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Researchers develop new regimen to block transmission of malaria in sub-Saharan Africa

Primaquine can be used to prevent the transmission of falciparum malaria from human to mosquito. Bob Taylor and colleagues at the Mahidol Oxford Research Unit (MORU) have developed an age-based regimen for single low-dose primaquine to block the transmission of malaria in sub-Saharan Africa.

Black female seated on a carpet in a house made of hemp or similar

Image courtesy of Speak Up Africa

The World Health Organization (WHO) recommended in 2012 to add single low-dose primaquine (SLDPQ) to standard artemisinin based combination treatments (ACTs) to block the transmission of Plasmodium falciparum malaria. The target dose of 0.25 mg base/kg body weight (15 mg in a 60 kg adult) was considered safe in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDd) and SLDPQ was recommended to be given without testing for G6PDd.

Find out more (Worldwide Antimalarial Resistance Network website)

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