous vein graft atherosclerosis

Adlam D. et al, (2011), JACC: Cardiovascular Imaging, 4, 807 - 809

Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling

Antoniades C. et al, (2011), Circulation

Comparative effects of rosuvastatin and allopurinol on circulating levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with chronic heart failure

Tousoulis D. et al, (2010), International Journal of Cardiology, 145, 438 - 443

ST-segment depression in hyperventilation indicates a false positive exercise test in patients with mitral valve prolapse

Liakos CI. et al, (2010), Cardiology Research and Practice, 1

Preoperative atorvastatin treatment in CABG patients rapidly improves vein graft redox state by inhibition of Rac1 and NADPH-oxidase activity

Antoniades C. et al, (2010), Circulation, 122

A 31 year old woman with essential hypertension grade III and branch retinal vein occlusion with homozygous C677T MTHFR hyperhomocysteinemia and high Lp(a) levels

Katsi V. et al, (2010), International Journal of Cardiology, 143

Impact of 6 weeks of treatment with low-dose metformin and atorvastatin on glucose-induced changes of endothelial function in adults with newly diagnosed type 2 diabetes mellitus: A single-blind study

Tousoulis D. et al, (2010), Clinical Therapeutics, 32, 1720 - 1728

Rosuvastatin but not ezetimibe improves endothelial function in patients with heart failure, by mechanisms independent of lipid lowering

Gounari P. et al, (2010), International Journal of Cardiology, 142, 87 - 91

Genetic polymorphism on type 2 receptor of angiotensin II, modifies cardiovascular risk and systemic inflammation in hypertensive males

Tousoulis D. et al, (2010), American Journal of Hypertension, 23, 237 - 242

The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals

Tousoulis D. et al, (2010), Journal of Hypertension, 28, 925 - 930

Do endothelial progenitor cells modify our strategy to treat risk factors?

Tousoulis D. et al, (2010), International Journal of Cardiology

Acute effects of different types of oil consumption on endothelial function, oxidative stress status and vascular inflammation in healthy volunteers

Tousoulis D. et al, (2010), British Journal of Nutrition, 103, 43 - 49

Electrocardiographic criteria for detecting coronary artery disease in hypertensive patients with ST-segment changes during exercise testing

Michaelides AP. et al, (2009), Journal of Electrocardiology, 42, 405 - 409

Inflammatory and thrombotic processes are associated with vascular dysfunction in children with familial hypercholesterolemia

Charakida M. et al, (2009), Atherosclerosis, 204, 532 - 537

Relationship between the pharmacokinetics of Levosimendan and its effects on cardiovascular system

Antoniades C. et al, (2009), Current Drug Metabolism, 10, 95 - 103

Antidepressive treatment as a modulator of inflammatory process in patients with heart failure: Effects on proinflammatory cytokines and acute phase protein levels

Tousoulis D. et al, (2009), International Journal of Cardiology, 134, 238 - 243

The impact of ezetimibe and high-dose of statin treatment on LDL levels in patients with heterozygous familial hypercholesterolemia

Pitsavos C. et al, (2009), International Journal of Cardiology, 134, 280 - 281

MTHFR 677 C>T polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis

Antoniades C. et al, (2009), Circulation, 119, 2507 - 2515

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: Implications for endothelial function in human atherosclerosis

Antoniades C. et al, (2009), European Heart Journal, 30, 1142 - 1150

Early initiation of low-dose atorvastatin treatment after an acute ST-elevated myocardial infarction, decreases inflammatory process and prevents endothelial injury and activation

Stefanadi E. et al, (2009), International Journal of Cardiology, 133, 266 - 268

ST segment "hump" during exercise testing and the risk of sudden cardiac death in patients with hypertrophic cardiomyopathy

Michaelides AP. et al, (2009), Annals of Noninvasive Electrocardiology, 14, 158 - 164

Targeting redox signaling in the vascular wall: From basic science to clinical practice

Antoniades C. et al, (2009), Current Pharmaceutical Design, 15, 329 - 342

Relation of Preoperative Radial Artery Flow-Mediated Dilatation to Nitric Oxide Bioavailability in Radial Artery Grafts Used in Off-Pump Coronary Artery Bypass Grafting

Antoniades C. et al, (2009), American Journal of Cardiology, 103, 216 - 220

Role of inflammation and oxidative stress in endothelial progenitor cell function and mobilization: Therapeutic implications for cardiovascular diseases

Tousoulis D. et al, (2008), Atherosclerosis, 201, 236 - 247

Beneficial effects of statin treatment after myocardial infarction: Is progenitor cell mobilization the missing link?

