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Cognitive problems are common in psychotic and mood disorders, affecting memory, attention, and everyday functioning, yet effective treatments remain limited.
The study, published in BMJ Mental Health, analysed electronic health records from 13,007 adults in the USA with a psychiatric diagnosis. Researchers compared cognitive symptoms over the 12 months following initiation of semaglutide with those associated with other antidiabetic treatments.
Semaglutide was associated with 17% to 19% fewer cognitive symptoms than two other commonly used diabetes drugs, and 25% fewer than no antidiabetic treatment; cognitive symptoms were similar to those seen with sitagliptin. Associations were strongest for memory problems and broader cognitive functions, and were most consistently observed in people with major depressive disorder.
Read the full story on the Department of Psychiatry website.