Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Research from Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences (NDORMS) shows how IL-22 interacts with KRAS mutant tumours to promote excessive growth in colorectal cancer

Cancer attacking a cell in the colon © Shutterstock

Colorectal cancer (CRC) is the third most common cancer worldwide and the fourth leading cause of cancer-related deaths. For patients, current therapy primarily entails surgical removal of the tumour and chemotherapy, to which tumours are variably responsive.

The immune system can be a double-edged sword in cancer because it can both combat and contribute to tumour development. The Powrie Group at the Kennedy Institute of Rheumatology (NDORMS) were interested understanding the role of molecule IL-22, produced by immune cells, and to identify mechanisms by which it might influence CRC.

Their research published in Clinical Cancer Research found a link between the receptor for IL-22 and a mutation in the gene KRAS, showing that they work cooperatively to promote excessive growth and division of tumour cells. This is hypothesised to explain why prognosis is significantly worse for patients whose tumours have both a mutation in KRAS and high expression of the IL-22 receptor.

The full article is available on the NDORMS website

Similar stories

Human challenge trial launches to study immune response to COVID-19

Clinical Trials Coronavirus COVID-19 General

Though the COVID-19 pandemic has now been active for a year, not much is known about what happens when people who have already had COVID-19 are infected for a second time.

Risk of rare blood clotting higher for COVID-19 than for vaccines

Coronavirus COVID-19 Research

COVID-19 leads to a several-times higher risk of cerebral venous thrombosis (CVT) blood clots than current COVID-19 vaccines.

Alternating vaccines trial expands to include two additional vaccines

Clinical Trials Coronavirus COVID-19 General

Researchers running the Com-Cov study, launched in February to investigate alternating doses of the Oxford-AstraZeneca vaccine and the Pfizer vaccine, have today announced that the programme will be extended to include the Moderna and Novavax vaccines in a new study.

Oxford medical students launch flagship raffle in aid of NHS heroes and lifesaving medical equipment

General

Tingewick, a society formed of medical students from Oxford University, are hosting a virtual charity raffle. With over 70 amazing prizes, ranging from Truck festival tickets to restaurant vouchers to bags of books and even a bike, the raffle is an exciting way to celebrate lockdown lifting by supporting many wonderful Oxfordshire businesses whilst raising lots of money for charity.

Asthma drug budesonide shortens recovery time in non-hospitalised patients with COVID-19

Clinical Trials Coronavirus COVID-19 Research

Inhaled budesonide, a common corticosteroid, is the first widely available, inexpensive drug found to shorten recovery times in COVID-19 patients aged over 50 who are treated at home and in other community settings, reports the PRINCIPLE trial in 1,779 participants.