Tousoulis D. et al, (2008), International Journal of Cardiology, 130, 301 - 303

Common community infections and the risk for coronary artery disease and acute myocardial infarction: Evidence for chronic over-expression of tumor necrosis factor alpha and vascular cells adhesion molecule-1

Nikolopoulou A. et al, (2008), International Journal of Cardiology, 130, 246 - 250

Correlation of modification of heart rate recovery with adaptation to myocardial ischemia in a model of sequential exercise testings

Michaelides AP. et al, (2008), Annals of Noninvasive Electrocardiology, 13, 364 - 370

Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes

Tousoulis D. et al, (2008), Trends in Molecular Medicine, 14, 441 - 449

Common Genetic Polymorphisms and Haplotypes of Fibrinogen Alpha, Beta, and Gamma Chains Affect Fibrinogen Levels and the Response to Proinflammatory Stimulation in Myocardial Infarction Survivors. The AIRGENE Study

Jacquemin B. et al, (2008), Journal of the American College of Cardiology, 52, 941 - 952

Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk

Doehring A. et al, (2008), Mutation Research Reviews in Mutation Research, 659, 195 - 201

Smoking in Asians: It doesn't stop at vascular endothelium

Antoniades C. et al, (2008), International Journal of Cardiology, 128, 151 - 153

Selective Serotonin Reuptake Inhibitors Modify the Effect of β-Blockers on Long-Term Survival of Patients With End-Stage Heart Failure and Major Depression

Tousoulis D. et al, (2008), Journal of Cardiac Failure, 14, 456 - 464

Acute effects of different alcoholic beverages on vascular endothelium, inflammatory markers and thrombosis fibrinolysis system

Tousoulis D. et al, (2008), Clinical Nutrition, 27, 594 - 600

GCH1 Haplotype Determines Vascular and Plasma Biopterin Availability in Coronary Artery Disease. Effects on Vascular Superoxide Production and Endothelial Function

Antoniades C. et al, (2008), Journal of the American College of Cardiology, 52, 158 - 165

Valve replacement for Brucella endocarditis: Two case reports

Koumallos N. et al, (2008), International Journal of Cardiology, 127, e83 - e85

Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals

Siasos G. et al, (2008), International Journal of Cardiology, 126, 394 - 399

Methionine-Loading Rapidly Impairs Endothelial Function, by Mechanisms Independent of Endothelin-1: Evidence for an Association of Fasting Total Homocysteine with Plasma Endothelin-1 Levels

Tousoulis D. et al, (2008), Journal of the American College of Nutrition, 27, 379 - 386

New biochemical markers in acute coronary syndromes

Tousoulis D. et al, (2008), Current Medicinal Chemistry, 15, 1288 - 1296

Heart regeneration: what cells to use and how?

Tousoulis D. et al, (2008), Current Opinion in Pharmacology, 8, 211 - 218

Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patientswith coronary artery disease

Tousoulis D. et al, (2008), International Journal of Cardiology, 124, 127 - 129

Effects of Ramipril on Endothelial Function and the Expression of Proinflammatory Cytokines and Adhesion Molecules in Young Normotensive Subjects With Successfully Repaired Coarctation of Aorta. A Randomized Cross-Over Study

Brili S. et al, (2008), Journal of the American College of Cardiology, 51, 742 - 749

Statins ameliorate atherosclerosis induced by inhibition of nitric oxide synthase: Another novel vascular protective mechanism?

Tousoulis D. et al, (2008), International Journal of Cardiology, 123, 91 - 93

Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation

Antoniades C. et al, (2007), Circulation, 116, 2851 - 2859

Evidence that non-lipid cardiovascular risk factors are associated with high prevalence of coronary artery disease in patients with heterozygous familial hypercholesterolemia or familial combined hyperlipidemia

Skoumas I. et al, (2007), International Journal of Cardiology, 121, 178 - 183

Effects of insulin dependence on inflammatory process, thrombotic mechanisms and endothelial function, in patients with type 2 diabetes mellitus and coronary atherosclerosis

Antoniades C. et al, (2007), Clinical Cardiology, 30, 295 - 300

Nitric oxide-releasing aspirin: Will it say NO to atherothrombosis?

