Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

J. Ross Chapman


Associate Professor, CRUK CDF, Lister Fellow & EMBO Young Investigator

Genome stability and DNA repair mechanisms in cancer and genome diversification

The accurate repair of DNA breaks is fundamental for protecting our genomes against cancer-causing mutations, however, the B and T lymphocytes of our immune systems deliberately induce and repair DNA breaks in a mutagenic fashion in order to adapt and diversify antigen receptor molecules. My group is interested in how cells and different tissues strike an appropriate equilibrium between accurate and mutagenic DNA repair mechanisms, so that we can understand why faults in this regulation lead to cancer, and devise innovative strategies to exploit these faults in cancer therapies.


Direct Entry Research Degrees