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Jen Southcombe

Jen Southcombe

Biography

I completed my undergraduate degree in Biochemistry and Molecular Biology at the University of Leeds, then moved to the University of Oxford to the Human Immunology Unit, Weatherall Institute of Molecular Medicine, and obtained a DPhil working with Professors Xiaoning Xu and Gavin Screaton. I joined the Nuffield Department of Obstetrics and Gynaecology in 2007, to work on Immunology in Pre-eclampsia with Professors Ian Sargent and Chris Redman. My work focused on studying placental derived factors that contribute to maternal systemic inflammatory changes in pregnancy and pre-eclampsia. A key aspect of this work was studying the interactions between syncytiotrophoblast microvesicles and exosomes with immune cells in pregnancy.

Research groups

Jen Southcombe

BSc (hons), DPhil (oxon)


Researcher in Reproductive Science

I research immunity in the female reproductive tract, with specific focus on understanding immunological events that lead to pregnancy success. Together with Dr Ingrid Granne, I am aiming to further understand the nature of uterine immunity pre-pregnancy and immunological events that unfold in early pregnancy, to help women suffering from unexplained infertility, Recurrent Implantation Failure and Recurrent Pregnancy Loss.

 

Research Interests

  • Endometrial immune cells and their role in fertility and recurrent pregnancy loss

  • Detailed analysis of T cell populations in the endometrium
  • The interactions of seminal fluid extracellular vesicles with maternal endometrial cells

  • Embryo factors that enhance implantation

  • The PIP Study - Pre- IVF Immune Profiling Study (PIP)

 

Opportunities to work with us

Speculative enquires from people wishing to work with us are always welcome and should be made in the first instance by e-mail to myself or Dr Ingrid Granne