Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

This prestigious Fellowship aims to stimulate new scientific discovery and translation and to facilitate skills transfer between researchers in academia and industry.

Celgene is a global biopharmaceutical company that uses cutting-edge technology and innovative science to discover new medicines for patients. In partnership the Oxford Medical Sciences Division, Celgene has co-developed and provided support for a Translational Research Fellowship Programme. The goals of this scheme are to stimulate new scientific discovery and translation and to facilitate skills transfer between researchers in academia and industry.  

This programme offers fellows an opportunity to gain exposure to the field of commercial drug discovery and development. They will have an assigned company mentor and where appropriate be encouraged to spend some time based in Celgene's laboratories.

Funding will be awarded to Oxford Principal Investigators to support 3 year fellowship projects for early career researchers that demonstrate a clear translational value to the advancement of therapeutics. Three to four awards are made annually.

Fellowship funding may be used to support clinical (Grade E64) or basic research scientists (Grade 7/8) committed to translational science and interested in obtaining experience with drug development in an industrial setting. 

Fellowship applications may include a named fellow, but this is not necessary as the project selection criteria are driven by scientific fit with company science and expertise.  It is expected that a suitable fellowship candidate will be identified by the Principle Investigator within 6 months of notification of successful project selection.

Prospective Principle Investigator applicants should submit their project online via the Internal Research Award Management System (IRAMS) using the standard application form (this form is also available through IRAMS). We request that applicants notify their department administrators of their intention to submit a proposal (information on the fellowship terms for Department administrators and HoDs can be found here) and that applications are signed off by Department Heads.

Proposals will be reviewed by a Joint Steering Committee.

Proposals should be targeted to research areas of interest for Celgene which can be found here.

This Fellowship is currently closed for applications. 

For all enquiries please contact Charlotte Bell (charlotte.bell@medsci.ox.ac.uk).

If you would like to informally discuss an application with Celgene representatives please contact Phillipa Wells (philippa.wells@kennedy.ox.ac.uk)

JOINT STEERING COMMITTEE

Professor Sir Marc Feldmann (Oxford)

Professor Fiona Powrie (Oxford)

Professor Chas Bountra (Oxford)

Dr. Maxine Allen (Oxford)

Dr. Rupert Vessey (Celgene)

Leon Carayannopoulos (Celgene)

James Carmichael (Celgene)

 Current Fellows

Hannah Chen.jpg

Hannah CheN

Research Fellow, NDM

'Definition of new drug targets for fibrosis in Crohns'

PI: Alison Simmons

Liliana Cifuentes.jpg

Liliana Cifuentes

Clinical Research Fellow, NDORMS

'Protein kinase C-θ and PD-1 as a therapeutic target in inflammatory arthritis'

PI: Graham Ogg, Peter Taylor, Mike Dustin

Thomas Layton.jpg

Thomas Layton

Clinical Research Fellow, NDORMS 

'Single cell analysis of the fibrotic landscape in Dupuytren's Disease'

PI: Jagdeep Nanchahal

Michael Fitzpatrick.jpg

MICHAEL FITZPATRICK

Clinical Research Fellow, NDM

'Use of unbiased T-cell receptor repertoire sequencing to identify novel T-cell subsets involved in coeliac disease and increase the accuracy of the diagnosis of gluten sensitivity'

PI: Elizabeth Soilleux, Paul Klennerman

Heidi Olzscha.png

HEIDI OLZSCHA

Postdoctoral Researcher, Department of Oncology

'Unravelling the role of E2F-1 citrullination in inflammatory disease'

PI: Nick La Thangue

 

Tariq Khoyratty.jpg

TARIQ KHOYRATTY

Postdoctoral Research Fellow, NDORMS

'Defining an early signature of neutrophil extracellular trap formative predictive of responses to PAD4/2 inhibitors in rheumatic patients'

PI: Irina Udalova, Raashid Luqman

Image of Sarah Gooding

SARAH GOODING

Research Fellow, RDM

'Determining changes in clonal/sub clonal architecture and relation to immune marrow environment enabling tumour persistence/relapse in myeloma'

