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Oxford Pain: Key Publications

Key recent publications from across the cluster

  • Middleton SJ, Markússon S, Åkerlund M, Deme JC, Tseng M, Li W, Zuberi SR, Kuteyi G, Sarkies P, ..... Bennett DL, SLC45A4 is a pain gene encoding a neuronal polyamine transporter. 2025. Nature. In Press. 

  • Farah A, Daifallah O, Singh E, Dawes JM. Autoantibodies as drivers of neuropathic pain. Trends Mol Med. 2025 Jul 30:S1471-4914(25)00169-8. doi: 10.1016/j.molmed.2025.07.003. Epub ahead of print. PMID: 40744832.
  • Farah A, Patel R, Poplawski P, Wastie BJ, Tseng M, Barry AM, Daifallah O, Dubb A, Paul I, Cheng HL, Feroz F, Su Y, Chan M, Zeilhofer HU, Price TJ, Bennett DL, Bannister K, Dawes JM. A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity. Brain. 2025 Mar 6;148(3):1001-1014. doi: 10.1093/brain/awae302. PMID: 39301592; PMCID: PMC11884686.

  • Mancini, F., Mahajan, P., Guttesen, A.Á.V., Onysk, J., Scholtes, I., Shenker, N., Lee, M. and Seymour, B., 2025. Enhanced behavioural and neural sensitivity to punishments in chronic pain and fatigue. Brain, 148(6), pp.2151-2162.

  • Kelleher, E.M., Lange, F., Wanigasekera, V., Rathod-Mistry, T., Nichols, T., Seymour, B., Tracey, I., Segerdahl, A.R. and Irani, A., 2025. Brain signatures of nociplastic pain: Fibromyalgia Index and descending modulation at population level. Brain, p.awaf307.

  • Kelleher, E., Kaplan, C.M., Kheirabadi, D., Schrepf, A., Tracey, I., Clauw, D.J. and Irani, A., 2025. The number of central nervous system-driven symptoms predicts subsequent chronic primary pain: evidence from UK Biobank. British Journal of Anaesthesia, 134(3), pp.772-782.

