Yin Dong studied biochemistry at the University of Warwich for his undergraduate degree, before undertaking a PhD at the University of Birmginham under the supervision of Prof Karen Morrison. He then worked at the Structural Genomics Consortium as a post-doctoral research associate with Prof Liz Carpenter. He won a MRC Career Development Fellowship to start his independent research at the Nuffield Department of Clinical Neurosciences under the mentorship of Prof David Beeson, working in the Weatherall Institute of Molecular Medicine.
Yin Yao Dong
University Research Lecturer
MRC Career Development Fellow
- Head of Neurosciences Group at the WIMM
- Manager of functional diagnostics for the National Referral Service for Congenital Myasthenic Syndromes.
Diseases of the neuromuscular junction and N-glycosylation
N-glycosylation is one of the most common forms of post-translational modification, and is present on most membrane and secreted proteins. It is essential to all eukaryotic life, yet we know little about the function of the vast majority of N-linked glycans. Mutations that lead to abnormalities in N-glycosylation can lead to the devastating multisystem disorder Congenital Diseases of Glycosylation (CDG) or the milder Congenital Myasthenic Syndromes (CMS), where patients mainly suffer from dysfunctional neuromuscular junctions.
The focus of my group's research is to better understand the process of N-glycosylation, and why abnormalities in this ubiquitous process can lead to the specific dysfunction in neuromuscular junctions. To achieve this, we use a multidisciplined approach combining techniques in biochemistry, structural biology, molecular biology and glycomics.