Past BMS-Fellows

'Therapeutic potential of IL-18 targeting therapies in IBD - from computational biology and functional understanding towards a clinical trial.'

PI: Holm Uhlig, Paul Klenerman, Arian Laurence

'Inhibition of alpha-synuclein aggregation and glial activation as a therapeutic strategy for Parkinson’s disease'

PI: Richard Wade-Martins

'A computational framework for T cell trafficking and dynamics in anti-tumour immune responses'

 PI: Mark Coles, Eamonn Gaffney

'Studying the effects of citrullination on the dynamics of receptor-ligand pair interactions at the Immune Synapse'

PI: Michael Dustin

'Definition of new drug targets for fibrosis in Crohns'

PI: Alison Simmons

'Investigation of epigenetic and post-translational modifications in altered STAT3'

PI: Professor Holm Uhlig & Dr. Arian Laurence

'Protein kinase C-θ and PD-1 as a therapeutic target in inflammatory arthritis'

PI: Graham Ogg, Peter Taylor, Mike Dustin

'Combination therapy of low dose regulatory T cells and low dose IL-2 to prevent rejection in transplantation'

PI: Dr Joanna Hester & Dr Fadi Issa

'Targeting intracellular trafficking and nucleocytoplasmic transport in mouse and human motor neurons carrying ALS mutations in TDP-43'

 PI: Kevin Talbot

'Ultra low-dose IL-2 therapy in autoimmune diabetes'

PI: John Todd, Claudia Monaco

'Use of unbiased T-cell receptor repertoire sequencing to identify novel T-cell subsets involved in coeliac disease and increase the accuracy of the diagnosis of gluten sensitivity'

PI: Elizabeth Soilleux, Paul Klennerman

'Therapeutic potential of IL-18 targeting therapies in IBD - from computational biology and functional understanding towards a clinical trial'

PI: Holm Uhlig

'Determining changes in clonal/sub clonal architecture and relation to immune marrow environment enabling tumour persistence/relapse in myeloma'

PI: Paresh Vyas, Udo Oppermann, Karthik Ramasamy

'Investigation of T cell reactivity to alpha-synuclein in Parkinson's disease'

PI: Richard Wade-Martins

'Using cell-matrix ecosystems to define disease progression and treatment response in fibrosis'

PI: Kim Midwood

'Frozen shoulder: A human disease model of resolving inflammatory fibrosis'

PI: Stephanie Dakin

'Defining an early signature of neutrophil extracellular trap formative predictive of responses to PAD4/2 inhibitors in rheumatic patients'

PI: Irina Udalova, Raashid Luqman

'Single cell analysis of the fibrotic landscape in Dupuytren's Disease'

PI: Jagdeep Nanchahal

'Targeting Epigenetic Mechanisms for the Treatment of Pancreatic Neuroendocrine Tumours'

PI: Rajesh Thakker

'Single-cell analysis of autoreactive B cells'

PI: Lynn Dustin

'Exploring Polycomb repressive complex as therapeutic targets in high-risk multiple myeloma patient subsets'

PI: Udo Opperman

'Unravelling the role of E2F-1 citrullination in inflammatory disease'

PI: Nick La Thangue

'Clonal and Functional heterogeneity in AG221-treated IDH2 mutant Acute Myeloid Leukaemia'

PI: Paresh Vyas

'Checkpoint blockade-mediated autoimmune colitis as a model for gut immune homeostasis'

 PI: Paul Klenerman, Oliver Brain

'Unravelling the role of E2F-1 citrullination in inflammatory disease'

PI: Nicholas la Thangue

'Single-cell characterisation of tumour-infiltrating immune cells in pancreatic cancer to uncover therapeutic vulnerabilities.'

PIs: Mark Middleton, Michael Dustin

'Harnessing the Graft-versus-Leukaemia Effect in Acute Myeloid Leukaemia'

PIs: Paresh Vyas, Persephone Borrow

'Single cell computational biology for translational medicine.'

PIs: Paresh Vyas, Adam Mead, Claus Nerlov

'Defining an early signature of neutrophil extracellular trap formation predictive of responses to PAD4/2 inhibitors in rheumatic patients.'

PI: Irina Udalova, Raashid Luqmani

'Novel biomarkers of cardiopulmonary function in heart failure with preserved ejection fraction using exercise magnetic resonance'

PI: Andrew Lewis