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An internationally recognised centre of excellence for biomedical and clinical research and teaching

New research improves accuracy of molecular quantification in high throughput sequencing

A team at Nuffield Department of Orthopaedic Rheumatology and Musculoskeletal Sciences (NDORMS) has developed a new approach to significantly improve the accuracy of Ribonucleic acid (RNA) sequencing. They pinpoint the primary source of inaccurate quantification in both short and long-read RNA sequencing, and have introduced the concept of “majority vote” error correction leading to a substantial improvement in RNA molecular counting.

World Cancer Day 2024: Highlighting Cancer Research at the Medical Research Council Weatherall Institute of Molecular Medicine (MRC WIMM)

This World Cancer Day, we heard from four Group Leaders at the MRC Weatherall Institute of Molecular Medicine about their work and how their groups are helping in the fight against cancer.

New phase 3 trial data confirm the uniquely high efficacy and good safety profile of the R21/Matrix-M malaria vaccine in African children

Investigators immunised over 4800 young children in a trial in Burkina Faso, Kenya, Mali and Tanzania and found on average 78% efficacy in the 5–17-month age group over the first year To date 25 million doses manufactured and ready for roll-out by The Serum Institute of India (SII) in the next three to four months

New data shows prevalence of Premenstrual Dysphoric Disorder

Around 1.6% of women and girls have symptomatic Premenstrual Dysphoric Disorder (PMDD), according to a new review of global studies published in the Journal of Affective Disorders.

New guidance published to aid researchers evaluating surgical robots

Surgical robotics are amongst the most complex devices entering healthcare, but how should we evaluate them? Published in Nature Medicine, the Idea, Development, Exploration, Assessment and Long-term monitoring (IDEAL) Robotics Colloquium outlines the latest guidance to aid researchers evaluating surgical robots.

Researchers develop easy-to-deploy federated learning system that safeguards patient data

Researchers in Oxford have developed a new, easy-to-use technique for hospitals to contribute to the development of artificial intelligence (AI) models, without patient data leaving the hospital’s premises.

Study assesses long-term risk of invasive breast cancer after pre-invasive disease

Women who are diagnosed with ductal carcinoma in situ (DCIS) outside the National Health Service breast screening programme are around four times as likely to develop invasive breast cancer and to die from breast cancer than women in the general population, finds a University of Oxford study published by the British Medical Journal (BMJ)

New reporting guideline will provide transparency in consensus research

Published in The Public Library of Science (PLOS), the new guideline will help the scientific community to write complete and transparent research reports involving consensus methods.

Using Innovation Enhancing Techniques (IETs) as a framework for creative solutions

Medical student, Anuraag Vazirani, and fellow colleagues from St Cross College, recently published a paper in the journal Scientific Reports, in which they introduce Innovation Enhancing Techniques (IETs) to address challenges in healthcare and biomedicine, offering a versatile framework for creative solutions. Their study aims to give entrepreneurs, innovators, and researchers a toolkit to create innovative solutions to problems they are trying to solve.

Research uncovers mechanism behind stubborn memories

Researchers from the Medical Research Council Brain Network Dynamics Unit at the University of Oxford and the Nuffield Department of Clinical Neurosciences have identified a novel mechanism by which the brain produces powerful lasting memories that drive ill-advised actions.

Innovative Imaging solution offers potential breakthrough in endometriosis detection

The DETECT study, led by Nuffield Department of Women's and Reproductive Health Professors Christian Becker and Krina Zondervan explores the potential of visualizing endometriosis, including hard-to-detect superficial peritoneal disease, using Serac's innovative imaging agent.

Study highlights importance of ‘junk’ DNA in unlocking diagnosis

A recent study led by the Centre for Human Genetics at the Nuffield Department of Medicine has revealed that areas of the human genome that are routinely overlooked in clinical tests may be the cause of some rare diseases.

Lymph node research pioneers’ new approach to vaccine design for the most vulnerable

The Oxford Experimental Medicine Clinical Research Facility (EMCRF) at Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) has received its first volunteers as part of the LEGACY03 trial to improve vaccine design for different age groups.

Novel inhaled TB vaccine

The Jenner Institute is conducting a new study, using BCG, the current licensed vaccine against tuberculosis. In this study, they will give BCG a second time to people who have already had BCG once before, and will compare whether giving it by inhalation is better at protecting people against tuberculosis than giving it into the skin

First-in-human vaccine trial for deadly Nipah virus launched

First clinical trial participants received doses of the ChAdOx1 NipahB vaccine over the last week at University of Oxford. UK trial is first step to developing a vaccine against Nipah virus – a devastating disease mostly found in South-East Asia – that can be fatal in up to 75% of cases. The milestone clinical trial comes as the global health community marks the 25th anniversary of the first Nipah virus outbreaks. There are still no approved vaccines or treatments for the disease.

COVID-19 vaccines found effective in reducing long COVID symptoms

A recent study has revealed the effectiveness of COVID-19 vaccines in preventing long COVID

Research into ancient DNA sheds new light on cause of Multiple Sclerosis and other neurodegenerative diseases

Research led by scientists at the Universities of Oxford, Cambridge, Copenhagen, Bristol and California (Berkeley) reveals the evolutionary origins of multiple sclerosis (MS). This new insight into the genetic architecture of this disease changes scientists’ view of its causes and has implications for its treatment, as well as paving the way for further investigations into other diseases.

Study shows that the way the brain learns is different from the way that artificial intelligence systems learn

Researchers from the MRC Brain Network Dynamics Unit and Oxford University’s Department of Computer Science have set out a new principle to explain how the brain adjusts connections between neurons during learning. This new insight may guide further research on learning in brain networks and may inspire faster and more robust learning algorithms in artificial intelligence.

What is selective mutism? And is it a lifelong condition?

Selective mutism is an anxiety disorder characterised by a consistent pattern of silence in specific social situations where speech is expected (for example, at school or work) while the person is able to speak comfortably in other situations.

Early-life diseases linked to lifelong childlessness

A ground-breaking study, published in Nature Human Behaviour, reveals a significant association between 74 early-life diseases and the likelihood of remaining childless throughout one's life, with 33 of these diseases prevalent in both women and men.

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