Antoniades C. et al, (2007), International Journal of Cardiology, 118, 170 - 172

Global improvement of vascular function and redox state with low-dose folic acid: Implications for folate therapy in patients with coronary artery disease

Shirodaria C. et al, (2007), Circulation, 115, 2262 - 2270

Effects of Endothelial Nitric Oxide Synthase Gene Polymorphisms on Oxidative Stress, Inflammatory Status, and Coronary Atherosclerosis: An Example of a Transient Phenotype

Antoniades C. et al, (2007), Journal of the American College of Cardiology, 49

Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus

Lee JMS. et al, (2007), Diabetes and Vascular Disease Research, 4, 44 - 48

Differences in inflammatory and thrombotic markers between unstable angina and acute myocardial infarction

Tousoulis D. et al, (2007), International Journal of Cardiology, 115, 203 - 207

Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus

Tousoulis D. et al, (2007), Heart, 93, 244 - 246

Cold pressor test as a marker for the detection of early stage coronary atherosclerosis

Tousoulis D. et al, (2007), International Journal of Cardiology, 115, 120 - 122

Potential role of endothelial progenitor cells in the pathophysiology of heart failure: Clinical implications and perspectives

Andreou I. et al, (2006), Atherosclerosis, 189, 247 - 254

Asymmetrical dimethylarginine regulates endothelial function in methionine-induced but not in chronic homocystinemia in humans: Effect of oxidative stress and proinflammatory cytokines

Antoniades C. et al, (2006), American Journal of Clinical Nutrition, 84, 781 - 788

5-Methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: Effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling

Antoniades C. et al, (2006), Circulation, 114, 1193 - 1201

Genetic Polymorphisms of Platelet Glycoprotein Ia and the Risk for Premature Myocardial Infarction. Effects on the Release of sCD40L During the Acute Phase of Premature Myocardial Infarction

Antoniades C. et al, (2006), Journal of the American College of Cardiology, 47, 1959 - 1966

Effects of lipid profile on forearm hyperemic response in young subjects

Antoniades C. et al, (2006), Hellenic Journal of Cardiology, 47, 152 - 157

The impact of early administration of low-dose atorvastatin treatment on inflammatory process, in patients with unstable angina and low cholesterol level

Tousoulis D. et al, (2006), International Journal of Cardiology, 109, 48 - 52

Statins and antioxidant vitamins: Should co-administration be avoided? [10]

Tousoulis D. et al, (2006), Journal of the American College of Cardiology, 47

Genetic polymorphisms G894T on the eNOS gene is associated with endothelial function and vWF levels in premature myocardial infarction survivors

Antoniades C. et al, (2006), International Journal of Cardiology, 107, 95 - 100

Effects of early administration of atorvastatin treatment on thrombotic process in normocholesterolemic patients with unstable angina

Tousoulis D. et al, (2006), International Journal of Cardiology, 106, 333 - 337

Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure

Tousoulis D. et al, (2005), European Journal of Heart Failure, 7, 1126 - 1132

Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major

Aggeli C. et al, (2005), International Journal of Cardiology, 105, 80 - 84

Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina

Tousoulis D. et al, (2005), Heart, 91, 1319 - 1323

Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction

Antoniades C. et al, (2005), Journal of the American College of Cardiology, 46, 1101 - 1109

Letter regarding article by Becker et al, "Hyperhomocysteinemia, a cardiac metabolic disease: role of nitric oxide and the p22phox subunit of NADPH oxidase".

Antoniades C. et al, (2005), Circulation, 112

Effects of atorvastatin on reactive hyperaemia and the thrombosis- fibrinolysis system in patients with heart failure

Tousoulis D. et al, (2005), Heart, 91, 27 - 31

Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response

Antoniades C. et al, (2004), American Journal of Cardiology, 94, 1181 - 1184

Evidence for association between endothelial nitric oxide synthase gene polymorphism (G894T) and inflammatory markers: The ATTICA study

Chrysohoou C. et al, (2004), American Heart Journal, 148, 733 - 738

Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: The effects of vitamins C

Antoniades C. et al, (2004), Diabetic Medicine, 21, 552 - 558

Effects of levosimendan on circulating pro-inflammatory cytokines and soluble apoptosis mediators in patients with decompensated advanced heart failure

Parissis JT. et al, (2004), American Journal of Cardiology, 93, 1309 - 1312

Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy

Tentolouris C. et al, (2004), International Journal of Cardiology, 94, 301 - 305

Oxidative Stress, Antioxidant Vitamins, and Atherosclerosis: From Basic Research to Clinical Practice

Antoniades C. et al, (2003), Herz, 28, 628 - 638

Vitamin C affects thrombosis/fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery disease

Tousoulis D. et al, (2003), Diabetes Care, 26, 2749 - 2753

Cardiovascular Science: Cardiovascular Technology, AI and Data

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Charalambos Antoniades

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