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The awardees for the second round of the University of Oxford’s Enriching Engagement funding scheme have now been announced, including six projects from across the Medical Sciences Division.

Trophy of three golden starts linked together

The discovery of robust septin binders to validate their potential as a future drug target

Develop synthetic extracellular matrix for engineering defined 3D human neural tissue

Improving TMS-EEG acquisition for clinical populations

Rapid MRI scanning for population-level neuroimaging

An exploration of the Heart - Liver axis: using MRI to understand how and why measurements taken in the liver relate to adverse cardiovascular outcomes

Exploring the TMEM206 proton-gated chloride channel as a new therapeutic target in ischaemic-mediated capillary disfunction

Design, synthesis and optimisation of antisense oligonucleotide therapeutics for improved cellular uptake and efficacy

Strategies for novel cardiomyopathy treatments from organoids-informed computational multiscale modelling and simulation

Optimising digitally augmented psychological therapies for children and young people through analysis of routinely captured data

Linking physio-chemical properties of adjuvants to immunological responses for the rational design of next generation vaccines

Computational statistics and deep learning to strengthen families and reduce violence towards children

Molecular reclassification of the spectrum of Alzheimer’s disease: Multi-omic, multi-modal models for diagnosis, risk stratification and prognosis prediction

Defining MR1-ligand expression in human and mouse tissues

Neuropeptide regulation of gastric motility as a comorbidity and diagnostic for endometriosis and pancreatic cancer

The mechanisms of control of the TMEM16A channel by the lysosomal NPC1 protein: a new role for the lysosome in the control of cell excitability

Advancing diagnostics for precision medicine in severe infection

Immunogenic response to anti-TNF therapeutics: defining the role of protein glycosylation

Combating memory decline during sleep

Developing a Comprehensive Framework for Clinical Validation of Generative AI in Primary Care: Beyond Performance Metrics

Hunting for injured nerves: Discovering diagnostic and therapeutic biomarkers for painful nerve injury using targeted binding domain libraries from the shark immune system

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