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Christopher Toepfer
PhD
Associate Professor of Cardiovascular Science
- Sir Henry Dale Fellow, Wellcome
- BHF CRE Intermediate Transition Fellow 2019-2021
- Eugene Braunwald Fellowship in Cardiovascular Medicine 2018-2019 BWH
Inherited Cardiomyopathies and Human Model Systems
Background
Chris completed his PhD at Imperial College London under the supervision of Professor Michael Ferenczi and Dr. James Sellers (NHLBI, NIH). Studying cardiac muscle regulation in health and disease. He subsequently began a Post-doc with the support of a Sir Henry Wellcome Post-Doctoral Fellowship with Professors Christine and Jonathan Seidman at Harvard Medical School and Professor Hugh Watkins at the RDM Oxford.
Chris is currently supported by a Sir Henry Dale Fellowship from Wellcome. The laboratory focuses on CRISPR/Cas-9 engineering and the use of human model systems such as iPSC-CMs, engineered heart tissues, and organoids. Chris's team use these model human heart disease in a dish systems to uncover new mechanisms in inherited and acquired heart diseases.
In the Press and Editorials
- BBC website 'Cancer treatment broke my heart, but I've survived'
- Nature Reviews Cardiology Editorial ‘Modulating myosin function to treat hypertrophic cardiomyopathy’
- Circulation Editorial ‘Manipulating Myosin May Help Treat Hypertrophic Cardiomyopathy’
- Circulation Research Editorial ‘High-Throughput Contractility Assay for Human Stem Cell-Derived Cardiomyocytes: One Beat Closer to Tracking Heart Muscle Dynamics’
- HMS press release and interview ‘On the Beat’
- HMS press release and interview ‘Bad Brakes’
- HMS press release and interview 'Revving the engine'