'Therapeutic potential of IL-18 targeting therapies in IBD - from computational biology and functional understanding towards a clinical trial.'
PI: Holm Uhlig, Paul Klenerman, Arian Laurence
'Inhibition of alpha-synuclein aggregation and glial activation as a therapeutic strategy for Parkinson’s disease'
PI: Richard Wade-Martins
'A computational framework for T cell trafficking and dynamics in anti-tumour immune responses'
PI: Mark Coles, Eamonn Gaffney
'Studying the effects of citrullination on the dynamics of receptor-ligand pair interactions at the Immune Synapse'
PI: PI: Michael Dustin
'Investigation of epigenetic and post-translational modifications in altered STAT3'
PI: Professor Holm Uhlig & Dr. Arian Laurence
'Protein kinase C-θ and PD-1 as a therapeutic target in inflammatory arthritis'
PI: Graham Ogg, Peter Taylor, Mike Dustin
'Combination therapy of low dose regulatory T cells and low dose IL-2 to prevent rejection in transplantation'
PI: Dr Joanna Hester & Dr Fadi Issa
'Targeting intracellular trafficking and nucleocytoplasmic transport in mouse and human motor neurons carrying ALS mutations in TDP-43'
PI: Kevin Talbot
'Ultra low-dose IL-2 therapy in autoimmune diabetes'
PI: John Todd, Claudia Monaco
'Investigation of T cell reactivity to alpha-synuclein in Parkinson's disease'
'Targeting Epigenetic Mechanisms for the Treatment of Pancreatic Neuroendocrine Tumours'
PI: Rajesh Thakker
'Unravelling the role of E2F-1 citrullination in inflammatory disease'
PI: Nicholas la Thangue
'Single-cell characterisation of tumour-infiltrating immune cells in pancreatic cancer to uncover therapeutic vulnerabilities.'
PIs: Mark Middleton, Michael Dustin
'Single cell computational biology for translational medicine.'
PIs: Paresh Vyas, Adam Mead, Claus Nerlov
'Defining an early signature of neutrophil extracellular trap formation predictive of responses to PAD4/2 inhibitors in rheumatic patients.'
PI: Irina Udalova, Raashid Luqmani
'Identification of novel therapeutic targets and disease biomarkers in human liver fibrosis by dissecting cellular heterogeneity'
PI: Jagdeep Nanchahal
'Target safety and efficacy evaluation in chronic heart failure using human-based modelling and simulation.'
PI: Blanca Rodriguez