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17 projects were funded from the 2011-2012 ISSF and matched funds. For the first year, 25% of the total project costs were met by a block grant from the University John Fell Fund for Research; the remainder came from Departmental resources or applications for additional internal funding.

Education and Outreach

  •  ‘Oxford University clinical academic graduate school (OUCAGS) education and career support’ Ken Fleming, Christopher Pugh, Alastair Buchan. Funding for flexible research bursaries, for a professional development officer and contribution towards cost of research training modules. (MSD)
  •  ‘Improving access of clinical trainees to biomedical research opportunities in Oxford’ Christopher Pugh, Paul Klenerman, Helen McShane, Alison Simmons, Tim Lancaster, Anne Edwards.  Funds will support a series of initiatives to promote awareness of research opportunities among clinical trainees (including research fairs, a weekly academic forum, and presentations at student grand rounds), together with specific support for high performing F1 trainees to switch to an academic foundation option in F2. (MSD)
  •  ‘Biomedical engineering initiative and the developing world: student bursaries’ Lionel Tarassenko, Alison Noble, Sue Dopson. Funding in an area of need that links the Institute of Biomedical Engineering, the Saïd Business School and Wellcome Trust-funded major overseas programs, and addresses new electronic/telemedicine opportunities for healthcare organization/delivery. (MPLS/SSD)
  •  ‘The challenge of urbanization: health and the global city’ Mark Harrison, Sue Dopson, Kevin Marsh. Funding will support junior research posts studying the health implications and threats arising from rapid urbanization in Asia. Projects will form new collaborations with existing infrastructures in South Korea (Korean Foundation) and New Delhi (International Network for Clinical Epidemiology, INCLEN) and link biomedical, social sciences and humanities research programs in Oxford. (HUM/SSD/MSD)
  •  ‘Flexible Small Grants Fund: identifying and responding to emerging opportunities and threats’ Sue Dopson, Mark Harrison, Kevin Marsh. Funds to create a programme of Flexible Small Grants, which will both enable us to respond to emerging opportunities, and develop new interdisciplinary research collaborations and themes of relevance to medicine and global health. (SSD/HUM/MSD)
  •  ‘Promoting interdisciplinary collaboration in global health’ Kevin Marsh, Sue Dopson, Mark Harrison. Funding to foster new collaborations between the Oxford Tropical Network and other groupings in all disciplines across the university.  It will provide small grants (£1,000 to a maximum of 10,000) to support collaborative travel or mini sabbaticals (one week to  three months) to allow university staff in Oxford to spend time in the Major Overseas Programmes and vice versa. (MSD/SSD/HUM)

Recruitment of strategic technical and support staff

  • ‘A bioinformatics platform for life science orientated mass spectrometry’ Benedikt Kessler, Oreste Acuto, Carol Robinson, Benjamin Thomas. Funding is for a senior bioinformatician who will work within the university’s ‘Computational Biology Research Group’ on tasks such as devising and implementing strategies for quantitation of large-scale comparative MS datasets. Provides added value to existing major investment in proteomics and MS technology, and supports multiple high-profile research groups across two divisions. (MSD/MPLS)
  • ‘Super-resolution cryo-microscopy for correlative studies of membranes in situ Yvonne Jones, Mark Sansom, David Stuart, Ilan Davis, Kay Grunewald, Francis Barr. Funds are for a senior postdoctoral scientist to implement a platform for super-resolution cryo-light microscopy, in collaboration with Diamond Light Source. The position will help fill a technological gap and ultimately permit correlation with X-ray microscopy techniques being developed at Diamond. The deployment complements many existing Wellcome Trust investments in this area within the university, and potentially will contribute to a national technological resource. (MSD)
  • ‘Functional neuroimaging infrastructure: physics and technical support staff’ Irene Tracey, Glyn Humphries. Funds are for contributions to two key support staff: highly skilled MR physicists who are vital for making complicated MR systems more useable for application neuroscientists. Aligns with major investments in neuroimaging by the Wellcome Trust. (MSD)
  • ‘Integrating diverse data streams in viral and immunological genetics’ Angela McLean and Rodney Phillips. Funds for a senior bioinformatician to support work on DNA sequence-based analysis of host-pathogen epidemiology and inter-relations, particularly determinants of viral clearance as exemplified by work on Hepatitis C. (MPLS/MSD)

Infrastructure support and strategic investment

  • ‘Infrastructure support for vaccine research in Oxford’ Helen McShane, Adrian Hill, Andrew Pollard. Funding to support key gaps in the pre-clinical to clinical pipeline for vaccine development, including contributions to a facility for transcriptomic analysis, the malaria program’s insectary and the clinical biomanufacturing unit. (MSD)
  • ‘Infrastructure support to develop Oxford’s chemistry-biology interface for (drug) target discovery’ Peter Ratcliffe, Adrian Harris, Gillies McKenna, Christopher Schofield, Daniel Ebner. Funds towards the purchase of pan-genomic shRNA, normalized cDNA and small annotated chemical libraries to support Oxford’s new initiative in drug target discovery. Facilities will be available across the university and elsewhere, through a business model retrieving marginal costs from users. (MSD/MPLS)

Strategic recruitment of senior academic staff

  • ‘Non-clinical fellowship in neuroscience’ Christopher Ponting. Funds enabled the retention of a key individual working on epigenetic variation and susceptibility to neurological disease. (MSD)
  • ‘Genomic medicine group leader’ Peter Donnelly, Gil McVean, Christopher Holmes. Funds for a ‘start-up’ package for a new group leader based principally in the Wellcome Trust Centre for Human Genetics, but providing university-wide input into genome sequence analysis. (MSD/MPLS)
  • ‘Informatics capacity in screening analyses’ Shoumo Bhattacharya, Alison Noble, Peter Ratcliffe. Funds for a ‘start-up’ package for a new group leader working between engineering science and medical science on computational aspects of cellular image analysis for screening. (MSD/MPLS)
  • ‘Senior appointment in tissue engineering for regenerative medicine’ Andrew Carr, Lionel Tarassenko. Funds for a ‘start-up’ package for a new cross-divisional Professorship of Orthopaedic Engineering, to be held between the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science and the Institute of Biomedical Engineering. (MSD/MPLS)
  • ‘Senior appointment in clinical pharmacology and experimental therapeutics’ Hugh Watkins, Alastair Buchan. Fund for a ‘start-up’ package to assist recruitment into the vacant Rhodes Chair of Clinical Pharmacology within the newly created Radcliffe Department of Medicine. The aim will be to develop clinical experimental programs with strong interactions with either or both of the university basic science programs in pharmacology/chemistry and large-scale clinical trials activity. (MSD)