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An internationally recognised centre of excellence for biomedical and clinical research and teaching
Young lives under pressure as global crises hits mental health and well-being – report
25 November 2022
The well-being and mental health of young people in low - and middle - income countries have been dramatically affected by the series of crises hitting the world. As the international community continues to struggle with the impact of COVID-19, conflict and climate change, the latest report from the Young Lives project shows a long-running upward trend in young people’s well-being has been sharply reversed alongside widespread anxiety and depression. Young people are less confident about their futures for the first time in the 20-year study.
Bacterial infections linked to one in eight global deaths, according to GRAM study
23 November 2022
Data showing 7.7 million deaths from 33 bacterial infections can guide measures to strengthen health systems, particularly in low-income settings
First evidence drug resistant bacteria can travel from gut to lung, increasing infection risks
22 November 2022
A new Oxford University study released during World Antimicrobial Awareness Week has significant findings on how antimicrobial resistance (AMR) arises and persists. The results, published today in Nature Communications, provide the first direct evidence of AMR bacteria migrating from a patient’s gut microbiome to the lungs, increasing the risk of deadly infections.
Many adolescents game a lot without negative effects on their wellbeing
21 November 2022
A new study published by University of Oxford researchers in an open-access journal, JMIR Pediatrics and Parenting, shows that although many school-age adolescents are spending considerable time gaming, it is not having a negative impact on the wellbeing.
Oxford’s Ebola vaccine recommended for deployment against Uganda outbreak
18 November 2022
A vaccine developed by the Oxford Vaccine Group’s Prof Teresa Lambe and supported in clinical trials and manufacture scale-up by researchers from the Jenner Institute (Nuffield Department of Medicine) has been recommended for inclusion in a ring vaccination trial to combat a Sudan ebolavirus outbreak in Uganda.
E-cigarettes are more effective than nicotine-replacement therapy in helping smokers quit
17 November 2022
The latest Cochrane Review finds high certainty evidence that nicotine e-cigarettes are more effective than traditional nicotine-replacement therapy (NRT) in helping people quit smoking.
Researchers make miniature ‘bone marrows in a dish’ to improve anti-cancer treatments
16 November 2022
Scientists from Oxford University and the University of Birmingham have made the first bone marrow ‘organoids’ that include all the key components of human marrow. This technology allows for the screening of multiple anti-cancer drugs at the same time, as well as testing personalised treatments for individual cancer patients.
Key cause of type 2 diabetes uncovered
14 November 2022
Oxford research reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes.
New study shows clinical symptoms for Alzheimer’s can be predicted in preclinical models
10 November 2022
Establishing preclinical models of Alzheimer’s that reflect in-life clinical symptoms of each individual is a critically important goal, yet so far it has not been fully realised. A new collaborative study from the University of Oxford has demonstrated that clinical vulnerability to an abnormally abundant protein in Alzheimer’s brain is in fact reflected in individual patient induced pluripotent stem cell-derived cortical neurons.
New tool could help GPs predict and prevent serious falls
8 November 2022
Researchers, led by the Nuffield Department of Primary Care Health Sciences, University of Oxford, have developed a new tool for doctors to identify patients at high risk of serious falls. The tool could have a big impact on the way older patients are managed in primary care, improving targeting of drug treatment and fall prevention strategies for high-risk individuals.
Profiling the entire cancer genome identifies new subgroups of blood cancer
7 November 2022
The University of Oxford has led the largest and most comprehensive analysis of the entire genomic landscape of the commonest type of blood cancer called chronic lymphocytic leukaemia (CLL) as part of the UK’s 100,000 Genomes Project. This work defines five genomic subgroups of CLL and associates these with clinical outcomes, and these subgroups provide a better estimation of patient prognosis than achieved by previous single gene analyses, allowing more tailored patient care.
University of Oxford study provides important insights into TB correlates of protection
7 November 2022
Researchers from the University of Oxford have today reported findings from a study that investigated whether previously identified correlates of protection associated with risk of full-blown tuberculosis (TB) disease could also be associated with risk of infection from the bacteria that causes TB - highlighting certain correlates in the process.
Therapeutic HIV vaccine with Oxford technology achieves encouraging results
4 November 2022
A phase I/IIa clinical trial that the University of Oxford collaborated on has demonstrated that a T-cell therapeutic HIV vaccine was associated with better control of the virus rebound when antiretroviral therapy (ART) was temporarily withdrawn.
Bacterial armour plating has implications for antibiotics
3 November 2022
A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armour, which has far-reaching implications for the development of antibiotics.
Pancreatic cancer could be diagnosed up to three years earlier
2 November 2022
Pancreatic cancer could be identified in patients up to three years earlier than current diagnoses, new research suggests. Weight loss and increasing blood glucose levels are early indicators of pancreatic cancer and could lead to a more timely diagnosis, helping to improve survival rates.
Study reveals new evidence on rare blood-clotting condition after covid-19 vaccination
28 October 2022
Researchers from Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences (NDORMS) at the University of Oxford have investigated claims that some adenovirus-based COVID-19 vaccines increase the risk of rare blood clots compared to their mRNA-based counterparts.
Oxford contributes to new UK research consortium to tackle monkeypox
26 October 2022
The UK’s efforts to tackle the monkeypox outbreak will receive a huge boost with the creation of a new research consortium – in which the University of Oxford is a key partner – working together to develop better diagnostic tests, identify potential therapies and study vaccine effectiveness.
Food industry shows ‘stalled progress’ to reduce salt intakes, new Oxford-led analysis finds
20 October 2022
New research led from the Nuffield Department of Primary Care Health Sciences has shown that, overall, the average salt content of food products sold at supermarkets has not changed between 2015 and 2020. The results also showed that for certain products (ready meals, pizzas and soups) the volume of salt sold increased during this time.