Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

First in a new blog series by Cancer Research UK Oxford Centre on the ongoing work happening across Oxford, for Blood Cancer Awareness Month.

Stem cell © CRUK Assets Hub

Allogenic stem cell transplantation (allo-SCT) is one of the most common, curative forms of cancer immunotherapy. It has been a treatment option for patients with blood cancers (including leukaemia, lymphoma and myeloma) for over 60 years.

In this type of transplant, a patient receives blood stem and immune cells from another healthy person (a donor). Although the initial aim of allo-SCT was to replenish the blood cell producing capacity that patients lose during harsh chemo- and radio-therapy treatment regimes, clinicians and researchers soon realised that donor immune cells specifically destroy the remaining cancer cells through an effect called “graft-vs-tumour”.

This remarkable curative treatment option is a standard treatment, which is routinely used in younger patients with otherwise incurable blood cancers. However, the treatment is associated with significant side effects and can result in 5-25% mortality within the first 100 days of receiving treatment. This toxicity limits wider use of the treatment.

Read the full blog on the Cancer Research UK Oxford Centre website

Similar stories

Oxford spinout Optellum secures $14m funding to advance pioneering AI-powered lung cancer diagnosis technology

Optellum, a University of Oxford spinout that provides a breakthrough AI platform to diagnose and treat early-stage lung cancer, has raised $14 million in a Series A funding round.

New study shows higher rate of fractures in people with intellectual disability

In the most comprehensive study of its kind, researchers at the University of Oxford and Oxford Health NHS Foundation Trust found a substantially higher rate of fractures in people with intellectual disability compared with people of the same age and gender without an intellectual disability.

New evidence for how our brains handle surprise

A new study from the Bruno Group is challenging our perceptions of how the different regions of the cerebral cortex function. A group of ‘quiet’ cells in the somatosensory cortex that rarely respond to touch have been found to react mainly to surprising circumstances. The results suggest their function is not necessarily driven by touch, but may indicate an important and previously unidentified role across all the major cortices.

Language learning difficulties in children linked to brain differences

A new study using MRI has revealed structural brain changes in children with developmental language disorder (DLD), a common but under-recognised difficulty in language learning. Children with DLD aged 10-15 showed reduced levels of myelin in areas of the brain associated with speaking and listening to others, and areas involved in learning new skills. This finding is a significant advance in our understanding of DLD and these brain differences may explain the poorer language outcomes in this group.

The Gene Therapists Headline at Glastonbury 2022

Rosie Munday writes about her experience taking science to the masses at the Glastonbury Festival.