Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The University of Oxford and the Ifakara Health Institute today announced the vaccination of the first participants in a Phase Ib/II trial testing a novel rabies vaccine in human volunteers in Tanzania.

Artist's impression of the rabies virus

The new RAB002 trial builds on encouraging results from a recent, smaller study of the same vaccine in the UK. Up to 192 healthy people will be randomly assigned to receive one dose of Oxford’s ChAdOx2 RabG vaccine, or one or two doses of a currently licensed rabies vaccine. The study aims to show whether a single dose of the Oxford vaccine has the potential to induce protective immune responses comparable to existing vaccines.

Dr Sandy Douglas, Research Group Leader and Chief Investigator of the trial, said: ‘Many people are unaware that rabies still kills about 50,000 people every year, mostly in Asia and Africa – it’s the only known viral infection with essentially 100% fatality. Current rabies vaccines are effective but they require multiple doses and they’re too expensive for broad use. A single-dose, low cost vaccine would be a game changer – this trial should show us whether our new vaccine could provide that.’

Read the full story on the University of Oxford website

Similar stories

New evidence for how our brains handle surprise

A new study from the Bruno Group is challenging our perceptions of how the different regions of the cerebral cortex function. A group of ‘quiet’ cells in the somatosensory cortex that rarely respond to touch have been found to react mainly to surprising circumstances. The results suggest their function is not necessarily driven by touch, but may indicate an important and previously unidentified role across all the major cortices.

Language learning difficulties in children linked to brain differences

A new study using MRI has revealed structural brain changes in children with developmental language disorder (DLD), a common but under-recognised difficulty in language learning. Children with DLD aged 10-15 showed reduced levels of myelin in areas of the brain associated with speaking and listening to others, and areas involved in learning new skills. This finding is a significant advance in our understanding of DLD and these brain differences may explain the poorer language outcomes in this group.

The Gene Therapists Headline at Glastonbury 2022

Rosie Munday writes about her experience taking science to the masses at the Glastonbury Festival.

New research reveals relationship between particular brain circuits and different aspects of mental wellbeing

Researchers at the University of Oxford have uncovered previously unknown details about how changes in the brain contribute to changes in wellbeing.

Night-time blood pressure assessment is found to be important in diagnosing hypertension

Around 15% of people aged 40-75 may have a form of undiagnosed high blood pressure (hypertension) that occurs only at night-time. Because they do not know about this, and therefore are not being treated for it, they are at a higher risk of cardiovascular disease such as stroke, heart failure, and even death, suggests new research from the University of Oxford published in the British Journal of General Practice.