Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A new study led by Radcliffe Department of Medicine researchers analyses iron levels in COVID-19 intensive care patients to find that patients with very low levels of iron had severe respiratory failure.

The study, published in the journal Critical Care, is part of an ongoing close collaboration between ICU academic clinicians Dr Akshay Shah and Dr Stuart McKechnie, and Professor Hal Drakesmith’s research group at the MRC Weatherall Institute of Molecular Medicine.

Changes in iron levels have been associated with worsening disease for other viral infections such as HIV and Hepatitis C, but this is the first study to find a similar link for COVID-19.

Iron is essential for the growth of pathogens, but also for the body’s own immune response. So during an infection, the immune system ‘sequesters’ iron to deprive pathogens. At the same time, the immune system’s T and B lymphocytes (white blood cells that are a key art of the body’s immune response) need iron to clear the infection.

Read more on the Radcliffe Department of Medicine website

Similar stories

Human challenge trial launches to study immune response to COVID-19

Clinical Trials Coronavirus COVID-19 General

Though the COVID-19 pandemic has now been active for a year, not much is known about what happens when people who have already had COVID-19 are infected for a second time.

Risk of rare blood clotting higher for COVID-19 than for vaccines

Coronavirus COVID-19 Research

COVID-19 leads to a several-times higher risk of cerebral venous thrombosis (CVT) blood clots than current COVID-19 vaccines.

Alternating vaccines trial expands to include two additional vaccines

Clinical Trials Coronavirus COVID-19 General

Researchers running the Com-Cov study, launched in February to investigate alternating doses of the Oxford-AstraZeneca vaccine and the Pfizer vaccine, have today announced that the programme will be extended to include the Moderna and Novavax vaccines in a new study.

Oxford medical students launch flagship raffle in aid of NHS heroes and lifesaving medical equipment

General

Tingewick, a society formed of medical students from Oxford University, are hosting a virtual charity raffle. With over 70 amazing prizes, ranging from Truck festival tickets to restaurant vouchers to bags of books and even a bike, the raffle is an exciting way to celebrate lockdown lifting by supporting many wonderful Oxfordshire businesses whilst raising lots of money for charity.

Asthma drug budesonide shortens recovery time in non-hospitalised patients with COVID-19

Clinical Trials Coronavirus COVID-19 Research

Inhaled budesonide, a common corticosteroid, is the first widely available, inexpensive drug found to shorten recovery times in COVID-19 patients aged over 50 who are treated at home and in other community settings, reports the PRINCIPLE trial in 1,779 participants.