In partnership with Imperial College London and the Uganda Virus Research Institute, the Lymph nodE single-cell Genomics AnCestrY (LEGACY) Network will create an ethnically diverse single-cell atlas of the response to commonly used vaccines such as flu vaccine with a focus on responses in lymph nodes. The LEGACY vision is to understand and ultimately to predict how humans respond to vaccination at a single-cell level, whilst simultaneously creating universally available on-line materials as resources for further research.
The Oxford team includes a number of investigators across several departments:
- Dr Calliope Dendrou and Dr Anita Milicic (Nuffield Department of Medicine);
- Profs Mark Coles and Brian Marsden (Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences);
- Prof Hashem Koohy (Radcliffe Department of Medicine); and
- Prof Teresa Lambe and Dr Samantha Vanderslott (Paediatrics).
The Oxford researchers will analyse samples provided by Imperial College using single-cell technology and genetic, functional and serological assays to generate the atlas and data resource. The funds cover the costs of sample analysis, creation of the team performing the functional and computational analyses, community outreach initiatives and training costs for capacity building in Uganda.