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The results of a placebo-controlled trial of remdesivir in COVID-19 patients have been published in the Lancet.

In early February scientists in China, supported by the ISARIC Support Centre at the University of Oxford, launched a placebo-controlled randomised trial of remdesivir in patients hospitalised with COVID-19.

The results, published today in the Lancet, found no significant clinical benefit from use of the drug. However, while not statistically significant, the time to clinical improvement and duration of invasive mechanical ventilation were shorter in people treated with remdesivir within 10 days after illness onset, compared to standard care.

One hundred and fifty-eight patients were randomised to remdesivr and 79 patients were randomised to placebo for 14 days. The trial had to be stopped early due to lack of patients, which meant the trial was underpowered and the results are inconclusive.

Professor Peter Horby, a co-investigator on the trial, said: 'It is an outstanding achievement of Dr Cao Bin and his team to have completed a gold-standard clinical trial in the very early days of a major emergency. It is disappointing that we did not see a clear benefit from remdesivir. However, there were suggestions of a possible benefit, particularly in those treated earlier. Ongoing, bigger trials will confirm or refute these findings.'

Read the full story on the University of Oxford website

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