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Oxford-MRC DTP iCASE 2025 Projects

MRC ENTERPRISE STUDENTSHIP PROGRAMME 2025 (INDUSTRIAL CASE AWARDS)

Eight industrial CASE (iCASE) studentships are available for doctoral study at Oxford, to start in October 2025. 

Designed to nurture the academic entrepreneurs of the future, the Enterprise studentship programme offers a stimulating educational experience as part of the Oxford-MRC DTP cohort, with the additional benefit of working closely with an industrial partner. This will provide entrepreneurial training opportunities and an insight into how commercial science is conducted alongside a superb academic base within the University. Students will work for at least 3 months in the associated company.

ELIGIBILITY

They are open to both UK and non-UK nationals and will follow the UKRI student eligibility requirements. UKRI will normally limit the proportion of international students appointed each year through individual training grants to 30% of the total intake each year.

FUNDING PACKAGE

Each iCASE studentship is fully-funded - it includes four years of stipend at the UKRI stipend level + £2,500 p.a., course fees (including overseas fees if applicable), and a generous research training support grant.

 

APPLICATIONS DEADLINE

Applications must be received by 12 noon (UK time) Tuesday 3 December 2024. Details on entry requirements and  how to apply can be found below.

 

PROJECTS

The projects available are:

 

1. Developing new antifungal drugs by targeting glycosylation pathways using a structural biology approach

Lead supervisor:  Prof. Simon Newstead

Commercial partner: Iceni Glycoscience 

 

2. Developing hardware and software to improve Magnetic Resonance Neuroimaging

Lead supervisor: Dr James Grist

Commercial partner: GE Healthcare

 

3. Understanding the effects of combined immune checkpoint inhibition through space and time

Lead supervisor: Prof. David Withers

Commercial partner: AstraZeneca

 

4. Combating memory decline during sleep

Lead supervisor:  Prof. Bernhard Staresina

Commercial partner: Clarity Technologies

 

5. Developing a Comprehensive Framework for Clinical Validation of Generative AI in Primary Care: Beyond Performance Metrics 

Lead supervisor:  Dr Catia Nicodemo

Commercial partner: EMIS

 

6. Hunting for injured nerves: Discovering diagnostic and therapeutic biomarkers for painful nerve injury using targeted binding domain libraries from the shark immune system

Lead supervisor:  Dr Alexander Davies

Commercial partner: Elasmogen Limited

 

7. Immunogenic response to anti-TNF therapeutics: defining the role of protein glycosylation

Lead supervisor: Prof. Jack Satsangi

Commercial partner: Ludger Ltd

 

8. Advancing diagnostics for precision medicine in severe infection

Lead supervisor:  Prof. Julian Knight

Commercial partner: Danaher

 

9. The mechanisms of control of the TMEM16A channel by the lysosomal NPC1 protein: a new role for the lysosome in the control of cell excitability

Lead supervisors:  Prof. Paolo Tammaro and Prof. Fran Platt

Commercial partner: Autifony Therapeutics

 

10. Neuropeptide regulation of gastric motility as a comorbidity and diagnostic for endometriosis and pancreatic cancer

Lead supervisor: Prof. Eric O'Neill

Commercial partner: Hertility health

 

11. Defining MR1-ligand expression in human and mouse tissues

Lead supervisor:  Prof. Paul Klenerman

Commercial partner: Immunocore

 

12. Molecular reclassification of the spectrum of Alzheimer’s disease: Multi-omic, multi-modal models for diagnosis, risk stratification and prognosis prediction

Lead supervisor:  Dr Ivan Koychev

Commercial partner: CFDX Ltd 

 

13. Computational statistics and deep learning to strengthen families and reduce violence towards children

Lead supervisor:  Dr Seth Flaxman

Commercial partner: IDEMS International Community Interest Company: Innovations in Development, Education and the Mathematical Sciences

 

14. Linking physio-chemical properties of adjuvants to immunological responses for the rational design of next generation vaccines

Lead supervisor:  Prof. Anita Milicic

Commercial partner: iuvantium

 

15. Optimising digitally augmented psychological therapies for children and young people through analysis of routinely captured data

Lead supervisor:  Prof. Cathy Creswell

Commercial partner: Koa Health

 

16. Strategies for novel cardiomyopathy treatments from organoids-informed computational multiscale modelling and simulation

Lead supervisor: Prof. Blanca Rodriguez

Commercial partner: AstraZeneca

 

17. Design, synthesis and optimisation of antisense oligonucleotide therapeutics for improved cellular uptake and efficacy

Lead supervisor:  Prof. Matthew Wood

Commercial partner: ATDBio Ltd

 

18. Exploring the TMEM206 proton-gated chloride channel as a new therapeutic target in ischaemic-mediated capillary disfunction 

