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This course is scheduled once a year in Hilary term.

Please note this course takes place over five days and participants will be expected to attend all sessions:

The NMR course consists of lectures and practical sessions. No prior knowledge of NMR is assumed. For further information contact (christina.redfield@bioch.ox.ac.uk)

 

Monday February 4th 9:30am - 5pm

Introduction to Biomolecular NMR and Assignment of Protein NMR Spectra

 

Tuesday February 5th 9:30am - 5pm

Assignment of Protein NMR Spectra

Protein Structure Determination by NMR

 

Wednesday February 6th 9:30am - 5pm

NMR of Intrinsically Disordered Proteins 

NMR of Nucleic Acids

Protein Dynamics

 

Thursday February 7th 9:30am - 5pm

NMR of Oligosaccharides

Biological Solid-state NMR

Protein-ligand Interactions by NMR

 

Friday February 8th 9:30am - 1pm

Solid-state NMR for Protein Structure Determination

Solution NMR of Membrane Proteins

 

 

COURSE AIMS

The course will focus on the application of solution-state NMR to the study of different types of biomolecules. The emphasis is on solution-state NMR studies of proteins but applications to nucleic acids and oligosaccharides will also be presented. In addition, more advanced topics including residual dipolar couplings, dynamics, solid-state biomolecular NMR and protein-ligand interations will be introduced.

 

COURSE FORMAT

Topics to be covered include:


1) Introduction to Biomolecular NMR
2) Assignment of Protein NMR Spectra
3) Assignment using 15N and 13C Labeling
4) Data Harvesting and Structure Determination I
5) Residual Dipolar Couplings
6) Data Harvesting and Structure Determination II
7) Protein Dynamics
8) Using NMR to study Intrinsically Disordered Proteins
9) Using NMR Spectroscopy to Study Protein Folding and Partially Folded Proteins
10) Protein-ligand interactions by NMR
11) Solution NMR Studies of Membrane Proteins
12) Principles and applications of biological solid state NMR
13) Solid-state NMR for protein structure determination
14) NMR of Nucleic Acids
15) Use of NMR for identification and conformational determination of oligosaccharides and related alkaloids

 

COURSE LENGTH 

The course will run for 5 days and include lectures and practical sessions.

 

PARTICIPANT NUMBERS 

Maximum 25

Terms and Conditions

Please read the Terms and Conditions for course booking and attendance.

*** NEW COURSES ***

Careers workshops for research students and research staff in Hilary term - run by the Careers Service

iSkills for the Medical Sciences Division: Introduction to Mendeley (run by Bodleian iSkills) - book now for places during January-April.

Pathways for women researchers aiming for an academic career in sciencerun by the MPLS division

Graduate skills training courses available in early February at the Department for Continuing Education - spaces limited so book now

In collaboration with IT: R: Kick off – For those interested in learning what R can do to analyse and visualise data – 1 and 8 February

In collaboration with IT: R: Preparing for your data analysis – Basic concepts in exploratory data analysis and statistical modelling using R – 15 February and 7 March

In collaboration with IT: R: Visualising your data – For those who would like develop their skills in visualising data using R – 15 March

Writing a transfer report 23 January 2019

Writing a thesis 5 March 2019

Writing a thesis 12 March 2019

Writing a thesis 19 March 2019

Mixing it up mixed research methods course at the Department for Continuing Education (free for Oxford DPhil students) - 23 April to 11 June

Forthcoming events

Introduction to statistics (Group A)

Tuesday, 19 February 2019 to Tuesday, 12 March 2019, 9.30am - 12.30pm

Introduction to statistics (Group B)

Thursday, 21 February 2019 to Thursday, 14 March 2019, 1.30pm - 4.30pm

Viva preparation

Monday, 04 March 2019, 2pm to 5pm

Writing a thesis

Tuesday, 05 March 2019, 2pm to 5pm

Experimental Design: the Good, the Bad and the Ugly

Wednesday, 06 March 2019, 9am to 5pm

Managing your supervisor

Thursday, 07 March 2019, 10am to 1pm