Checkpoint inhibitors (CPIs) are a type of cancer treatment that help the immune system fight cancer by removing some of its restraints. However, these treatments often cause debilitating side effects, including inflammation of the colon called colitis.
In this study, published in Cancer Cell, the research team used single cell and spatial analysis methods to paint a detailed picture of how these beneficial cancer therapies can sometimes lead to harmful side effects. This information could help to develop new ways to prevent and treat the side effects, without reducing the drugs’ cancer-fighting capabilities.
The study explored how CPIs lead to colitis by examining the behaviour and characteristics of T cells, a type of immune cell, in the colons of patients treated with these drugs. The researchers analysed both where the T cells were found within tissues and which genes were being expressed in the cells. They found that certain T cells in the gut still carried the CPI drug many weeks after it had been administered. These T cells behaved differently from other T cells and were found in distinct areas of the colon, suggesting that the CPI drugs modified their behaviour and possibly contributed to the development of colitis.