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Jakob Theorell, Ruby Harrison et al
The research, ‘Ultrahigh frequencies of peripherally matured LGI1 & CASPR2-reactive B cells characterise encephalitis patient cerebrospinal fluid’, published in Proceedings of the National Academy of Sciences PNAS, sheds new light on the molecular mechanisms behind autoimmune encephalitis (AE) – a rare but serious neurological condition.
Led by Professor Sarosh Irani, the study brought together researchers across disciplines to investigate the properties of antibodies that cause AE. The team analysed over 150 antibodies isolated from the cerebrospinal fluid (CSF) of affected patients and discovered that, remarkably, around 80% were reactive to just two self-proteins: LGI1 and CASPR2.
Other NDCN co-authors included: Jakob Theorell, Ruby Harrison, Robyn Williams, Meng Zhao, Hannah Fox, Andrew Fower, Georgina Miller, Zoe Wu, Eleanor Browne, Bo Sun, Patrick Waters, Adam Handel and Mateusz Makuch.
Read the full story on the Nuffield Department of Clinical Neurosciences website.