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An internationally recognised centre of excellence for biomedical and clinical research and teaching
Determining the atomic structure of bacterial surface proteins in situ
General Research
14 January 2020
Researchers in the Sir William Dunn School of Pathology, together with colleagues from across Oxford, have successfully obtained a structure of the surface layer from Gram-negative bacteria, bound to the cell membrane via long sugars called lipopolysaccharide or endotoxin, by applying novel electron tomography techniques.
New target identified to help prevent dangerous heart rhythms after heart attack
General Research
9 January 2020
For many years, we have been using beta-blockers to neutralise a specific stress hormone and prevent dangerous heart rhythms following a heart attack. However, a new study led Department of Physiology, Anatomy & Genetics (DPAG) and published in the European Heart Journal has uncovered evidence for an additional stress hormone acting as a key trigger for dangerous heart rhythms that is not currently targeted by these drugs.
Removing body clock gene protects mice against pneumonia
General Research
9 January 2020
Removing the clock gene BMAL1 makes bacteria-engulfing defence cells in the body more effective, a new study from the Radcliffe Department of Medicine has found.
Biomarker predicts which patients with heart failure have a higher risk of dying
General Research
8 January 2020
UCLA researchers in collaboration with Department of Physiology, Anatomy & Genetics researchers have identified a biomarker for increased risk of early mortality in patients with heart failure. Associate Professor Neil Herring is senior author.
Mobile Malaria Project team begin their journey
Research
1 April 2019
The Mobile Malaria Project team, led by Dr George Busby from University of Oxford, will travel over 6,300km across Namibia, Zambia, Tanzania and Kenya to investigate the challenges facing those on the front line of malaria control in Africa – where 90 per cent of the world’s cases occur.
Vaccine developed to treat osteoarthritic pain
General Research
13 March 2019
Researchers have developed a vaccine that blocks the effects of the main cause of pain in osteoarthritis (OA) - nerve growth factor (NGF) – in mice.
Scientists catch heartbeat ‘molecular switch’ in action
General Research
8 February 2019
Oxford University Radcliffe Department of Medicine researchers have developed a new method that uses a protein originally found in marine corals to visualise the flow of calcium that makes the heart beat.
10-Year Partnership with GenesisCare
General Innovation Research
7 February 2019
GenesisCare and the University of Oxford establish innovative 10-year research partnership to improve diagnosis and care for people with cancer.
Ten-year outcomes of cardiac surgery trial published
General Research
6 February 2019
The ten-year outcomes of the Arterial Revascularisation Trial (ART), conducted by the Nuffield Department of Surgical Sciences (NDS), have been published in the New England Journal of Medicine.
New grant from Cancer Research UK will help develop early detection methods for Oesophageal cancer
Awards and Appointments Research
6 February 2019
Researchers from Department of Physiology, Anatomy & Genetics and Nuffield Department of Clinical Medicine have been awarded a Cancer Research UK Primer grant of £100,000 to study biomarkers for non-invasive early detection of oesophageal adencarcinoma.
People with chronic conditions are missing out on health management benefits of physical activity
General Research
5 February 2019
A study of over 96,000 UK men and women, of average age 64.5 years, has found that those with chronic conditions are spending considerably less time on physical activity than their healthy peers, so are missing out on its health management benefits.
BDI to host EPSRC Centre for Doctoral Training in Health Data Science
Awards and Appointments Research
5 February 2019
The Engineering and Physical Sciences Research Council (EPSRC) has funded a new Centre for Doctoral Training (CDT) in Health Data Science at the University of Oxford. The Centre will be located within the Big Data Institute, and will play a leading role in training the next generation of health data scientists.
Fundamental advances in vascular development knowledge
Research
4 February 2019
Research carried out by the Department of Physiology, Anatomy & Genetics represents advances in vascular development knowledge.
MRI scans reveal how brain protects memories
Research
4 February 2019
Research by the Wellcome Centre for Integrative Neuroimaging has identified two distinct parts of the human brain - the neocortex and the hippocampus (a part of the brain involved in higher-order brain functions) - which protect our memories from interfering with one another.
Natural Killer cells used to treat chronic pain by removing damaged nerves after injury
Research
4 February 2019
An international collaboration of scientists, led by Alexander Davies and Simon Rinaldi from the Nuffield Department of Clinical Neurosciences, has found that specialised cells within the body’s immune system - Natural Killer cells - play a significant role in removing damaged nerve fibres.
Oxford University signs universal flu vaccine development deal with US startup BWV
Innovation Research
4 February 2019
Oxford University, through its innovation arm Oxford University Innovation (OUI), has entered into an option agreement for a universal influenza vaccine with US-based startup Blue Water Vaccines (BWV), which is raising $15m to support development of the flu shot.
Bad brakes
Research
4 February 2019
Researchers in the Radcliffe Department of Medicine identify a faulty molecular brake that interferes with heart muscle’s ability to contract and relax
Statin therapy reduces cardiovascular disease risk in older people
General Research
1 February 2019
Statin therapy reduces major vascular events, such as heart attacks and strokes, in people of all ages, including those over the age of 75, according to a new study published in The Lancet.
Innovations get £3M boost to prove the potential of health data to transform lives
Awards and Appointments General Innovation Research
1 February 2019
Ten innovative data solutions to healthcare challenges, including a project led by the Head of the Nuffield Department of Surgical Sciences (NDS), Professor Freddie Hamdy, are set to receive a share of £3 million Government funding following a UK-wide competition. The initiatives will see NHS, universities and companies combining expertise and using health data responsibly to drive innovation and improve health outcomes for people across the UK.