PI: Paresh Vyas, Udo Oppermann, Karthik Ramasamy

Nora Bengoa-Vergniory.jpg

Nora Bengoa-Vergniory

Postdoctoral Research Scientist, DPAG

'Inhibition of alpha-synuclein
aggregation and glial activation as a therapeutic strategy for Parkinson’s disease'

PI: Richard Wade-Martins

MelanieDunstan.jpg

MELANIE DUNSTAN

Research Fellow

'Ultra low-dose IL-2 therapy in autoimmune diabetes'

PI: John Todd, Claudia Monaco

SarahSasson.jpg

Sarah sasson

Post-doctoral Clinical Research Fellow, Translational Gastroenterology Unit (NDM)

'Checkpoint blockade-mediated autoimmune colitis as a model for gut immune homeostasis'

PI: Paul Klenerman, Oliver Brain

Past Fellows

Lynn Quek.png

LYNN QUEK

Research Fellow and Clinical Haematologist, RDM

'Clonal and Functional heterogeneity in AG221-treated IDH2 mutant Acute Myeloid Leukaemia'

PI: Paresh Vyas

 

                                                                                                                                              

                                                                     

PKC-Θ AND PD-1 AS A THERAPEUTIC TARGET IN INFLAMMATORY ARTHRITIS

Supervisors: Professor Peter Taylor (Oxford), Professor Michael Dustin (Oxford), Professor Graham Ogg (Oxford) and Leon Carayannopoulos (Celgene) and Rolli Khattri (Celgene)

This project will apply advanced imaging and use of small molecule inhibitors to understand the role of PKC-θ in the pathobiology of inflammatory arthritis. In conventional T cells PKC-θ co-localises with the TCR and is necessary for downstream signals, whereas in regulatory T cells PKC-θ adopts a distal position and negatively regulates suppressive function. This study will examine the localisation and function of PKC-θ in conventional and regulatory T cells from patients with inflammatory arthritis or healthy controls. Insight provided by these studies will guide development of PKC-θ small molecule inhibitors as therapeutic agents. The co-inhibitory molecule PD-1 is upregulated on chronically stimulated T cells and delivers signals that inhibit T cell function. These studies will also evaluate the combination of PD-1 agonists and PKC-θ inhibitors as an approach to inhibit T cell responses.

UNRAVELLING PRO-FIBROTIC TNF SIGNALLING PATHWAYS IN DUPUYTREN'S DISEASE

Supervisors: Professor Jagdeep Nanchahal (Oxford), Dr. Dominic Furniss (Oxford), Professor Kim Midwood (Oxford) and Welin Xie (Celgene) and Jerry Horan (Celgene)

Dupuytren's disease is a fibrotic disorder of the hand in which the fingers progressively curl irreversibility into the palm. Recent studies showed TNF converts palmar fibroblasts from Dupuytren's patients into myofibroblasts that are responsible for matrix deposition and contraction in fibrotic disorders. The goal of this project is to identify pro-fibrotic TNF signalling pathways for development of highly specific therapeutics in Dupuytren's and other fibrotic disorders. Planned studies will investigate the molecular pathway through which TNF cooperates with canonical Wnt signalling to promote palmer fibroblast cell differentiation as well as the upstream regulators of TNF secretion. These studies will apply ex vivo models using samples from disease tissues. Data generated by these studies will complement a clinical trial of TNF inhibition for early Dupuytren's disease.

DEFINITION OF NEW DRUG TARGETS FOR FIBROSIS IN CROHN'S

Supervisors: Professor Alison Simmons (Oxford) and Kamal Puri (Celgene)

Fibrosis is a common complication of inflammatory bowel disease that is neither prevented nor reversed by current anti-inflammatory therapies. This project will apply new methodologies for isolation and molecular phenotyping of stromal cells from colonic or small bowel biopsies. This analysis will allow reclassification of intestinal stromal subsets and will provide insight into subset composition in IBD or IBD fibrotic tissues compared with healthy controls. In addition, stromal cells subsets isolated during different stages of disease will be examined for responses to innate stimuli to uncover molecules or pathways that contribute to the pro-fibrotic state. This project will advance mechanistic understanding of intestinal fibrosis in human disease and may reveal targets for development of biomarkers or new therapies.