Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

It is with profound sadness that we learnt of the death of Professor Vincenzo Cerundolo FRS.

Professor Cerundolo was Director of the MRC Human Immunology Unit at the MRC Weatherall Institute of Molecular Medicine, Oxford, Fellow of the Royal Society, Fellow of the Academy of Medical Sciences, Head of Department of Investigative Medicine, Radcliffe Department of Medicine, and Fellow of Merton College.  His work focused on understanding mechanisms of processing and presentation of lipid and peptide antigens to T cells.  There were many seminal findings, including work with Alain Townsend FRS and colleagues, in which it was found that genes in the MHC region encode transporter proteins which translocate peptides for eventual presentation by MHC class I; and in subsequent studies, Enzo went on to lead a study describing a clinical syndrome associated with defective peptide transport. More recently, Enzo helped define the structural and functional basis for the T cell recognition of lipids bound to CD1 molecules, with consequent enhancement of antibody and peptide-specific T cell responses. The collective findings have broad relevance across immunology, including for mechanisms of inflammation, immuno-oncology and vaccination, with key discoveries being taken forward to clinical trials.

Read more (MRC Weatherall Institute of Molecular Medicine)

Similar stories

General anaesthesia should be available for dying patients - medical and ethical experts

General Research

General anaesthesia should be more widely available for patients at the end of their lives, according to Oxford experts in ethics and anaesthesia, according to a paper published by Anaesthesia (a journal of the Association of Anaesthetists).

Human challenge trial launches to study immune response to COVID-19

Clinical Trials Coronavirus COVID-19 General

Though the COVID-19 pandemic has now been active for a year, not much is known about what happens when people who have already had COVID-19 are infected for a second time.

Alternating vaccines trial expands to include two additional vaccines

Clinical Trials Coronavirus COVID-19 General

Researchers running the Com-Cov study, launched in February to investigate alternating doses of the Oxford-AstraZeneca vaccine and the Pfizer vaccine, have today announced that the programme will be extended to include the Moderna and Novavax vaccines in a new study.

Oxford medical students launch flagship raffle in aid of NHS heroes and lifesaving medical equipment

General

Tingewick, a society formed of medical students from Oxford University, are hosting a virtual charity raffle. With over 70 amazing prizes, ranging from Truck festival tickets to restaurant vouchers to bags of books and even a bike, the raffle is an exciting way to celebrate lockdown lifting by supporting many wonderful Oxfordshire businesses whilst raising lots of money for charity.

UK and EU regulators conclude benefits of vaccination continue to outweigh the risks

Coronavirus COVID-19 General

Today, the medical regulators in the UK and Europe have announced their conclusions from their reviews of very rare cases of unusual blood clots in people who have received the Oxford-AstraZeneca coronavirus vaccine.