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A national study has found that a significant proportion of clinically at-risk patients with certain immunocompromised or immunosuppressed conditions, mount a low, or undetectable, immune response after two doses of the same COVID-19 vaccine.

Needle going into an arm

The ongoing multi-centre OCTAVE study is evaluating the immune responses following COVID-19 vaccination in patients with immune-mediated inflammatory diseases such as cancer, inflammatory arthritis, diseases of the kidney or liver, or patients who are having a stem cell transplant. Initial data from the study have been published on the Lancet pre-print site

The study is led by the University of Glasgow and co-ordinated by the University of Birmingham’s Cancer Research UK Clinical Trials Unit. Researchers from Oxford University Hospitals (OUH) and the University of Oxford’s Nuffield Department of Medicine are leading the research involving patients with gastrointestinal diseases.

Read the full story on the University of Oxford website

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