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Wellcome Trust Senior Research Fellow

Associate Director, Wellcome Centre for Integrative Neuroimaging (WIN)

Co-Director, WIN Physics Group

Major funding sources

  • Wellcome Trust
  • Engineering and Physical Sciences Research Council (EPSRC UK)
  • Medical Research Council (MRC UK)
  • European Research Council (ERC)

Karla Miller

Professor of Biomedical Engineering

I develop novel methods for acquiring, reconstructing and analyzing MRI scans of the brain.

My early research focused on techniques for studying brain function and connectivity. Much of my current work characterises  tissue microstructure with MRI in conjunction with complementary technologies like microscopy. I helped to establish the UK Biobank brain imaging protocol, and am undertaking studies with this data as an external user.

MRI is a powerful method for studying the human brain non-invasively. I am leading several projects that aim to advance the state of the art in MRI through improvements in signal sensitivity and specificity. My group is developing methods to measure aspects of tissue microstructure that are central to neuronal health and disease. We further aim to improve our understanding of MRI data in living subjects through scans of post-mortem brains in combination with light and electron microscopy in the same tissue. Finally, using ultra-high-field MRI scanners and sophisticated signal processing methods, we are developing the next generation of diffusion and functional MRI acquisition techniques, specifically aimed at measures of brain connectivity.

These methods will enable neuroscientists to study the brain with greater precision. My group is actively involved in collaborations with neuroscience colleagues in Oxford and elsewhere to study neuronal health and disease.