  • Wang, S., Barry, A.M., Lee, Y.K., Young, N., Shim, S.W., Wang, X., Kim, H., Stirling-Barros, L., González-Cano, R., Costigan, M. and Baskozos, G., 2025. NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons. bioRxiv, pp.2025-07.
  • Sandy-Hindmarch, O.P., Chang, P.S., Scheuren, P.S., De Schoenmacker, I., Hubli, M., Loizou, C., Wirth, S., Mahadevan, D., Wiberg, A., Furniss, D. and Calvo, M., 2025. The local molecular signature of human peripheral neuropathic pain. Pain, 166(5), pp.1143-1156.
  • T.A.Perry, Y.Deng, P.Hulley, R.A.Maciewicz, J.Mitchelmore, S.Larsson, J.Gogain, S.Brachat, A.Struglics, ......T.L.Vincent*. *co-senior authors. Deconvoluting synovial fluid molecular endotypes in knee osteoarthritis: primary results from the STEpUP OA Consortium. Nature Communications in press 2025. MedRxiv preprint: https://www.medrxiv.org/content/10.1101/2024.06.05.24308485v1
  • Hauck, A.G., van der Vaart, M., Adams, E., Baxter, L., Bhatt, A., Crankshaw, D., Dhami, A., Fry, R.E., Freire, M.B., Hartley, C. and Mansfield, R.C., 2024. Effect of parental touch on relieving acute procedural pain in neonates and parental anxiety (Petal): a multicentre, randomised controlled trial in the UK. The Lancet Child & Adolescent Health, 8(4), pp.259-269.
  • Katayama, R., Shiraki, R., Ishii, S. and Yoshida, W., 2024. Belief inference for hierarchical hidden states in spatial navigation. Communications Biology, 7(1), p.614.
  • Spinal cord stimulation improves quality of life for patients with chronic neuropathic pain – data from the British National Neuromodulation Registry. Martin SC, Baranidharan G, Thomson S, Gulve A, Manfield J, Mehta V, Love-Jones S, Strachan R, Bojanic S, Eldabe S, FitzGerald JJ. Neuromodulation 2024;27(8):1406-1418.
  • Kaplan, C.M., Kelleher, E., Irani, A., Schrepf, A., Clauw, D.J. and Harte, S.E., 2024. Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms. Nature Reviews Neurology, 20(6), pp.347-363.
  • Brinkman, N., Thomas, J.E., Teunis, T., Ring, D., Gwilym, S. and Jayakumar, P., 2024. Recovery of comfort and capability after upper extremity fracture is predominantly associated with mindset: a longitudinal cohort from the United Kingdom. Journal of Orthopaedic Trauma, 38(10), pp.557-565.
  • Harlow, C. E., Uzochukwu, E., Fernando, H. A., Mordaunt, C. E., Hughey, J. M., Eicher, J. D., ... & Cader, M. Z. (2024). GWAS of Extended Prescription Analgesic Use Identifies Novel Genetic Loci in Chronic Pain. medRxiv, 2024-12.
  • Chapman, T.P., Zand, A.P.D., Debrah, E., Petric, B., Farrell, S.M., FitzGerald, J.J., Moosavi, S.H. and Green, A.L., 2024. Deep brain stimulation of the motor thalamus relieves experimentally induced air hunger. European Respiratory Journal, 64(6).
  • Developing RPC-Net: leveraging high-density electromyography and machine learning for improved hand position estimation. Rolandino G, Gagliardi M, Martins T, Cerone GL, Andrews B, FitzGerald JJ. IEEE Trans Biomed Eng 2023;99:1-11.
  • Kim, H.W., Shim, S.W., Zhao, A.M., Roh, D., Han, H.M., Middleton, S.J., Kim, W., Chung, S., Johnson, E., Prentice, J. and Tacon, M., 2023. Long-term tactile hypersensitivity after nerve crush injury in mice is characterized by the persistence of intact sensory axons. Pain, 164(10), pp.2327-2342.
  • Themistocleous, A.C., Baskozos, G., Blesneac, I., Comini, M., Megy, K., Chong, S., Deevi, S.V., Ginsberg, L., Gosal, D., Hadden, R.D. and Horvath, R., 2023. Investigating genotype–phenotype relationship of extreme neuropathic pain disorders in a UK national cohort. Brain Communications, 5(2), p.fcad037.
  • Kim HW, Wang S, Oh SB* and Davies AJ*, The therapeutic potential of natural killer cells in neuropathic pain. Trends Neuroscience 2023;46(8):617-627. DOI: 10.1016/j.tins.2023.05.008.
  • Wiberg A, Lucey MA, Kleeman S, Kang Y, Ng M, Furniss D. Genetic Correlations between Migraine and Carpal Tunnel Syndrome. Plast Reconstr Surg. 2024 Jul 1;154(1):126e-134e. doi: 10.1097/PRS.0000000000010976. Epub 2023 Aug 18. PMID: 37606917; PMCID: PMC11195923.
  • Barry, A.M., Zhao, N., Yang, X., Bennett, D.L. and Baskozos, G., 2023. Deep RNA-seq of male and female murine sensory neuron subtypes after nerve injury. Pain, 164(10), pp.2196-2215.
  • Kang, Y., Trewern, L., Jackman, J., McCartney, D. and Soni, A., 2023. Chronic pain: definitions and diagnosis. Bmj, 381.
  • Perez-Sanchez, J., Middleton, S.J., Pattison, L.A., Hilton, H., Ali Awadelkareem, M., Zuberi, S.R., Renke, M.B., Hu, H., Yang, X., Clark, A.J. and St. John Smith, E., 2023. A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons. Science translational medicine, 15(716), p.eadh3839.
  • Patel B, Kleeman SO, Neavin D, Powell J, Baskozos G, Ng M, Ahmed WU, Bennett DL, Schmid AB, Furniss D, Wiberg A. Shared genetic susceptibility between trigger finger and carpal tunnel syndrome: a genome-wide association study. Lancet Rheumatol. 2022 Aug;4(8):e556-e565. doi: 10.1016/S2665-9913(22)00180-1. PMID: 36043126; PMCID: PMC7613465.
  • Non-invasive phrenic nerve stimulation to avoid ventilator induced diaphragm deconditioning in critical care. Keogh C, Saavedra F, Dubo S, Aqueveque P, Ortega P, Gomez B, Germany E, Pinto D, Osorio R, Pastene F, PoultonA, Jarvis J, Andrews B, FitzGerald JJ. Artif Organs. 2022;46(10):1988-1997.
