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An internationally recognised centre of excellence for biomedical and clinical research and teaching
How monkeys and humans make novel choices
General Research
15 February 2021
Dr Alessandro Bongioanni, Postdoctoral Research Associate in the Department of Experimental Psychology, writes for the Oxford Science Blog on the way humans and other primates make first-time choices.
Exscientia and the University of Oxford announce partnership to develop treatments for Alzheimer’s disease
General Research
12 February 2021
Neuroinflammation collaboration targeting inflammasome steps-up-the-pace in race for Alzheimer’s disease medicines that alleviate the burden of devastating disease
Tocilizumab reduces deaths in patients hospitalised with COVID-19
Coronavirus COVID-19 General Research
11 February 2021
The Randomised Evaluation of COVID-19 Therapy (RECOVERY) has demonstrated that an anti-inflammatory treatment, tocilizumab, reduces the risk of death when given to hospitalised patients with severe COVID-19. The study also showed that tocilizumab shortens the time until patients are successfully discharged from hospital and reduces the need for a mechanical ventilator.
Study reveals the safety of bisphosphonates in chronic kidney disease
General Research
10 February 2021
The results of an observational study published in JMBR and funded by the Health Technology Assessment Programme shows that bisphosphonate use is associated with a greater risk of chronic kidney disease progression.
WHiTE Four trial results published
General Research
9 February 2021
The results of the WHiTE Four clinical trial for the treatment of fragility hip fractures have been published in The Bone and Joint Journal.
Common asthma treatment reduces need for hospitalisation in COVID-19 patients, study suggests
Coronavirus COVID-19 General Research
9 February 2021
Early treatment with a medication commonly used to treat asthma appears to significantly reduce the need for urgent care and hospitalisation in people with COVID-19, researchers at the University of Oxford have found.
NHS COVID-19 contact tracing app averted between 200,000 and 900,000 infections, estimates infectious disease experts
Coronavirus COVID-19 General Research
9 February 2021
A team of medical research and statistical modelling experts at Oxford University and the Alan Turing Institute have conducted a joint analysis to assess the impact of the NHS COVID-19 contact tracing app.
New machine learning system developed to identify deteriorating patients in hospital
General Research
5 February 2021
Researchers have developed a machine learning algorithm that could improve clinicians’ ability to identify hospitalised patients who need intensive care.
Vascular loss shown to be the primary hallmark of ageing
General Research
4 February 2021
New research from the Kennedy Institute of Rheumatology (Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences) identifies vascular attrition, marked by pericyte to fibroblast differentiation, as a primary hallmark of ageing and highlights organ-specific vascular changes with age.
New reporting guidelines to bridge the gap from development to implementation in clinical artificial intelligence
General Research
4 February 2021
In a correspondence to Nature Medicine, a team of Oxford-led academics describe upcoming new guidelines to improve the reporting of early clinical stage (or first-with-human) evaluation of decision support systems driven by artificial intelligence.
Understanding the first wave of COVID-19 and implications for tackling the ongoing pandemic: evidence from 5.5 million people from Catalonia, Spain
Coronavirus COVID-19 General Research
3 February 2021
Health outcomes during the first wave of COVID-19 in Catalonia, Spain, have been described in detail in a study published by Nature Communications.
Oxford coronavirus vaccine shows sustained protection of 76% during the 3-month interval until the second dose
Clinical Trials Coronavirus COVID-19 General Research
2 February 2021
Researchers at the University of Oxford have today published in Preprints with The Lancet an analysis of further data from the ongoing trials of the vaccine. In this, they reveal that the vaccine efficacy is higher at longer prime-boost intervals, and that a single dose of the vaccine is 76% effective from 22- to up to 90-days post vaccination.
Same genome, different worlds: How a similar brain causes sexually dimorphic behaviours
General Research
27 January 2021
A new paper from Department of Physiology, Anatomy & Genetics's Centre for Neural Circuits and Behaviour has shown how males and females are programmed differently in terms of sex.
New form of gift wrap drives male reproductive success
General Research
26 January 2021
A study from the Department of Physiology, Anatomy and Genetics (DPAG) has identified a new communication mechanism that ensures the transfer of a complex mix of signals and nutrients required for successful reproduction between males and females.
PRINCIPLE trial finds antibiotics azithromycin and doxycycline not generally effective treatments for COVID-19
Coronavirus COVID-19 General Research
25 January 2021
In March 2020, the UK-wide Platform Randomised trial of INterventions against COVID-19 In older people (PRINCIPLE) trial was established as a flexible, platform randomised clinical trial to test a range of potential treatments for COVID-19 that might be suitable for use in the community to help people recover more quickly and prevent the need for hospital admission. The trial is one of three national platform trials for COVID-19 treatments, and complements the RECOVERY and REMAP-CAP trials that focus on hospitalised patients.
Early animal studies yield promising results for new potential COVID-19 vaccine
Coronavirus COVID-19 General Research
25 January 2021
Studies carried out in the MRC Human Immunology Unit (MRC HIU) in collaboration with the Pirbright Institute have shown that a new potential vaccine against COVID-19, named RBD-SpyVLP, produces a strong antibody response in mice and pigs, providing vital information for the further development of the vaccine. Although this type of vaccine is not a competitor for the first wave of vaccines, it is hoped that it will be useful as a standalone vaccine or as a booster for individuals primed with a different COVID-19 vaccine.
Just over half of British Indians would take COVID vaccine
Coronavirus COVID-19 General Research
21 January 2021
University of Oxford researchers from the Department of Physiology, Anatomy and Genetics (DPAG) and the Department of Psychiatry, in collaboration with The 1928 Institute, have published a major new study on the impact of COVID-19 on the UK’s largest BME population.
Investigating New Treatment for Schizophrenia
General Innovation Research
21 January 2021
A partnership between University of Oxford, the Earlham Institute, and the global pharmaceutical companies Biogen Inc and Boehringer Ingelheim is announced today to investigate a new drug target for the treatment of schizophrenia.
Joggers and cyclists should wear masks – here’s why
Coronavirus COVID-19 General Research
19 January 2021
Parental mental health worsens under new national COVID-19 restrictions
Coronavirus COVID-19 General Research
19 January 2021
Parental stress, depression and anxiety have again increased since new national restrictions have been introduced, according to the latest report from the Oxford University-led COVID-19 Supporting Parents, Adolescents, and Children in Epidemics (Co-SPACE) study, based on data from over 6000 UK parents.