Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

First in a new blog series by Cancer Research UK Oxford Centre on the ongoing work happening across Oxford, for Blood Cancer Awareness Month.

Stem cell © CRUK Assets Hub

Allogenic stem cell transplantation (allo-SCT) is one of the most common, curative forms of cancer immunotherapy. It has been a treatment option for patients with blood cancers (including leukaemia, lymphoma and myeloma) for over 60 years.

In this type of transplant, a patient receives blood stem and immune cells from another healthy person (a donor). Although the initial aim of allo-SCT was to replenish the blood cell producing capacity that patients lose during harsh chemo- and radio-therapy treatment regimes, clinicians and researchers soon realised that donor immune cells specifically destroy the remaining cancer cells through an effect called “graft-vs-tumour”.

This remarkable curative treatment option is a standard treatment, which is routinely used in younger patients with otherwise incurable blood cancers. However, the treatment is associated with significant side effects and can result in 5-25% mortality within the first 100 days of receiving treatment. This toxicity limits wider use of the treatment.

Read the full blog on the Cancer Research UK Oxford Centre website

Similar stories

Professor Dame Sarah Gilbert delivers 44th Dimbleby Lecture

Professor Dame Sarah Gilbert, Saïd Professorship of Vaccinology, Jenner Institute & Nuffield Department of Clinical Medicine, delivered the 44th Richard Dimbleby Lecture, named after the late broadcaster, Richard Dimbleby.

Com-COV2 study supports flexible second dose options following Pfizer or Oxford/AstraZeneca jabs

Following up first doses of the Oxford-AstraZeneca or Pfizer-BioNTech vaccines with second doses of the Moderna or Novavax jabs will generate robust immune responses against COVID-19, according to researchers running the University of Oxford-led Com-COV study.

Meta must do better - data from social media giant essential to mental health research

People are rightly sceptical about scientific discoveries made in secret or without scrutiny. And anyone claiming to have found a new planet with a toy telescope, would not be taken seriously. Recent leaks of internal Facebook research on the mental health of children and young people have caused a great stir on both sides of the Atlantic.

New Oxford-GSK Institute to harness advanced technology and unravel mechanisms of disease

GlaxoSmithKline plc and the University of Oxford today announced a major five-year collaboration to establish the Oxford-GSK Institute of Molecular and Computational Medicine.

Oxford researchers honoured by British Society for Immunology

Four researchers from the University of Oxford have been recognised for their outstanding contributions to immunology with Honorary Lifetime Membership of the British Society for Immunology, with the awards being announced at the recent British Society for Immunology Congress held in Edinburgh.

Medical Sciences researchers scoop 2021 Times Higher Education Awards

Coronavirus researchers from across Medical Sciences have been honoured at the 2021 Times Higher Education (THE) Awards.