Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

It is with profound sadness that we learnt of the death of Professor Vincenzo Cerundolo FRS.

Professor Cerundolo was Director of the MRC Human Immunology Unit at the MRC Weatherall Institute of Molecular Medicine, Oxford, Fellow of the Royal Society, Fellow of the Academy of Medical Sciences, Head of Department of Investigative Medicine, Radcliffe Department of Medicine, and Fellow of Merton College.  His work focused on understanding mechanisms of processing and presentation of lipid and peptide antigens to T cells.  There were many seminal findings, including work with Alain Townsend FRS and colleagues, in which it was found that genes in the MHC region encode transporter proteins which translocate peptides for eventual presentation by MHC class I; and in subsequent studies, Enzo went on to lead a study describing a clinical syndrome associated with defective peptide transport. More recently, Enzo helped define the structural and functional basis for the T cell recognition of lipids bound to CD1 molecules, with consequent enhancement of antibody and peptide-specific T cell responses. The collective findings have broad relevance across immunology, including for mechanisms of inflammation, immuno-oncology and vaccination, with key discoveries being taken forward to clinical trials.

Read more (MRC Weatherall Institute of Molecular Medicine)

Similar stories

Peter Horby receives prestigious award for outstanding service to public health

The Faculty of Public Health (FPH) has awarded its prestigious Alwyn Smith Prize to Professor Sir Peter Horby (Nuffield Department of Medicine) for 2020/2021 in recognition of his outstanding service to public health as a global leader in epidemic science.

Six new Fellowships announced as part of Oxford-Bristol Myers Squibb Fellowships Programme

The Oxford - Bristol Myers Squibb (BMS) Fellowships Programme continued to demonstrate significant progress over the last year, despite the challenges associated with the global pandemic, including restricted lab access and work from home guidance. Today, we are pleased to announce six new Oxford-BMS Fellowships for 2021.

Researchers set out steps to address mental health effects of the pandemic on young people

Researchers have outlined 14 steps that schools, mental health services and policymakers can take to help children and young people whose mental health has been affected by the COVID-19 pandemic.

Anti-cancer drug derived from fungus shows promise in clinical trials

A new industry-academic partnership between the University of Oxford and biopharmaceutical company NuCana as found that chemotherapy drug NUC-7738, derived from a Himalayan fungus, has 40 times greater potency for killing cancer cells than its parent compound.

Professor Trish Greenhalgh Highly Commended in the O²RB Excellence in Impact Awards 2021

Congratulations to Professor Trish Greenhalgh (Nuffield Department of Primary Care Health Sciences) who has been Highly Commended in the O²RB Excellence in Impact Awards 2021.

No benefit of convalescent plasma for critically ill COVID-19 patients

A large study of over 2000 COVID-19 patients has found that giving critically ill patients blood plasma from recovered COVID-19 patients did not significantly reduce deaths, or the need for intensive care support such as being put on a ventilator machine.