Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Dr Joris Hemelaar, University Research Lecturer and expert in maternal HIV infection at the Nuffield Department of Women's & Reproductive Health, published a new article: "Global and regional epidemiology of HIV-1 recombinants in 1990-2015" in the Lancet HIV.

Front cover of November 2020 Lancet HIV Journal

Global HIV-1 genetic diversity and evolution form a major challenge to treatment and prevention efforts. An increasing number of distinct HIV-1 recombinants have been identified worldwide (106 distinct recombinants to date), but their contribution to the global epidemic was hitherto unknown.

Dr Hemelaar's article: "Global and regional epidemiology of HIV-1 recombinants in 1990-2015: a systematic review and global survey" is the first study to describe the global and regional distribution of HIV-1 recombinants (viruses that are the result of a cross-over between two or more different strains of HIV). This study is based on nearly 400,000 HIV samples covering the period 1990 to 2015. The global and regional distribution of HIV-1 recombinants was found to be extremely diverse and evolve over time. The number and proportion of recombinants is increasing worldwide, reaching 22.8% of global HIV-1 infections in 2010-2015. Recombinants play prominent roles in several regions, including in sub-Saharan Africa, East and South-east Asia, Middle East and North Africa, Eastern Europe and central Asia, and Latin America. This demonstrates the way the HIV pandemic is evolving and highlights the increasing challenge facing the development of a globally effective HIV vaccine as well as the need for ongoing adaptation of HIV diagnostic, drug resistance, and viral load assays.

The full story is available on the Nuffield Department of Women's and Reproductive Health website

Similar stories

Oxford vaccine reaches one billion doses released

The University of Oxford’s and our partners AstraZeneca have today announced that one billion doses of the ChAdOx1 nCov-19 coronavirus vaccine have been released, to more than 170 countries, marking a key milestone as part of the University and AstraZeneca’s joint vision to make the available to the world, on a not-for-profit basis for the world during the pandemic, and in perpetuity for low- and middle-income countries.

Research programme tackling COVID-19 variants of concern receives funding boost

A gift from the Red Avenue Foundation will enable the expansion of a major research programme aimed at rapidly identifying and interrogating emerging COVID-19 variants.

Phase I trial begins of new vaccine against the Plague

Researchers at the University of Oxford today launched a Phase 1 trial to test a new vaccine against plague.

New therapeutic targets identified in the treatment of psoriatic arthritis

Researchers identify two inflammatory-driving proteins, osteopontin and CCL2, highly expressed in psoriatic arthritis joints.

Treatment choice for rotator cuff disorders could create efficiency and savings for the NHS

A trial that evaluated the clinical and cost effectiveness of physiotherapy treatments for rotator cuff disorders suggests cost savings can be made while maintaining positive patient outcomes.