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The following projects were funded by the Medical and Life Sciences Translational Fund in November 2024:

 

 

  • Cell-Permeant Antibodies and Other Biomacromolecules to Treat Cancer - Vallis, Katherine (Oncology)
  • Further evaluation of the efficacy of a novel mirtron-based knockdown/replacement gene therapy for the mutation-independent treatment of RHO-related autosomal dominant retinitis pigmentosa - MacLaren, Robert (Clinical Neurosciences)
  • UniClo: Universal DNA assembly - development as a completely cell-free process. - O'callaghan, Christopher (The Centre for Human Genetics)
  • Microvascular imaging for drug development trials - Lapidaire, Winok (RDM Cardiovascular Medicine)
  • Can we target CLIC5 on fibroblasts to control the tissue-damage in inflamed joints? - Bezbradica Mirkovic, Jelena (NDORMS – Kennedy)
  • Development of bispecific macrophages engagers as cancer vaccines by promoting tumour antigen cross-presentation - Seymour, Leonard W (Oncology)
  • Lineage-targeted iron blockade - developing a therapeutic platform, with POC in polycythaemia vera - Drakesmith, Alexander (RDM Investigative Medicine)
  • Rescuing genetic cardiomyopathy through disruption of TPNI/PDE interaction - Chao, Ying-Chi (Physiology Anatomy and Genetics)
  • A novel therapeutic for radiotherapy-induced oral mucositis - Ruan, Jia-Ling, Oncology
  • Validation of a Novel Dynamic Joint Assessment System for Orthopaedics - Mellon, Stephen (NDORMS – Botnar)
  • Evaluating single visit post-exposure prophylaxis treatment for rabies, using a novel rabies vaccine - Ritchie, Adam (Jenner Institute)
  • uORF-adenine base editing for therapeutic BDNF upregulation, Roberts, Thomas, Paediatrics
  • Novel amphiphilic cell-penetrating peptide for efficient and safe delivery of therapeutic oligonucleotide - Wood, Matthew J A (Paediatrics)
  • Pre-clinical evaluation of an Epstein-Barr virus (EBV) vaccine for the prevention of Burkitt's lymphoma relapse - Leung, Carol Sze Ki (Centre for Immuno-Oncology)
  •  Engineering a mechanochemical T cell expansion technology: In vivo animal model validation - Fritzsche, Marco (NDORMS – Kennedy)
  • CD8+CD103+ Tissue resident memory T cells from human malignant pleural effusion as an Advanced Therapy Medicinal Product - translational studies to move towards human trials.  - Rahman, Najib (NDM Experimental Medicine)
  • Next generation HIV-specific broadly neutralising antibody discovery through massively deep B cell repertoire sequencing of HIV controllers - Frater, John (RDM Experimental Medicine)