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An internationally recognised centre of excellence for biomedical and clinical research and teaching
How monkeys and humans make novel choices
General Research
15 February 2021
Dr Alessandro Bongioanni, Postdoctoral Research Associate in the Department of Experimental Psychology, writes for the Oxford Science Blog on the way humans and other primates make first-time choices.
Oxford University extends COVID-19 vaccine study to children
Clinical Trials Coronavirus COVID-19 General
12 February 2021
The University of Oxford, together with three partner sites in London, Southampton and Bristol, is to launch the first study to assess the safety and immune responses in children and young adults of the ChAdOx1 nCoV-19 coronavirus vaccine.
Exscientia and the University of Oxford announce partnership to develop treatments for Alzheimer’s disease
General Research
12 February 2021
Neuroinflammation collaboration targeting inflammasome steps-up-the-pace in race for Alzheimer’s disease medicines that alleviate the burden of devastating disease
Tocilizumab reduces deaths in patients hospitalised with COVID-19
Coronavirus COVID-19 General Research
11 February 2021
The Randomised Evaluation of COVID-19 Therapy (RECOVERY) has demonstrated that an anti-inflammatory treatment, tocilizumab, reduces the risk of death when given to hospitalised patients with severe COVID-19. The study also showed that tocilizumab shortens the time until patients are successfully discharged from hospital and reduces the need for a mechanical ventilator.
Study reveals the safety of bisphosphonates in chronic kidney disease
General Research
10 February 2021
The results of an observational study published in JMBR and funded by the Health Technology Assessment Programme shows that bisphosphonate use is associated with a greater risk of chronic kidney disease progression.
Drug trial that could improve respiratory recovery from COVID-19 now underway
Clinical Trials Coronavirus COVID-19 General
10 February 2021
A clinical trial has commenced this week to test whether a drug called Almitrine can help people who are seriously ill with COVID-19 to recover from the disease.
WHiTE Four trial results published
General Research
9 February 2021
The results of the WHiTE Four clinical trial for the treatment of fragility hip fractures have been published in The Bone and Joint Journal.
Common asthma treatment reduces need for hospitalisation in COVID-19 patients, study suggests
Coronavirus COVID-19 General Research
9 February 2021
Early treatment with a medication commonly used to treat asthma appears to significantly reduce the need for urgent care and hospitalisation in people with COVID-19, researchers at the University of Oxford have found.
NHS COVID-19 contact tracing app averted between 200,000 and 900,000 infections, estimates infectious disease experts
Coronavirus COVID-19 General Research
9 February 2021
A team of medical research and statistical modelling experts at Oxford University and the Alan Turing Institute have conducted a joint analysis to assess the impact of the NHS COVID-19 contact tracing app.
Travels with Vignesh
General Staff and student stories
9 February 2021
Vignesh Murugesan, a Postdoctoral Researcher in Department of Physiology, Anatomy & Genetics (DPAG), describes how he found his way from the large metropolitan town of Chennai in India to studying regenerative medicine here in Oxford, via an 8 year stint in Sweden.
ChAdOx1 nCov-19 provides minimal protection against mild-moderate COVID-19 infection from B.1.351 coronavirus variant in young South African adults
Clinical Trials Coronavirus COVID-19 General
8 February 2021
In an analysis, submitted as a pre-print prior to peer-review publication, a two-dose regimen of the ChAdOx1 nCoV-19 vaccine provides minimal protection against mild-moderate COVID-19 infection from the B.1.351 coronavirus variant first identified in South Africa.
New machine learning system developed to identify deteriorating patients in hospital
General Research
5 February 2021
Researchers have developed a machine learning algorithm that could improve clinicians’ ability to identify hospitalised patients who need intensive care.
Oxford vaccine effective against major B.1.1.7 ‘Kent’ coronavirus strain circulating in the UK
Clinical Trials Coronavirus COVID-19 General
5 February 2021
A preprint of ongoing work to assess effectiveness of Oxford’s ChAdOx1 coronavirus vaccine shows that the existing vaccine has similar efficacy against the B.1.1.7 ‘Kent’ coronavirus strain currently circulating in the UK to previously circulating variants.
Vascular loss shown to be the primary hallmark of ageing
General Research
4 February 2021
New research from the Kennedy Institute of Rheumatology (Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences) identifies vascular attrition, marked by pericyte to fibroblast differentiation, as a primary hallmark of ageing and highlights organ-specific vascular changes with age.
New reporting guidelines to bridge the gap from development to implementation in clinical artificial intelligence
General Research
4 February 2021
In a correspondence to Nature Medicine, a team of Oxford-led academics describe upcoming new guidelines to improve the reporting of early clinical stage (or first-with-human) evaluation of decision support systems driven by artificial intelligence.
BioEscalator’s Enara Bio partners with Boehringer Ingelheim to develop novel cancer immunotherapies
General Innovation
4 February 2021
Enara Bio, a start-up located in the University’s BioEsclator, has announced a strategic collaboration and licensing agreement with Boehringer Ingelheim, worth over €876M (£787M), to lead the discovery and validation of Dark Antigens to target lung and gastrointestinal cancers.
Oxford leads first trial investigating dosing with alternating vaccines
Clinical Trials Coronavirus COVID-19 General
4 February 2021
The University of Oxford is to lead the first trial to explore alternating different COVID-19 vaccines, to explore the potential for flexibility in delivery and look for clues as to how to increase the breadth of protection against new virus strains.
MSD projects awarded Public Engagement Seed Funding 2020-21
General Public Engagement with Research
3 February 2021
Seven projects from the Medical Sciences Division have received funding in the 2020-21 round of the Public Engagement with Research Seed Fund for innovative projects to engage the public with medical research.
Understanding the first wave of COVID-19 and implications for tackling the ongoing pandemic: evidence from 5.5 million people from Catalonia, Spain
Coronavirus COVID-19 General Research
3 February 2021
Health outcomes during the first wave of COVID-19 in Catalonia, Spain, have been described in detail in a study published by Nature Communications.
Oxford coronavirus vaccine shows sustained protection of 76% during the 3-month interval until the second dose
Clinical Trials Coronavirus COVID-19 General Research
2 February 2021
Researchers at the University of Oxford have today published in Preprints with The Lancet an analysis of further data from the ongoing trials of the vaccine. In this, they reveal that the vaccine efficacy is higher at longer prime-boost intervals, and that a single dose of the vaccine is 76% effective from 22- to up to 90-days post vaccination.