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LOCATION

Oxford Transplant Centre, Churchill Hospital, Oxford, OX3 7LE

Simon Knight

MA MChir FRCS


Associate Professor of Transplant Surgery

  • Honorary Consultant Transplant and Vascular Access Surgeon
  • Director, Centre for Evidence in Transplantation
  • Divisional Medical Informatics Lead for SUWON division
  • Clinical Lead for Vascular Access Surgery

I undertook my undergraduate studies at Corpus Christi College, Cambridge, gaining a BA in medical science in 2000 before studying clinical medicine at Addenbrooke's Hospital, Cambridge. I qualified as a doctor in 2002, and moved to Nottingham for my Basic Surgical Training. I moved to Oxford in May 2006 to take up a position with the Centre for Evidence in Transplantation (CET) as a clinical research fellow in transplant surgery, during which time I completed my Master of Surgery (MChir) thesis with the University of Cambridge. After completion of my surgical training, I took up a post as an Honorary Consultant Transplant Surgeon and Senior Clinical Research Fellow at Oxford in 2017. I have now taken over as Director of the CET.

My research interests lie in evidence-based transplant surgery, transplant clinical trials, trial methodology and health informatics.

I have completed and supervised a large number systematic reviews relating to the optimisation of post-transplant immunosuppression and other topics in transplantation.  The CET has worked closely with the European Society for Organ Transplantation and British Transplantation Society, providing input into clinical practice guidelines, consensus statements and trial design for members.

I am co-PI and investigator for a number of national and international clinical trials. I was part of the design committee for of the Consortium for Organ Preservation in Europe (COPE) trials of novel organ preservation techniques, all three of which are now complete and published. I am co-PI for the NIHR-funded PLUS, COBALT and DeFAT studies, and co-applicant for the NIHR-funded NKP-1, SONAR and TAR-GET 1 studies.  I am a member of the BTS Organ Donation and Transplant Research Network Board and and associate editor for European Surgical Research.

I also have an interest in health informatics and clinical decision support tools. In my clinical role, I am Divisional Medical Informatics Lead for Surgery Women's and Oncology Division (SUWON). I am currently working with the AI for Digital Heath lab, investigating the use of machine learning models in aiding clinical decision making around organ offers. This work is funded by an NIHR AI in Health and Care award.

For more information on my work, and that of the CET, please visit the CET website.

 

Key publications

A randomized trial of normothermic preservation in liver transplantation

Journal article

Nasralla D. et al, (2018), Nature, 557, 50 - 56

Quality and consistency of outcome reporting in clinical trials of immunosuppression in renal transplantation

Journal article

Hussain S. and Knight SR., (2016), Clinical Transplantation, 30, 1440 - 1448

Trial design and endpoints in clinical transplant research

Journal article

Knight SR. et al, (2016), Transplant International, 29, 870 - 879

Recent publications

Acceptance of deceased donor livers in the United Kingdom - development of a liver "donor utilisation index"

Journal article

Mehew J. et al, (2026), Transplant International Official Journal of the European Society for Organ Transplantation, 39