Lead supervisors:  Prof. Paolo Tammaro, Prof. Phil Biggin and Prof. Ming Lei

Commercial partner: Novo Nordisk Research Centre Oxford (NNRCO)

 

19. An exploration of the Heart - Liver axis: using MRI to understand how and why measurements taken in the liver relate to adverse cardiovascular outcomes

Lead supervisor: Dr Michael Pavlides

Commercial partner: Perspectum Ltd

 

20. Rapid MRI scanning for population-level neuroimaging

Lead supervisor:  Prof. Aaron T. Hess

Commercial partner: Siemens Healthineers

 

21. Improving TMS-EEG acquisition for clinical populations

Lead supervisor:  Prof. Charlotte Stagg

Commercial partner: Welcony (Magstim Company Ltd and MagstimEGI)

 

22. Develop synthetic extracellular matrix for engineering defined 3D human neural tissue 

Lead supervisor: Prof. Hagan Bayley

Commercial partner: PeptiMatrix

 

23. The discovery of robust septin binders to validate their potential as a future drug target

Lead supervisor: Prof. Matthew Fuchter

Commercial partner: Jazz Pharmaceuticals

 

ENTRY REQUIREMENTS

Within equal opportunities principles and legislation, applications will be assessed in the light of an applicant’s ability to meet the following entry requirements:

1. Academic ability

Proven and potential academic achievements

Applicants are normally expected to be predicted or have achieved a first-class or strong upper second-class undergraduate degree with honours (or equivalent international qualifications), as a minimum, in a relevant discipline such as biology, biochemistry, or medicine (other disciplines might also be relevant for projects hosted by MPLS departments). However, entrance is very competitive and most successful applicants have a first-class degree or the equivalent.

A previous master's degree is not required.

No Graduate Record Examination (GRE) or GMAT scores are sought.

Other appropriate indicators will include:

Supporting documents

You will be required to supply supporting documents with your application, including references and an official transcript. See 'How to apply' for instructions on the documents you will need.

Performance at interview

Interviews are normally held as part of the admissions/funding allocation process.

Candidates who are shortlisted are interviewed as part of the admissions process. Shortlisting will be based on the criteria given above. There will be a minimum of three academics on the interview panel. Interviews will be conducted virtually this year. Normally, the interviews will run for 25 minutes in a question and answer format.

Publications

Prior publications are not required, but research experience and a demonstrable interest in the commercialisation of research may be an advantage.

Other qualifications, evidence of excellence and relevant experience

Evidence of a prior interest in the area of research proposed is likely to advantage your application.

2. English language requirement

Applicants whose first language is not English are usually required to provide evidence of proficiency in English at the standard level required by the University.

3. Disability, health conditions and specific learning difficulties

Students are selected for admission without regard to gender, marital or civil partnership status, disability, race, nationality, ethnic origin, religion or belief, sexual orientation, age or social background.

Decisions on admission are based solely on the individual academic merits of each candidate and the application of the entry requirements appropriate to the course.

Further information on how these matters are supported during the admissions process is available in our guidance for applicants with disabilities.

4. Assessors

All recommendations to admit a student involve the judgment of at least two members of academic staff with relevant experience and expertise, and additionally must be approved by the Director of Graduate Studies or Admissions Committee (or equivalent departmental persons or bodies).

Admissions panels or committees will always include at least one member of academic staff who has undertaken appropriate training.

It would be expected that graduate applicants would be familiar with the recent published work of their proposed supervisor.

HOW TO APPLY

Before applying for these positions we recommend you contact the lead supervisors for informal discussions.

To make a formal application, please complete the University’s online application form for the DPhil course specific to the department hosting the iCASE project you are interested in. Please indicate the iCASE project clearly by inserting ‘iCASE’ before the project title and by using the reference code iCASEYou will need to provide a personal statement (500 words max if applying for a project hosted by one of Medical Sciences departments - please note that this limit might be different if a project is hosted by one of MPLS departments in which case follow their requirement) detailing your interest and fit for the studentship. Note that no project proposal is required for the iCASE studentship applications.

If you wish to apply for a combination of iCASE and other projects within the hosting department, this can be done on the same application form (max number of projects you can apply for on one application depends on the department you wish to apply to). If you wish to apply for iCASE projects within different departments, you will have to make separate applications directly through those departments.

If you have any specific queries about the iCASE application process, please email mrc@medsci.ox.ac.uk. General advice on how to pick a graduate advisor (supervisor) and how to choose a scientific problem can be found in these two articles:

All applications must be received by the deadline of 12 noon (UK time) Tuesday 3 December 2024.

We expect to interview shortlisted applicants in January/February and to make funding offers by the end of February.

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