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An internationally recognised centre of excellence for biomedical and clinical research and teaching

Study reveals liver problems may drive DNA build-up in sepsis patients

Researchers at NDM’s Centre for Human Genetics have discovered that cell-free DNA builds up in the blood of patients with sepsis because of impaired liver clearance. These findings show that investigating cell-free DNA could be a powerful tool for monitoring what happens in the body during sepsis.

Continuing hormone treatment with aromatase inhibitors beyond five years further reduces the risk of breast cancer recurrence by a quarter in postmenopausal women

Continuing treatment with aromatase inhibitors (a type of hormone therapy) for another five years further reduces the risk of developing secondary breast cancer by over a quarter for certain women. These results from the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), based at Oxford Population Health, are published in The Lancet.

Scientists create first atlas showing cell interaction in lung fibrosis

In a collaborative new study, researchers have developed the first mathematically supported cellular map of lung tissue in idiopathic pulmonary fibrosis and uncovered key immune cell interactions that could explain why lungs fail to repair in this deadly disease with no known cure.

New research highlights need for global action to tackle noma disease

A new paper conducted by the Infectious Disease Data Observatory and the World Health Organization has revealed major gaps in research on noma, a severe and often fatal oral disease affecting children in low-resource settings. The review analysed 366 studies to provide a comprehensive foundation for future research and policy action.

£27 million gift funds new Oxford Centre for Emerging Minds Research focused on young people’s mental health

A pioneering research centre aimed at achieving better mental health outcomes for children, young people and families will be established at the University of Oxford thanks to a £27 million gift from The Paul Foundation.

The World Health Organization (WHO) Collaborating Centre for Genomic Surveillance of AMR launched

Hosted by the Centre for Genomic Pathogen Surveillance at PSI, the new Centre will support efforts to tackle one of the most pressing global health challenges of our time - antimicrobial resistance.

Malaria parasite found to hijack human immune system

Oxford researchers have unveiled new insights into the ongoing evolutionary battle between humans and the malaria parasite. The international team has discovered how the malaria parasite evades the immune system—and how the human body fights back.

Prehistoric teeth used to create historic map of infectious diseases

A research project led jointly by researchers from the University of Oxford, the University of Copenhagen and University of Cambridge shows that large-scale mapping of prehistoric teeth and bones provides new knowledge of present-day infectious diseases. This may, among other things, have an impact on the development of vaccines.

The Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) recognised as a European Centre of Excellence

NDORMS has been awarded the designation of a EULAR Centre of Excellence for a third consecutive term. This prestigious award is a recognition of the department’s contribution to advancing the science of rheumatic and musculoskeletal diseases.

Oxford University Chancellor Lord Hague visits Nuffield Department of Primary Care Health Sciences

Lord Hague, Chancellor of Oxford University, visited the Nuffield Department of Primary Care Health Sciences (NDPCHS) to explore how its research and teaching are addressing urgent health challenges in the UK and globally.

AMR surveillance project in Nigeria delivers life-saving impacts

A research project led by the Ineos Oxford Institute for antimicrobial research (IOI) to study the cause and impact of antimicrobial-resistant sepsis in Nigeria has resulted in reduced new-born deaths, improved awareness about neonatal infection prevention amongst parents, and strengthened capacity and training for local doctors. The findings have been published in Nature Communications.

Identifying research priorities for severe paranoia

We talk to lead author David Sher about his paper, which aimed to establish potential research priorities for understanding and treating severe paranoia for the first time.

New Global Health Building reaches its highest point

A topping-out ceremony has taken place at the Old Road Campus to mark the completion of the main structure of the University’s new Global Health Building

Babies made using three people's DNA are born free of hereditary disease

Eight babies born free of hereditary disease using DNA from three people.

Scientists reveal how cells repair toxic DNA damage linked to cancer and premature ageing

Researchers at the University of Oxford and Nanyang Technological University, Singapore have uncovered the mechanism by which cells identify and repair a highly toxic form of DNA damage that causes cancer, neurodegeneration, and premature ageing.

New research finds that ivermectin could help control malaria transmission

A collaborative new study involving KEMRI-Wellcome Trust researchers has highlighted a new way to control malaria transmission. The study found that ivermectin, a drug normally used for neglected tropical diseases, led to a 26% reduction in new malaria infections among children aged 5-15.

Immune cells show promise in treating hypertrophic cardiomyopathy

A new study from scientists at the Radcliffe Department of Medicine and Harvard Medical School, and funded by the British Heart Foundation, has uncovered a potential new treatment for hypertrophic cardiomyopathy (HCM).

Why do we need sleep? Oxford researchers find the answer may lie in mitochondria

New study uncovers how a metabolic “overload” in specialised brain cells triggers the need to sleep.

Certain chronic health conditions associated with increased risk of dementia – new study

Developing cardiovascular, mental health and neurological-related illnesses before the age of 70 is associated with a greater risk of dementia later in life, with the more of these conditions accumulated the greater the risk, according to a new study by the University of Oxford.

New £50m MRC Centre launched to study how environmental exposures cause chronic inflammatory diseases

A new Medical Research Council Centre of Research Excellence (MRC CoRE) will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases, such as asthma, chronic obstructive pulmonary disorder (COPD) and inflammatory bowel disease (IBD).

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