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An internationally recognised centre of excellence for biomedical and clinical research and teaching

New ultrasound drug delivery system found to be highly effective against bacterial biofilms

Researchers at the University of Oxford have developed a new drug delivery system using ultrasound-activated nanoparticles to break through and destroy bacterial biofilms. This offers a promising solution that could address the global crisis of chronic antibiotic-resistant infections affecting hundreds of millions of people worldwide.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) leads study on burosumab for adults with rare inherited disorder

NDORMS researchers have been awarded funding to explore the long-term effects of burosumab in adults with X-linked hypophosphataemia (XLH).

Study identifies direct link between inflammation and asthma attacks

An international consortium of respiratory scientists, including researchers from the Nuffield Department of Medicine’s Experimental Medicine Division, have shed light on the role of inflammation in asthma. Through their findings, they have provided a new way of predicting and preventing asthma attacks.

Addressing healthcare workforce challenges with new research partnership

Researchers from the Nuffield Department of Primary Care Health Sciences are part of a major new research initiative aimed at tackling critical workforce challenges in healthcare, particularly in underserved communities.

Up to £16.5 million awarded to global consortium to overcome obstacles in infectious disease research

The International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) has been awarded up to £16.5 million to build on its globally-recognised efforts to prevent illness and deaths from epidemic-prone infectious diseases.

Blood cancer patients should continue treatment at time of COVID-19 vaccination, Oxford Clinical Trials Research Unit study shows

Evidence shows for patients with a type of leukaemia, pausing BTKi therapy for COVID-19 vaccination does not improve antibody responses to the vaccine

Boosting vaccines with harmless bacteria to fight intestinal pathogens

Published in Science, a ground-breaking study by the Slack group reveals how combining vaccines with friendly bacteria can boost vaccination efficacy and potentially reduce reliance on antibiotics.

The Kenya Medical Research Institute (KEMRI) signs landmark partnership with Wellcome and Oxford

The Kenya Medical Research Institute (KEMRI) has officially entered into a seven-year Memorandum of Understanding (MoU) with Wellcome, a UK-based charitable foundation, and the University of Oxford. The £91 million agreement was signed at the Wellcome headquarters in London, marking a significant boost for medical research and training in Kenya.

New international guidelines for the treatment of schizophrenia

Researchers from all regions of the UN have developed a set of consensus guidelines for the treatment of schizophrenia.

Study reveals one in ten people feel NHS has caused them harm

One in ten people surveyed reported that the NHS has caused them physical or emotional harm, according to a new study by researchers at Oxford Population Health and the London School of Hygiene & Tropical Medicine (LSHTM). The study is published in BMJ Quality & Safety.

New paper on sleep published in Current Biology by members of the Vyazovskiy Group and colleagues

This study reports novel fundings from a mouse model called rlss (for restless) of deficient synaptic neurotransmission, that results from a mutation in one of the key SNARE proteins VAMP2.

New study finds an epilepsy drug could be effective for people with depression

A recent study has investigated whether ezogabine, an anticonvulsant drug given to people with epilepsy, is affective for people with depression.

Translational Health Sciences academics co-authoring crucial sustainable health care book

The climate crisis is reshaping every aspect of our world, including health care. While health systems are designed to protect and improve lives, they also contribute significantly to environmental degradation through greenhouse gas emissions, waste and pollution, and unsustainable supply chains. How can we transform health care to operate within planetary limits while maintaining fairness, equity, and optimal patient outcomes?

Landmark study finds no benefit of routine use of cerebral embolic protection devices on TAVI stroke risk

Researchers say the devices cannot be recommended for routine clinical use in the UK.

£5.5M Research funding to transform bowel cancer care

Cancer Research UK and partners have today committed £5.5m in funding to form a world-leading research team tasked with making personalised medicine a reality for people with bowel cancer. The team will be co-led by Professor Simon Leedham from the Nuffield Department of Medicine at the University of Oxford.

New research uncovers pathways to prevent premature cell death

New research from the Kennedy Institute has revealed how two important proteins, TBK1 and IKKe, play a crucial role in preventing premature cell death, which can lead to serious inflammation in the body. The findings are particularly relevant for people with a mutation in the TBK1 gene who often develop multiorgan inflammation caused by excessive cell death even in the absence of any infection.

Making medical research work where it matters most: Global team calls for revolution in GP and community health and care trials

An international team, led the Nuffield Department of Primary Care Health Sciences, is calling for a fundamental shift in how we conduct health research to better serve our real-world health and care needs.

Oxford launches first human trial of aerosol vaccine delivery

The University of Oxford in partnership with the Coler Lab at Seattle Children’s Research Institute (SCRI) has begun a new clinical trial called TB045, which aims to test tuberculosis (TB) vaccine safety and the host immune response in a first-in-human aerosol mycobacterial challenge infection model with healthy adult volunteers.

Daily physical activity, even at light intensities, linked to lower cancer risk

A study led by researchers from Oxford Population Health has found that daily physical activity is linked to a lower risk of cancer. The number of steps taken daily may be more important for cancer risk than the intensity of activity.

One-third of antibiotics used in Vietnam are ‘inappropriate’

Ranking 11th globally in antibiotic use, Vietnam faces a serious risk of drug resistance, and could be ‘running out of treatment options due to antibiotic resistance’.

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