Contact information
Research groups
Felipe Galvez-Cancino
PhD
Group Leader
- Lab Head, Immune Regulation Laboratory
- Honorary Lecturer, UCL Cancer Institute
Bio
I lead the Immune-Regulation Laboratory, where we aim to define fundamental mechanisms that control anti-tumour immune responses, with the ultimate goal of developing novel therapeutics that impact patients and their families. To achieve this, we work closely with academic collaborators worldwide and maintain strong partnerships with biotechnology companies.
Since joining Oxford, I have established two funded research programmes. The first seeks to define and exploit antibody-dependent cellular phagocytosis (ADCP) in hepatocellular carcinoma, building on my recent discovery that regulatory CD4⁺ T cells function as a checkpoint for macrophage-mediated ADCP. By identifying the intratumoural phagocytes responsible for ADCP, together with the intrinsic and extrinsic signals that regulate their activity, this programme aims to inform the rational design of next-generation antibody therapies that harness this mechanism.
The second programme focuses on deciphering T cell reactivities and immune regulation in translocation-driven sarcomas, with the long-term objective of developing mRNA-based cancer vaccines to prevent relapse in paediatric and young adult patients.