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Researchers in the Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences (NDORMS) reveal supramolecular attack particles are autonomous killing entities released from cytotoxic T lymphocytes

Cryo-soft-x-ray tomography projection of a CD8+ T cell interacting (right)
Cryo-soft-x-ray tomography projection of a CD8+ T cell interacting with a carbon coated EM grid containing ICAM-1 and anti-CD3e (left). SMAPs (middle) can be observed within the multicore granules inside the cell. dSTORM images of an individual SMAP positive for perforin (green), WGA (orange) and granzyme B (magenta) released by CD8+ T cells (right)

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