Research Project
Doctoral Training Project:
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Anuj Goel
MBBS, MSc
Associate Professor of Cardiovascular Genetics
My research focuses on advancing the understanding of cardiovascular disease through large-scale human genetics and bioinformatics. I apply genome-wide association studies and meta-analyses to identify genetic loci associated with complex cardiovascular traits, with particular interests in coronary artery disease and hypertrophic cardiomyopathy.
A key aim of my work is to move beyond association signals to identify causal variants and underlying biological mechanisms, integrating computational approaches with epigenetic and multi-omic data. I also use whole-genome sequencing and rare variant analyses to better define disease pathways and improve risk prediction.
I also manage the PROCARDIS study (https://www.well.ox.ac.uk/procardis), a large-scale resource for investigating the genetic basis of coronary artery disease. In parallel, I am currently co-leading the new discovery efforts within the CARDIOGRAMplusC4D consortium (http://www.cardiogramplusc4d.org), driving large-scale collaborative analyses to identify novel genetic determinants of coronary artery disease. I am further involved in collaborative genetic discovery efforts in hypertrophic cardiomyopathy, aiming to refine disease biology and improve clinical translation.
By combining large-scale datasets with advanced analytical methods, my goal is to translate genetic discoveries into mechanistic insight and contribute to more precise strategies for the prevention and treatment of cardiovascular disease.