Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Researchers have developed a vaccine that blocks the effects of the main cause of pain in osteoarthritis (OA) - nerve growth factor (NGF) – in mice.

None © Shutterstock

In a collaborative effort between the Jenner Institute and the Kennedy Institute of Rheumatology at the University of Oxford, with colleagues in the University of Bern, and the Latvian Biomedical Research & Study Centre, scientists have developed and tested a vaccine that could be used to treat chronic pain caused by osteoarthritis, by blocking the cause of the pain – NGF.

The researchers developed a virus-like particle vaccine that triggers the immune system to produce antibodies to block naturally-occurring NGF. The new vaccine was tested in mice that had signs of painful OA (uneven distribution of weight across the hind legs), and it was shown to visibly reverse these effects.

Read more (University of Oxford website)

Similar stories

Student Prizes for Biomedical Sciences and Medicine 2020-2021

Awards and Appointments General

Congratulations to all our Biomedical Sciences students and Medicine students who have been awarded prizes during the 2020-2021 academic year.

Multi-partner 'OpenMind' consortium to develop technology for new generation of neurostimulation devices

General Research

Investigators at the University of Oxford, University of California San Francisco (UCSF), Brown University and the Mayo Clinic have joined forces to develop open-source technology platforms for a new generation of neurostimulation devices that not only provide stimulation to the brain but also sense, record, and stream brain activity.

Why we must expand newborn screening

General Research

Professor Laurent Servais of the Department of Paeditrics writes for the Oxford Science Blog on why it is important that we become much more efficient in the diagnosis of treatable conditions and in the treatment of these diseases.

Top place for Oxford Clinical Medical Student in prestigious national Ophthalmology Duke Elder Prize Examination

Awards and Appointments General

Sixth year Clinical Medical student, Ryan Purdy (Worcester College), placed first in the Royal College of Ophthalmology's annual Prize Examination.