  • Åkerlund, M., Baskozos, G., Li, W., Themistocleous, A.C., Pascal, M.M., Rayner, N.W., Attal, N., Baron, R., Baudic, S., Bennedsgaard, K. and Bouhassira, D., 2022. Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort. Pain, pp.10-1097.
  • Trendafilova, T., Adhikari, K., Schmid, A.B., Patel, R., Polgár, E., Chisholm, K.I., Middleton, S.J., Boyle, K., Dickie, A.C., Semizoglou, E. and Perez-Sanchez, J., 2022. Sodium-calcium exchanger-3 regulates pain “wind-up”: From human psychophysics to spinal mechanisms. Neuron, 110(16), pp.2571-2587.
  • Themistocleous, A.C., Kristensen, A.G., Sola, R., Gylfadottir, S.S., Bennedsgaard, K., Itani, M., Krøigård, T., Ventzel, L., Sindrup, S.H., Jensen, T.S. and Bostock, H., 2022. Axonal excitability does not differ between painful and painless diabetic or chemotherapy‐induced distal symmetrical polyneuropathy in a multicenter observational study. Annals of Neurology, 91(4), pp.506-520.
  • Katayama, R., Yoshida, W. & Ishii, S. Confidence modulates the decodability of scene prediction during partially-observable maze exploration in humans. Commun Biol 5, 367 (2022).
  • Mancini, F., Zhang, S. and Seymour, B., 2022. Computational and neural mechanisms of statistical pain learning. Nature Communications, 13(1), p.6613.
  • Baskozos, G., Themistocleous, A.C., Hebert, H.L., Pascal, M.M., John, J., Callaghan, B.C., Laycock, H., Granovsky, Y., Crombez, G., Yarnitsky, D. and Rice, A.S., 2022. Classification of painful or painless diabetic peripheral neuropathy and identification of the most powerful predictors using machine learning models in large cross-sectional cohorts. BMC medical informatics and decision making, 22(1), p.144.
  • L. Wei, Y. Wu, F. Zirpel, G. Flower, J. V Vierbergen, V. Wieser, S. Peirson, H. Sleven, A. Pokhilko, M. Z. Cader (2022). Cryptochrome Stabilization Ameliorates Chronic Pain, bioRxiv 2022.07.15.499708;
  • Gwilym, S.E., Perry, D.C. and Costa, M.L., 2021. Trauma and orthopaedic research is being driven by priorities identified by patients, surgeons, and other key stakeholders. The Bone & Joint Journal, 103(8), pp.1328-1330.
  • Raghu ALB, Eraifej J, Sarangmat N, Stein J, FitzGerald JJ, Payne S, Aziz TZ, Green AL. Pallido-putaminal connectivity in predicts outcomes of deep brain stimulation for cervical dystonia. Brain 2021 144(12):3589-3596. doi: 10.1093/brain/awab280.
  • Cobo, M.M., Hartley, C., Gursul, D., Andritsou, F., van der Vaart, M., Mellado, G.S., Baxter, L., Duff, E.P., Buckle, M., Fry, R.E. and Green, G., 2021. Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials. eLife, 10, p.e65266.
  • Shah RF, Gwilym SE, Lamb S, Williams M, Ring D, Jayakumar P. Factors associated with persistent opioid use after an upper extremity fracture. Bone Jt Open. 2021;2(2):119-124. doi:10.1302/2633-1462.22.BJO-2020-0167.R1
  • Pokhilko, A., Nash, A., & Cader, M. Z. (2020). Common transcriptional signatures of neuropathic pain. Pain, 161(7), 1542-1554.
  • Zhang, S., Yoshida, W., Mano, H., Yanagisawa, T., Mancini, F., Shibata, K., Kawato, M. and Seymour, B., 2020. Pain control by co-adaptive learning in a brain-machine interface. Current Biology, 30(20), pp.3935-3944.
  • Isabell S von Loga, V Batchelor, C Driscoll, A Burleigh, S-L Chia, B Stott, J Miotla-Zarebska, D Riley, F Dell’Accio, Tonia L Vincent (2020). Does pain at earlier stage of chondropathy protect female mice from structural damage after joint destabilisation? Arthritis and Rheumatology, 72(12), 2083-2093. doi:10.1002/art.41421
  • Turro, E., Astle, W.J., Megy, K., Gräf, S., Greene, D., Shamardina, O., Allen, H.L., Sanchis-Juan, A., Frontini, M., Thys, C. and Stephens, J., 2020. Whole-genome sequencing of patients with rare diseases in a national health system. Nature, 583(7814), pp.96-102.
  • Zhang, S., Yoshida, W., Mano, H., Yanagisawa, T., Mancini, F., Shibata, K., Kawato, M. and Seymour, B., 2020. Pain control by co-adaptive learning in a brain-machine interface. Current Biology, 30(20), pp.3935-3944.
  • Duff, E.P., Moultrie, F., van der Vaart, M., Goksan, S., Abos, A., Fitzgibbon, S.P., Baxter, L., Wager, T.D. and Slater, R., 2020. Inferring pain experience in infants using quantitative whole-brain functional MRI signatures: a cross-sectional, observational study. The Lancet Digital Health, 2(9), pp.e458-e467.
  • Isabell S von Loga, Aadil El-Turabi, Jadwiga Zarebska, Andris Zeltins, Ida Parisi, Martin F Bachmann, Tonia L Vincent. Active immunisation Targeting Nerve Growth Factor Attenuates Chronic Pain in Murine Osteoarthritis. Ann Rheum Dis 2019;0:1–4.
  • Wiberg A, Ng M, Schmid AB, Smillie RW, Baskozos G, Holmes MV, Künnapuu K, Mägi R, Bennett DL, Furniss D. A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nat Commun. 2019 Mar 4;10(1):1030. doi: 10.1038/s41467-019-08993-6. PMID: 30833571; PMCID: PMC6399342.
  • Davies AJ, Kim HW, Gonzalez-Cano R, Choi J, Back SK, Roh SE, Johnson E, Gabriac M, Kim MS,...., and Oh SB, Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell 2019;176(4):716-728 e18. DOI: 10.1016/j.cell.2018.12.022.
  • Dawes JM, Weir GA, Middleton SJ, et al. Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability. Neuron. 2018;97(4):806-822.e10. doi:10.1016/j.neuron.2018.01.033
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