Genomic Medicine and Statistics
Warren Kretzschmar (2011 - 2016)
After studying biochemistry at Beloit College, WI, USA, and post-baccalaureate research at the National Human Genome Research Institute, MD, USA, Warren obtained a Master in Applied Statistics at the University of Oxford, UK. Subsequently, he joined the Genomic Medicine and Statistics program in 2011. Under the supervision of Jonathan Marchini, Warren's DPhil work focused on the development of statistical methods to call genotypes from very large sets of low coverage sequencing data. For the CONVERGE consortium, he wrote the pipeline to create analysis-ready genotypes that were used to discover the first replicated genome-wide association hit for major depression. Warren also developed a statistical method to call the genotypes for the Haplotype Reference Consortium. After submitting his thesis, he will be joining a startup in San Francisco.
Matthias Thurner (2012 -Present)
Matthias is from Austria and came to the UK to obtain a BSc in Biological Sciences at UCL in 2009. He graduated with a first class degree in 2012 and received an offer from the Wellcome Trust Genomic Medicine and Statistics DPhil programme at the University of Oxford. In the first year the programme provided Matthias with the opportunity to conduct both wet and dry lab research as part of two rotational research projects: The first project focussed on analysing mutations of the tumour suppressor protein FBXW7 in colorectal and endometrial cancer using wet lab techniques. During the second rotation he developed computational methods for identifying exonic deletions using exome chip arrays and testing these deletions for their contribution to the development of Type 2 Diabetes (T2D). For his DPhil Matthias decided to work with Prof Mark McCarthy and Prof Anna Gloyn to determine the role of novel genetic (exonic Copy number variants) and epigenetic (DNA methylation and open chromatin modifications) mechanisms in the role of the development of T2D.
Marieke Oudelaar (2014 - present)
Marieke completed her undergraduate studies in Utrecht (the Netherlands) and obtained a Master’s degree in Biomedicine at the Karolinska Institute in Stockholm (Sweden). In 2014 she joined the Wellcome Trust programme in Genomic Medicine and Statistics. After a wet-lab rotation in Doug Higgs’ lab and a dry-lab rotation in Jim Hughes’ lab in her first year, she started her DPhil project under co-supervision of Jim and Doug, combining both experimental and computational approaches. In her DPhil project she studies the structure of the genome and its role in gene regulation, using the well characterised alpha-globin locus in different stages of erythroid differentiation as a model. She is particularly interested in the interplay between 3-D genome structure and the action of distal regulatory elements to modulate gene expression.