Kate Attfield
Principal Investigator
Physical and mental disability caused by neuroinflammation is a common clinical occurrence in many diseases, including multiple sclerosis (MS), Alzheimer’s disease and schizophrenia. However, the cause(s) of this inflammation and the devastating consequences that ensue are poorly defined, as reflected by a lack of effective treatments.
As demonstrated by our previous work, with a particular focus on multiple sclerosis, we have shown how studying individual cells directly from patient blood or mapping biological events across the diseased brain in post-mortem tissue, can expose an intricate network of neuroinflammatory processes, which change through time and space. With evolving technologies, our research team seeks to understand how the immune system and resident cells of the central nervous system orchestrate these disease processes.